Severe scleritis and urticarial lesions

Mycophenolate mofetil in dermatology

“…67 Successful treatment of skin lesions in hypocomplementaemic urticarial vasculitis, ChurgeStrauss syndrome, microscopic polyangitis, and Wegner granulomatosis are all reported with overall good tolerability and successful response rates. [68][69][70][71][72][73][74] In light of the latter three named vasculitides, it is not surprising that interest has developed regarding the use of MMF for antineutrophil cytoplasm antibodiese associated vasculitides with the proposal that MMF may actually aid in the removal of these pathogenic antibodies. 69 Although effective in several vasculitides, an attempt at treating Behçet disease has proven nonbeneficial.…”

Urticarial lesions: If not urticaria, what else? The differential diagnosis of urticaria

“…8,102-105 Ocular involvement is severe, but infrequent, with conjunctivitis, recurrent uveitis, scleritis, or optic disc and retinal vasculitis occurring almost exclusively in patients with HUV. 5,9,[106][107][108] Therefore, UV associated with systemic involvement is more likely to be hypocomplementemic, but lower than normal levels of complement may not result following a single determination, and may require multiple testings. Patients with UV and mild or no systemic symptoms but hypocomplementemia need a careful follow-up.…”

Scleritis and Peripheral Ulcerative Keratitis

“…The most commonly associated rheumatic diseases are RA (18-33%); systemic vasculitis (7-19%), of which Wegener's granulomatosis is the most common; systemic lupus erythematosus (SLE)(4-7%); inflammatory bowel disease (4-7%), and relapsing polychondritis (3%) [3,17]. Less commonly associated conditions include sarcoidosis [19,20], cryoglobulinemia [21], and hypocomplementemic urticarial vasculitis [22]. The most commonly associated infection is herpes zoster [18].…”