Severe Skin Lesions or Arthritis May be Associated with Coronary Artery Lesions in Kawasaki Disease

Youn, Song Ee; Ju, Hee Young; Lee, Kyung Suk; Ho, Sung; Han, Mi Young; Yoon, Kyung Lim

doi:10.14776/piv.2016.23.2.102

Cited by 1 publication

(8 citation statements)

References 23 publications

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“…Sixteen studies were retrospective [ 13 – 23 , 25 – 29 ], and one study was prospective [ 24 ]. Twelve studies were written in English [ 13 – 17 , 19 – 25 ], one in Turkish [ 18 ], and two studies in Chinese [ 26 , 29 ]. Sixteen studies were published as journal articles [ 13 – 21 , 23 – 29 ] and one study as a preprint [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

“…All the selected studies were published from 2015 to 2021. Of 17 articles, seven came from China [21,22,24,[26][27][28][29], four from Korea [16,19,20,25], three from Turkey [13,17,18], one from Japan [23], one from Taiwan [14], and one from Thailand [15]. Sixteen studies were retrospective [13][14][15][16][17][18][19][20][21][22][23][25][26][27][28][29], and one study was prospective [24].…”

Section: Characteristics Of Includedmentioning

confidence: 99%

“…Of 17 articles, seven came from China [21,22,24,[26][27][28][29], four from Korea [16,19,20,25], three from Turkey [13,17,18], one from Japan [23], one from Taiwan [14], and one from Thailand [15]. Sixteen studies were retrospective [13][14][15][16][17][18][19][20][21][22][23][25][26][27][28][29], and one study was prospective [24]. Twelve studies were written in English [13][14][15][16][17][19][20][21][22][23][24][25], one in Turkish [18], and two studies in Chinese [26,29].…”

Section: Characteristics Of Includedmentioning

confidence: 99%

“…There is growing evidence that both innate and adaptive immune cells mediate the systemic and tissue-specific effects of KD-like CA aneurysms [9]. In light of this, several studies have suggested that NLR calculation may aid in the clinical assessment of the inflammatory aspect of KD, serving as a metric for risk stratification and prediction for adverse cardiac events in adulthood [13][14][15][16][17][18][19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

“…Finally, 17 articles with 6334 KD patients, of whom 1328 developed CAA, were enrolled in this meta-analysis [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. The list of included studies is shown in supplementary file B.…”

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confidence: 99%

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Neutrophil to Lymphocyte Ratio as a Biomarker for Predicting the Coronary Artery Abnormality in Kawasaki Disease: A Meta-Analysis

et al. 2022

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We conducted a systematic review and meta-analysis on the relationship between the neutrophil to lymphocyte ratio (NLR) and coronary artery abnormalities (CAA) in patients with Kawasaki disease (KD), according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statements. We searched PubMed, Scopus, Web of Science, Embase, TRIP, Google Scholar, and ProQuest up to the 8th of August 2022. This was done to retrieve eligible studies. No date or language limitations were considered in this study. Methodology quality assessment was conducted according to the Newcastle–Ottawa scale (NOS). Standard mean difference (SMD) and its 95% confidence interval (CI) were used to depict the pooled continuous variables. Finally, 17 articles with 6334 KD patients, of whom 1328 developed CAA, were enrolled in this meta-analysis. NLR level was significantly higher in KD patients with CAA compared to those without CAA (SMD =0.81; 95% CI =0.05–1.57, P = 0.03 ). In addition, NLR level was significantly higher in patients with coronary artery aneurysms than those without coronary artery aneurysms (SMD =2.29; 95% CI =0.18–4.41, P = 0.03 ). However, no significant association between NLR and coronary artery dilation was observed in this meta-analysis (SMD =0.56; 95% CI = -0.86–1.99). There was no publication bias for the pooled SMD of NLR for coronary artery abnormality in KD (Egger’s test P = 0.82 ; Begg’s test P = 0.32 ). The NLR may be useful in monitoring CAA development in these patients and may further imply a mechanistic role in potential inflammation that mediates this process.

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