Severe thrombosis during oestrogen treatment for tall stature

Abstract

This case report illustrates that the risk of thromboembolism in the treatment of tall girls with high dose oestrogens is not negligible.

Outcome in tall stature. Final height and psychological aspects in 220 patients with and without treatment

“…An increased risk of thrombophilia under high-dose oestrogen treatment has been discussed, and sporadically deep thrombosis associated with this therapy was reported [4,21]. Failure of reproductive function or association with malignancies as long-term side-eects in women have not been reported but adequate data are missing.…”

Sex Steroid Treatment of Constitutionally Tall Stature*

“…In most studies, unwanted side effects have been reported only during treatment or shortly after discontinuation of therapy (109,112,113,127,128,130,131,183,189,196,197). Most side effects were found to be mild and reversible (see Table 9).…”

“…This would suggest a dose-dependent effect of estrogens on the incidence of adverse events (107,130). Although hemostatic changes have been reported (196,200,201), thrombosis is found to be a very uncommon side effect of height-reductive therapy (112,132,196). Whenever thrombosis occurred it usually coincided with other risk factors for thromboembolism such as immobilization (202).…”

Severe Thrombosis during Treatment with Ethinylestradiol for Tall Stature

“…Estro gen treatment is offered for that reason with good toler ance [6], Well-known common side effects during therapy are nausea, edema, weight gain, headache, vomiting and hypermenorrhea [2, 6. 7], Until now there has been only one report about severe deep venous thrombosis during estrogen treatment for tall stature that happened during a short period of immobilisation [8]. We present an addi Clinical Report A 14.6-year-old postmenarcheal girl, a nonsmoker of normal weight, presented with an actual height of 182.5 cm.…”