Severity of atopic dermatitis in relation to food and inhalant allergy in adults and adolescents

Abstract

The aim of this study is the evaluation of the relationship between the severity of atopic dermatitis (AD) and the occurrence of IgEmediated food allergy, food sensitization, and sensitization to inhalant allergens. The complete dermatological and allergological examinations were performed and the severity of AD was evaluated with the SCORing Atopic Dermatitis index. The statistical evaluation of the relationship between the occurrence of IgE-mediated food allergy, food sensitization, sensitization to inhalant allergens, and the severity of AD was performed. Two hundred and eighty-three patients were examined, 89 men and 194 women, average age 26.2 (s.d. 9.5). The significant relation was recorded between the severity of AD and sensitization to tested inhalant allergens. The significant relation was also found between the severity of AD and IgE-mediated food allergy. It turns out that the higher time to reaction, the higher the severity of AD.

Atopic dermatitis in adolescents and adults – the evaluation of association with other allergic diseases and parameters

“…Patients suffering from moderate and severe forms of AD suffer significantly more often from sensitization to mites, animal dander, dust and feather in comparison to patients with mild form of AD (Celakovska & Bukac, 2017b), (Table 1 the rising occurrence of sensitization to inhalant allergens). A significant relation was also found between the severity of AD and the occurrence of early, combined and late IgE-mediated food allergy reaction.…”

“…The occurrence of food sensitization to cow's milk, wheat, egg white and yolk, soy and peanuts is not in significant relation to the severity of AD (patients with positive results of sIgE and/or SPT and/or APT without the clinical symptoms) (Celakovska & Bukac, 2017b), (Table 2). Regarding the relation between the food hypersensitivity reactions and the severity of AD, we confirmed that patients with AD and food hypersensitivity reactions suffer significantly more often from moderate and severe forms of AD (Celakovska & Bukac, 2015b), ( Table 2).…”

“…Food allergy was examined to cow milk, wheat, egg white and yolk, soy and peanuts. It turns out that the higher the time to food reaction the higher the severity of AD (Celakovska & Bukac, 2017b), ( Table 2).…”

“…We have created a unique group of patients, in which the different parameters concerning atopic march in 172-301 patients were studied. The detailed description of these studies is recorded in our previous publications (Celakovska, Bukac, & Ettler, 2015;Celakovska, Ettlerova, Ettler, Vaněčková, & Bukač, 2015;Celakovska & Bukac, 2015a, 2015b, 2016a, 2016b, 2017a, 2017bČelakovská, Krčmová, Bukač, & Vaněčková, 2017;Vaneckova & Bukac, 2016. All these patients were examined in the Department of Dermatology, Faculty Hospital Hradec Králové, Charles University of Prague, Czech Republic.…”

Is there an association between indoor allergens and the severity of atopic dermatitis?

“…Multiple studies have shown that similarly to other atopic diseases such as asthma and allergic rhinitis, AD patients have increased aeroallergen sensitization . However, scarce literature is available that evaluates the association between exposure to indoor allergens like house dust mite (HDM), pet dander, and fungi, with AD severity . Nowadays, multiparametric methods have been developed that permit the simultaneous detection of multiple allergens in a single dust sample, with high sensitivity and specificity, as well as an excellent interassay reproducibility .…”