Severity of depressive symptoms moderates the sympathoinhibitory effect of local skin warming following exposure to a social stressor

Tyler, Mark P.; Wright, Bradley J.; Beaton, Russell; Monger, Katherine; Raison, Charles L.; Lowry, Christopher A.; Evans, Lynette; Hale, Matthew W.

doi:10.1016/j.psyneuen.2023.106420

Psychoneuroendocrinology

2024

DOI: 10.1016/j.psyneuen.2023.106420

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Severity of depressive symptoms moderates the sympathoinhibitory effect of local skin warming following exposure to a social stressor

Mark P. Tyler,

Bradley J. Wright,

Russell Beaton

et al.

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2024

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Cited by 2 publications

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Heart–Brain Axis: A Narrative Review of the Interaction between Depression and Arrhythmia

Fang,

Zhang

2024

Biomedicines

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Arrhythmias and depression are recognized as diseases of the heart and brain, respectively, and both are major health threats that often co-occur with a bidirectional causal relationship. The autonomic nervous system (ANS) serves as a crucial component of the heart–brain axis (HBA) and the pathway of interoception. Cardiac activity can influence emotional states through ascending interoceptive pathways, while psychological stress can precipitate arrhythmias via the ANS. However, the HBA and interoception frameworks are often considered overly broad, and the precise mechanisms underlying the bidirectional relationship between depression and arrhythmias remain unclear. This narrative review aims to synthesize the existing literature, focusing on the pathological mechanisms of the ANS in depression and arrhythmia while integrating other potential mechanisms to detail heart–brain interactions. In the bidirectional communication between the heart and brain, we emphasize considering various internal factors such as genes, personality traits, stress, the endocrine system, inflammation, 5-hydroxytryptamine, and behavioral factors. Current research employs multidisciplinary knowledge to elucidate heart–brain relationships, and a deeper understanding of these interactions can help optimize clinical treatment strategies. From a broader perspective, this study emphasizes the importance of considering the body as a complex, interconnected system rather than treating organs in isolation. Investigating heart–brain interactions enhance our understanding of disease pathogenesis and advances medical science, ultimately improving human quality of life.

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Heart–Brain Axis: A Narrative Review of the Interaction between Depression and Arrhythmia

Fang,

Zhang

2024

Biomedicines

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The Mediating Role of Interoceptive Sensitivity in the Relationship between Physical Activity and Depression Symptoms in College Students

Sun,

Shen,

et al. 2024

Behavioral Sciences

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A substantial body of evidence indicates that neurological, psychological, and behavioral health issues are profoundly linked to interoceptive sensitivity. The present study aimed to identify the effects of interoceptive sensitivity on the relationship between physical activity and symptoms of depression in Chinese college students. This study employed a cross-sectional design using convenience sampling. An online self-reported survey was distributed to college students in China. The participants’ interoceptive sensitivity, physical activity levels, and depressive symptoms were measured using the MAIA-2, IPAQ-SF, and PHQ-9, respectively. The mediating effect was tested via regression analysis and a parallel mediation model, with bootstrap confidence intervals for indirect effects. The results showed a significant negative correlation between physical activity and depression. A significant positive correlation was observed between physical activity and seven dimensions of interoceptive sensitivity. Conversely, interoceptive sensitivity exhibited a negative correlation with depression. The bootstrap mediation analysis showed that the “not distracting” and “trusting” dimensions of interoceptive sensitivity had significant indirect effects on the relationship between physical activity and depression, suggesting that physical activity might reduce depressive symptoms via these two interoceptive sensitivity dimensions. The findings suggest that interoceptive sensitivity should be integrated into therapeutic interventions, such as physical activity interventions, in the treatment of mental illnesses, particularly depression. Increasing physical activity levels, with a specific focus on enhancing interoceptive modulation, appears to be a promising approach for addressing depression in college students.

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Severity of depressive symptoms moderates the sympathoinhibitory effect of local skin warming following exposure to a social stressor

Cited by 2 publications

References 50 publications

Heart–Brain Axis: A Narrative Review of the Interaction between Depression and Arrhythmia

Heart–Brain Axis: A Narrative Review of the Interaction between Depression and Arrhythmia

The Mediating Role of Interoceptive Sensitivity in the Relationship between Physical Activity and Depression Symptoms in College Students

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