Severe strongyloidiasis complicated by meningitis and hydrocephalus in an HTLV-1 carrier with increased proviral load

Satoh, Masao; Futami, Atsushi; Takahira, Kenichiro; Kodaira, Makoto; Tanaka, Tokutaro; Kuriki, Ken; Hori, Eitaro

doi:10.1007/s10156-003-0272-4

Cited by 13 publications

(7 citation statements)

References 13 publications

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“…These are all factors that have been shown to be critical in the immune control of S. stercoralis, 3,6,7,17 -23 while CD4 + lymphocyte count usually remains within normal limits. 7 The globally down-regulated activation of type 1 immune cells prompted by the concomitant HTLV-1 infection leads to a much more frequent atypical presentation and course of strongyloidiasis (like meningeal, genital, respiratory, intra-abdominal, or muscle localizations), 6,7,19,22 with rare but possible lethal outcome. 6 As a consequence, clinicians should remember that a relapsing strongyloidiasis may herald a missed, concurrent HTLV-1 infection, 7 and the association of strongyloidiasis with HTLV-1 infection may result in a remarkable increase of disseminated or recurring forms of this helminthiasis, also due to a reduced therapeutic response, 3,17 -19 so that a careful and probably lifetime monitoring is recommended for these coinfected patient.…”

Section: Discussionmentioning

confidence: 99%

Management of Strongyloides stercoralis Extensive Infestation in a Patient With Sjögren Syndrome

Sabbatani¹,

Manfredi²,

Baccarini³

et al. 2006

Infectious Diseases in Clinical Practice

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A rare case report of serious, relapsing, and difficult-totreat Strongyloides stercoralis enteric infestation that occurred in a patient affected by the autoimmune Sjögren disease (a pathologic association never reported before), chronically treated with corticosteroids, has been presented and evaluated on the ground of the available literature evidences in this field. In particular, the role of underlying (and iatrogenic) immunodeficiency in the pathogenesis of S. stercoralis persisting infection and the unresolved diagnostic and therapeutic issues in the setting of strongyloidiasis are discussed. Particular attention is focused on the need to maintain clinical suspicion for this nematode worm infestation in patients suffering from a large spectrum of collagen vascular diseases, and the need for randomized clinical trials to determine suitable firstline and subsequent lines of treatment, especially when immunodeficiency and a relapsing Strongyloides disease are suspected. (Infect Dis Clin Pract 2006;14:380-384)

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Section: Discussionmentioning

confidence: 99%

Management of Strongyloides stercoralis Extensive Infestation in a Patient With Sjögren Syndrome

Sabbatani¹,

Manfredi²,

Baccarini³

et al. 2006

Infectious Diseases in Clinical Practice

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“…Risk groups for acquiring the infection include residents and travelers to Southern, Eastern and Central Europe, Latin America, sub-Saharan Africa, and the Caribbean islands. [3,[5][6][7][8] Our patient was not from these regions and had not traveled outside the East Anatolian region of Turkey.…”

Section: Case Reportmentioning

confidence: 99%

“…Iatrogenic or disease-related immune deficiency causes hyperinfection and disseminated strongyloidiasis. [2][3][4][5][6]8] It is reported that gastrointestinal involvement is commonly seen in patients with immunodeficiency, but Thompson et al [7] reported two cases that were immunocompetent. [1,7,9] We investigated the immunological status of our patient, after the pathologic examination revealed S. stercoralis, and found that she was not immunocompromised.…”

Section: Case Reportmentioning

confidence: 99%

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Gastric perforation caused by Strongyloides stercoralis: a case report

Öztürk

Aydınlı²,

Çelebi³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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Stronglodiasis, Strongyloides stercoralis'in dişi nematodları tarafından oluşturulan bir parazitozdur. S. stercoralis olguların %50'sinde asemptomatik olan ve mideyi etkileyebilen kronik bir enfeksiyon oluşturur. Mide tutulumu genelde gastriti taklit eden bulgulara neden olur. Biz burada 37 yaşındaki kadın hastada S. stercoralis'e bağlı oluş-tuğunu düşündüğümüz bir mide delinmesi olgusunu sunuyoruz.Anahtar Sözcükler: Strongyloides stercoralis; mide tutulumu; delinme.Strongyloidiasis is a parasitosis caused by the female nematode of the Strongyloides stercoralis. S. stercoralis causes a chronic infection that is asymptomatic in 50% of chronically infected patients, and it can also affect the stomach. Gastric involvement causes symptoms mostly mimicking gastritis. We report herein a case of gastric perforation in a 37-year-old woman, which was thought to be caused by S. stercoralis.

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“…The strongyloidiasis hyperinfection syndrome is characterized by disseminated infection and an association with enteric bacteremia and meningitis [12,[17][18][19]. Strongyloidiasis hyperinfection syndrome has been classically described in association with corticosteroid therapy but is also associated with other immunosuppressive agents, organ transplantation, hematological malignancies, malnutrition, and HTLV-1 infection [20].…”

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confidence: 99%