Severinia buxifolia-isolated acridones inhibit lung cancer invasion and decrease HIFα protein synthesis involving 5’UTR-mediated translation inhibition

Chen, Pin-Wei; Huang, Shiang Suo; Chou, Wen‐Cheng; Chang, Fang-Rong; Cheng, Yuan-Bin; Wang, Hui‐Chun

doi:10.1016/j.phymed.2022.154570

Cited by 3 publications

(2 citation statements)

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“…Lung cancer is the most common malignant tumor worldwide and has the highest mortality rate. LUAD accounts for about 40% of lung cancer ( 1 , 3 , 4 ). Currently, the annual mortality rate of LUAD patients remains high.…”

Section: Discussionmentioning

confidence: 99%

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A new prognostic model for RHOV, ABCC2, and CYP4B1 to predict the prognosis and association with immune infiltration of lung adenocarcinoma

Li¹,

Liu²,

Ni³

et al. 2023

J Thorac Dis

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Background: Lymph node metastasis is one of the important factors affecting the prognosis of lung adenocarcinoma (LUAD) patients. The key molecules in lymph node metastasis have not yet been fully revealed. Therefore, we aimed to construct a prognostic model based on lymph node metastasis-related genes to evaluate the prognosis of LUAD patients. Methods:The differentially expressed genes (DEGs) in the process of LUAD metastasis were identified in The Cancer Genome Atlas (TCGA) database, and the biological roles of the DEGs were depicted using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and a protein-protein interaction (PPI) network. Survival analysis and Cox regression analysis were used to identify the genes related to the prognosis of patients with LUAD, and a nomogram and a prognostic model were constructed.The potential prognostic value, immune escape, and regulatory mechanisms of the prognostic model in LUAD progression were explored through survival analysis and gene set enrichment analysis (GSEA).Results: A total of 75 genes were upregulated, and 138 genes were downregulated in tissues of lymph node metastasis. The expression levels of STC1,

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Section: Discussionmentioning

confidence: 99%

“…Lung cancer is one of the most common malignant tumors worldwide, as well as one of the main causes of cancer-related death ( 1 , 2 ). In China, the morbidity and mortality of lung cancer remain high throughout the entire year ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

A new prognostic model for RHOV, ABCC2, and CYP4B1 to predict the prognosis and association with immune infiltration of lung adenocarcinoma

Li¹,

Liu²,

Ni³

et al. 2023

J Thorac Dis

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Conchocarpus J. C. Mikan (Rutaceae): Chemical Constituents and Biological Activities

Santos,

de Paula,

Barbosa

2024

Chemistry & Biodiversity

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Rutaceae Juss. stands out as a botanical family recognized for its remarkable diversity in taxonomy, worldwide distribution, chemical composition, and biological activity exhibited by its compounds. Conchocarpus J. C. Mikan is one of the main genera of this family, comprising 50 species distributed throughout the Neotropical America. Brazil is the main center of diversity for this genus, hosting 72% of the species as endemic. This is the first review concerning the genus Conchocarpus, emphasizing its chemical composition and biological activities. The selected papers for this review cover studies on 11 species, of which were identified 88 compounds. Among these, quinoline and acridone alkaloids predominate (57%), followed by flavonoids, amides, coumarins and terpenoids. The biological activities of extracts and compounds indicate trypanocidal and leishmanicidal actions, as well as cytotoxic, fungicidal, molluscicidal, insecticidal, anticholinesterase and antioxidant activities.

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Exploring hypoxia-induced ncRNAs as biomarkers and therapeutic targets in lung cancer

Thangavelu,

Imran,

Alsharari

et al. 2024

Pathology - Research and Practice

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Severinia buxifolia-isolated acridones inhibit lung cancer invasion and decrease HIFα protein synthesis involving 5’UTR-mediated translation inhibition

Cited by 3 publications

References 57 publications

A new prognostic model for RHOV, ABCC2, and CYP4B1 to predict the prognosis and association with immune infiltration of lung adenocarcinoma

A new prognostic model for RHOV, ABCC2, and CYP4B1 to predict the prognosis and association with immune infiltration of lung adenocarcinoma

Conchocarpus J. C. Mikan (Rutaceae): Chemical Constituents and Biological Activities

Exploring hypoxia-induced ncRNAs as biomarkers and therapeutic targets in lung cancer

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