Severe sepsis bundles

Abstract

Sepsis is a complex syndrome with its wide spectrum of severity, and is one of the most common causes of death in Critical Care Units. The Surviving Sepsis campaign launched in 2004, is aimed at improving diagnosis, management and survival of patients with sepsis. Care bundles are a group of best evidence based interventions which when instituted together, gives maximum outcome benefit. Care Bundles are simple, uniform and have universal practical applicability. Surviving Sepsis campaign guidelines in 2008 incorporated two sepsis care bundles. The Resuscitation bundle includes seven key interventions to be achieved in 6-h while four interventions have to be completed within 24-h in the Management bundle. Compliance with a bundle implies achieving all the specified goals in that bundle. Limitations to care bundles include the quality of the evidence on which they are based, and that the relative contributions of each element of the bundle are not known. Several observational studies support the hypothesis that sepsis care bundles have an important role in improving outcomes from sepsis. Critical Care Units should develop management strategies to ensure compliance with the sepsis bundles in order to decrease hospital mortality due to severe sepsis.

Sepsis: The evolution in definition, pathophysiology, and management

“…Bundles are the group of treatments that are built around the best evidence, and they have known to produce greater benefit when implemented together than as individual therapies. 41 Surviving Sepsis Campaign guidelines in 2008 incorporated sepsis resuscitation bundle to be achieved in 6 h and sepsis management bundle to be achieved in 24 h. In 2012, the 6-h resuscitation bundle was modified into two bundles: “the severe sepsis 3-hour resuscitation bundle” and “the 6-hour septic shock bundle,” which contain all therapeutic goals to be completed, respectively, within 3 and 6 h of presentation with septic shock. 42 In 2018, the 3- and 6-h bundles have been combined into a single 1-h bundle.…”

Easy Protocol Assessment in Children Emergency Room, Irrua Specialist Teaching Hospital Nigeria

“…[10] Due to the global burden and high mortality arising from sepsis, consistent efforts have been made to develop sepsis care bundles aimed at reducing the mortality rates of sepsis. Care bundles are a group of simple and practical interventions which when administered together on the septic patient, yields maximum outcome benefit [11] In 2004, the surviving sepsis campaign (SSC) was launched aiming to improve the survival of patients with sepsis and in 2008, SSC guidelines incorporated two sepsis care bundles. [12] Further revisions of SSC guidelines have been done over the years and other sepsis bundles have also been launched in several settings globally including "sepsis six" in the UK.…”