Severe refractory atopic dermatitis in adults is highly atopic

The relevance of microbial allergens to the IgE antibody repertoire in atopic and nonatopic eczema

“…Moreover, a link between severe refractory AD and atopy has recently been reported. 26 In our study the severity of disease was increased in patients with AD with high IgE levels, and in contrast to patients with low IgE levels, disease severity correlated with total IgE titers. Such observations support the view that allergenic triggers contribute to the development or persistence of severe disease.…”

The role of indoor allergens in chronic allergic disease

“…The etiologic factors include food allergens, contact sensitivity to ointments, skin infection with both bacteria and yeasts, and inhalant allergens. 45,46 The letter from Salt et al 46 in this issue of the Journal strongly reinforces the idea that allergen sensitization is almost universal in the severe forms of the disease. Interestingly, there are striking differences in the circulating T cells in patients with AD that relate to their cell surface markers, their regulatory activity, and their in vitro responses to allergens.…”

Use of Emollients in Atopic Dermatitis: A Questionnaire Survey Study

“…Others continue to have severe disease as adults6. In this study, the severity of AD differed significantly between older and younger patients, with higher EASI scores in older patients (>8 years old) ( p =0.015).…”