Severe radiation retinopathy and optic neuropathy after brachytherapy for choroidal melanoma, treated by hyperbaric oxygen

Gall, N.; Leiba, Hana; Handzel, Ruth; Pe’er, Jacob

doi:10.1038/sj.eye.6702820

Cited by 22 publications

(11 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a case of 106 Ru-induced radiation retinopathy and optic neuropathy, the patient was treated with hyperbaric oxygen treatment (20 sessions, 2 h each of 100% O 2 at 2 atms) [33]. Hyperbaric oxygen treatment theoretically counteracts the ischemia of radiation retinopathy and neuropathy by improving oxygenation.…”

Section: Other Case Studiesmentioning

confidence: 99%

Treatment of radiation retinopathy following plaque brachytherapy for choroidal melanoma

Wen

McCannel

2009

Current Opinion in Ophthalmology

View full text Add to dashboard Cite

show abstract

Section: Other Case Studiesmentioning

confidence: 99%

Treatment of radiation retinopathy following plaque brachytherapy for choroidal melanoma

Wen

McCannel

2009

Current Opinion in Ophthalmology

View full text Add to dashboard Cite

show abstract

“…In a case report on a patient with post-plaque radiation retinopathy and optic neuropathy, hyperbaric oxygen treatment was given (20 sessions over an unspecified period of time, 2 h each, 100% oxygen at 2 atm), and at 2 months follow-up, the patient's visual field studies showed marked improvement. 44 However, the results of most studies of hyperbaric oxygen treatment in the setting of external beam related optic neuropathy have been poor. 52 A recent review on the efficacy of hyperbaric oxygen treatment found that only a few cases of radiation optic neuropathy had improved with treatment.…”

Section: Treatment Of Radiation-induced Optic Neuropathymentioning

confidence: 99%

Ocular complications following I-125 brachytherapy for choroidal melanoma

Wen

Oliver

McCannel

2009

Eye

View full text Add to dashboard Cite

Uveal melanoma has traditionally been treated with enucleation, plaque brachytherapy, or external beam radiation. Following the results of the multicenter Collaborative Ocular Melanoma Study (COMS), which established no significant difference in mortality rates between enucleation and brachytherapy, plaque brachytherapy has become the favoured modality given its potential for preservation of vision and the eye. Among the radioisotopes that have been used, iodine-125 (I-125) has become the increasingly popular choice in the United States. However, I-125 brachytherapy is associated with complications, including keratitis, iris neovascularization, neovascular glaucoma, radiation retinopathy, and optic neuropathy. The purpose of this review is to discuss the pathogenesis, clinical presentation, and management of complications related to I-125 plaque brachytherapy for choroidal melanoma.

show abstract

“…Unfortunately no proven therapy exists for radiation retinopathy. The use of hyperbaric oxygen is controversial and may even exacerbate retinopathy (49). Intravitreal triamcinolone therapy and laser photocoagulation may briefly decrease macular edema and achieve modest visual improvements (50).…”

Section: Prevention and Treatment Of Toxicitymentioning

confidence: 99%