Severe respiratory failure due to diffuse alveolar hemorrhage: Clinical characteristics and outcome of intensive care

Diffuse Alveolar Hemorrhage in Acute Myeloid Leukemia

“…4 However, bleeding from other sites may support clinical suspicion for DAH. 5 Our patients exhibited epistaxis, but other signs or symptoms of coagulopathy such as purpura may be present. Acute respiratory failure with hypoxia and an increasing oxygen requirement is also often seen as a presenting symptom.…”

“…Diffuse leukemic infiltration of the lungs may be a manifestation of malignancy and can be confused with DAH. 5 Viral pneumonias, Pneumocystis jiroveci infection, Mycoplasma pneumoniae infection, and toxoplasmosis, among other atypical infections, can often present with diffuse pulmonary infiltrates comparable with CT findings for DAH. 2 Table 2 lists the infectious causes of DAH.…”

Alveolar hemorrhage observed in a case of amphetamine intoxication

“…The pulmonary capillaritis is the most common histology of alveolar hemorrhage 7) . Although alveolar hemorrhages are often associated with various systemic disorders, infectious or toxic exposures may also associate with this condition.…”

“…The most common d r u g s t h a t c a n c a u s e a l ve o l a r h e m o r r h a g e a r e antiplatelets, anticoagulants (ex. heparin) or thrombolytic agents 6), 7) .…”

Non-Infectious Early Complications of Allogeneic Stem Cell Transplantations

“…While infections, cardiac causes including heart failure, toxicity from pre-transplant thoracic radiation, chemotherapy and early marrow engraftment are the factors leading to DAH, no definite cause could be detected in 20% of patients. 63,64 Although the etiology of DAH is still unclear, it is believed that GVHD, inflammatory cytokine release and lung tissue injury may play roles in the pathogenesis of DAH. 65 Gupta S et al has mentioned four criteria in their study for diagnosis of DAH 63 :…”