Severity of abruptio placentae and neurodevelopmental outcome in low birth weight infants

Spinillo, Arsenio; Fazzi, Elisa; Stronati, Mauro; Ometto, Ana María Holland; Iasci, Angela; Guaschino, Secondo

doi:10.1016/0378-3782(93)90138-k

Cited by 49 publications

(36 citation statements)

References 11 publications

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“…The decreased risk of cerebral palsy among very preterm infants born to preeclamptic mothers [Murphy et al, 1995;Allan et al, 1997;O'Shea et al, 1998b;Spinillo et al, 1998;] could be explained by the lower frequency of intrauterine infection in women with severe preeclampsia or by the higher blood pressure that their infants have, on average [Collins and Paneth, 1998]. The increased risk of cerebral palsy among infants born to mothers with placental abruption [Spinillo et al, 1993], could be due either to an impairment of placental function, resulting in fetal hypoxemia, bradycardia, and hypotension, or to the previously described association of placental abruption and chorioamnionitis. The apparent effect of sepsis could be attributable to either a direct effect of inflammatory cytokines or to disseminated intravascular coagulation, with occlusion of cerebral blood vessels by small blood clots.…”

Section: Epidemiologic Data Support the Possibilities Of Ischemia-andmentioning

confidence: 97%

Cerebral palsy in very preterm infants: new epidemiological insights

O’Shea

2002

Ment. Retard. Dev. Disabil. Res. Rev.

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The focus of this review is on new insights from recent epidemiological research on cerebral palsy in preterm infants. These include: 1) a better understanding of issues related to diagnosis and classification; 2) new information about the brain abnormalities underlying cerebral palsy in preterm infants; and 3) a better understanding of biological mechanisms that may underlie previously described epidemiological associations. Ongoing efforts to improve the diagnosis and classification of cerebral palsy have been enhanced by findings from serial examinations of cohorts of very preterm infants. Cranial ultrasonography through the anterior fontanelle of very preterm infants has provided information about grossly evident brain damage, found in about one-half of preterm infants who develop cerebral palsy. Insights into the pathophysiologic basis for certain epidemiologic associations have come from studies of experimental brain damage in animals and clinical studies of neurologic disorders in adults. Much of the current epidemiological research into the causes of cerebral palsy in preterm infants has focused on two potential mechanisms of brain damage. One mechanism involves insufficient cerebral perfusion; the other, cytokine-mediated damage, potentially triggered by events such as maternal infection (e.g., intrauterine or periodontal infection), neonatal infection (e.g., sepsis and necrotizing enterocolitis), and neonatal oxygen- or ventilator-induced lung injury. In addition to the preterm infant's increased exposure to such damaging factors, the high frequency of cerebral palsy in these infants might be due, in part, to insufficient levels of developmentally regulated protective substances, such as thyroid hormone and glucocorticoids. Models of causation currently are being investigated using recently developed methods for quantifying, with small quantities of blood, biomolecules that are suspected to either promote or protect against brain damage in the neonate. Clinical investigations now under way can be expected to identify strategies to be tested in clinical trials that could lower the risk of cerebral palsy in very preterm infants.

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Section: Epidemiologic Data Support the Possibilities Of Ischemia-andmentioning

confidence: 97%

Cerebral palsy in very preterm infants: new epidemiological insights

O’Shea

2002

Ment. Retard. Dev. Disabil. Res. Rev.

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“…Chances of development of cystic periventricular leucomalacia or intraventricular haemorrhage are higher in neonates born after severe placental abruption. 16,17 The risk increases with prematurity and low birth weight. Severe placental abruption increases the risk for cerebral palsy and it is also linked with sudden infant death syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…According to Spinillo et al, there is a greater risk for long term abnormal neurobehavioral outcomes in infants born after placental abruption. 21 In abruptio placenta, the incidence of abnormal foetal heart tracings and emergency caesarean section are high. When caesarean is required in the case of placental abruption with foetal bradycardia, a decision to incision interval of less than 20 minutes shows a better foetal outcome compared to 30-minute interval.…”

Section: Discussionmentioning

confidence: 99%

Foetal Outcome Among Abruptio Placentae Cases at a Tertiary Hospital in Kerala, India- A Retrospective Analysis

Koshy¹,

Alexander²

2018

jebmh

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BACKGROUNDAbruptio placentae denotes separation of a normally implanted placenta after 20 weeks of gestation. This is a uniquely dangerous condition to both the mother and the foetus because of its potentially serious pathologic sequelae. Abruptio placentae may lead to antagonistic foetal outcomes such as low birth weight, preterm birth, intrauterine growth restriction, birth asphyxia, foetal distress, low Apgar score, transfer to neonatal intensive care unit, stillbirth, congenital anomalies and perinatal death.The objective of this study is to examine the foetal outcomes in abruptio placentae cases in a tertiary care center in Kerala.

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“…Facteurs maternels Retard mental, épilepsie, dysthyroïdie, diabète insulino-dépendant, oligospanio-ménorrhée, intervalles longs entre les grossesses, tabagisme [7,11,12] Primiparité et âge supérieur à 35 ans [7] Thrombophilies [13,14] Complications de la grossesse Prématurité [15] Infections virales [16] Chorio-amniotite [17,18] Pré-éclampsie [12,19] Hémorragies antepartum : placenta praevia [11], hématome rétroplacentaire [11,12,20] Grossesses multiples [15,21] …”

Section: Principaux Facteurs De Risque Des Imoc Dans Les éTudes éPidéunclassified

“…1), des maladies génétiques, des maladies métaboliques, des encéphalopathies en relation avec hypoglycémie sévère ou une hyperbilirubinémie, ou encore par des atteintes toxiques, alcool, tabac ou cocaïne notamment [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

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Asphyxie périnatale et infirmité motrice d’origine cérébrale (I- Le diagnostic)

Boog

2010

Gynécologie Obstétrique & Fertilité

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Severity of abruptio placentae and neurodevelopmental outcome in low birth weight infants

Cited by 49 publications

References 11 publications

Cerebral palsy in very preterm infants: new epidemiological insights

Cerebral palsy in very preterm infants: new epidemiological insights

Foetal Outcome Among Abruptio Placentae Cases at a Tertiary Hospital in Kerala, India- A Retrospective Analysis

Asphyxie périnatale et infirmité motrice d’origine cérébrale (I- Le diagnostic)

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