Severe Symptomatic Hypocalcemia, complicating cardiac arrhythmia following Cinacalcet (Sensipar^TM) administration: A Case Report

Abstract

Clinicians should closely monitor patients on calcimimetics for hypocalcemic symptoms and arrhythmia, even though asymptomatic hypocalcemia typically resolves without intervention.

Small vs. Large Library Docking for Positive Allosteric Modulators of the Calcium Sensing Receptor

“…In this sense, the experimental structures provide an additional layer of information in terms of global conformations that may help explain differences in the relative efficacy and pharmacology of different ligands. Correspondingly, '54149 promotes a TM6-TM6 interface that is closest to the fully active G-protein coupled state of the receptor dimer and is highly potent in suppressing PTH secretion, while also seemingly devoid of the hypocalcemia that is the key dose-limiting side effect of approved calcimimetic drugs 44,45 Several caveats merit mentioning. We do not pretend the molecules described here are drugs, or even drug candidates.…”