Severity of neurological Long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors

Seibert, Felix S.; Stervbo, Ulrik; Wiemers, Lea; Skrzypczyk, Sarah; Hogeweg, Maximillian; Bertram, Sebastian; Kurek, Julia; Anft, Moritz; Westhoff, Timm H.; Babel, Nina

doi:10.1016/j.autrev.2023.103445

Cited by 16 publications

(4 citation statements)

References 43 publications

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“…Another category of autoantibodies targets G-protein coupled receptors (GPCRs), which have been implicated in cardiovascular and neurological development (345). In long COVID patients, a1 adrenergic receptor (a 1 AdR), b 1 AdR, and b 2 AdR and the muscarinic acetylcholine receptors M 2 (M 2 AChR), M 3 AChR, and M 4 AChR were the most found and correlates with the severity of the neurological symptoms (345)(346)(347).…”

Section: Immune Response During Long Covidmentioning

confidence: 99%

Pathophysiological, immunological, and inflammatory features of long COVID

Bohmwald,

Diethelm-Varela,

Rodríguez-Guilarte

et al. 2024

Front. Immunol.

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The COVID-19 pandemic continues to cause severe global disruption, resulting in significant excess mortality, overwhelming healthcare systems, and imposing substantial social and economic burdens on nations. While most of the attention and therapeutic efforts have concentrated on the acute phase of the disease, a notable proportion of survivors experience persistent symptoms post-infection clearance. This diverse set of symptoms, loosely categorized as long COVID, presents a potential additional public health crisis. It is estimated that 1 in 5 COVID-19 survivors exhibit clinical manifestations consistent with long COVID. Despite this prevalence, the mechanisms and pathophysiology of long COVID remain poorly understood. Alarmingly, evidence suggests that a significant proportion of cases within this clinical condition develop debilitating or disabling symptoms. Hence, urgent priority should be given to further studies on this condition to equip global public health systems for its management. This review provides an overview of available information on this emerging clinical condition, focusing on the affected individuals’ epidemiology, pathophysiological mechanisms, and immunological and inflammatory profiles.

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Section: Immune Response During Long Covidmentioning

confidence: 99%

Pathophysiological, immunological, and inflammatory features of long COVID

Bohmwald,

Diethelm-Varela,

Rodríguez-Guilarte

et al. 2024

Front. Immunol.

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“…Антитела к интерферону Тяжесть COVID-19 [121][122][123] Антитела к хемокинам (СXCL17, CCL18, CCL22) Протективный эффект [186] Антитела к ИЛ-1Ра Нарушение иммунорегуляции [187] Антитела к сурфактанту легких Нарушение функции легких [185] Антинейрональные антитела (ARHGAP31, GAD65, рецепторы ацетилхолина, В1.2б MOG, NMDA, MCTP1, Yo, миелин, Ma/Ta2) Невропсихиатрические проявления COVID-19 [305] Антитела к рецепторам вазорегуляции и вегетативной нервной системы Неврологические нарушения при длительном COVID [306] Антитела к ТФ4-комплексу гепарин -ТФ4 Тяжесть COVID-19 [152], тромботическая тромбоцитопения после вакцинации против SARS-CoV-2 [153] Примечание: NETs -«нейтрофильные внеклеточные ловушки» (neutrophil extracellular traps) Научно-практическая ревматология. 2024;62(1):32-54…”

Section: антинуклеарные антителаunclassified

Coronavirus disease 2019 (COVID-19) pandemic and autoimmune rheumatic diseases: Outcomes and prospects

Nasonov

2024

Naučno-praktičeskaâ revmatologiâ

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The pandemic of coronavirus disease 2019 (COVID-19), etiologically related to the SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus-2), has drawn attention to new clinical and fundamental problems in the immunopathology of human diseases associated with virus-induced autoimmunity and autoinflammation. The provision that “the experience gained in rheumatology in the process of studying the pathogenetic mechanisms and pharmacotherapy of immunoinflammatory rheumatic diseases as the most common and severe forms of autoimmune and autoinflammatory pathology in humans will be in demand for deciphering the nature of the pathological processes underlying COVID-19 and developing approaches to effective pharmacotherapy” was confirmed in numerous studies conducted over the next 3 years in the midst of the COVID-19 pandemic. The main focus will be on a critical analysis of data regarding the role of autoimmune inflammation, which forms the basis of the pathogenesis of immune-mediated rheumatic diseases in the context of the immunopathology of COVID-19.

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“…Such immune effectors can affect cytokine function and endothelial integrity, leading to fatigue and myelitis, and may induce an abnormal renin–angiotensin response, or cause malignant hypertension-related ischemia [ 9 ]. Further, autoantibodies appear to be at much higher levels in long COVID patients, as compared to non-COVID or COVID patients and correlate with the intensity of cognitive and physical impairments [ 10 ]. These examples indicate that long COVID remains a complex and poorly understood condition with a wide range of clinical manifestations.…”

Section: Introductionmentioning

confidence: 99%

Long COVID: Molecular Mechanisms and Detection Techniques

Constantinescu-Bercu,

Lobiuc,

Căliman-Sturdza

et al. 2023

IJMS

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Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), has emerged as a significant health concern following the COVID-19 pandemic. Molecular mechanisms underlying the occurrence and progression of long COVID include viral persistence, immune dysregulation, endothelial dysfunction, and neurological involvement, and highlight the need for further research to develop targeted therapies for this condition. While a clearer picture of the clinical symptomatology is shaping, many molecular mechanisms are yet to be unraveled, given their complexity and high level of interaction with other metabolic pathways. This review summarizes some of the most important symptoms and associated molecular mechanisms that occur in long COVID, as well as the most relevant molecular techniques that can be used in understanding the viral pathogen, its affinity towards the host, and the possible outcomes of host-pathogen interaction.

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Severity of neurological Long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors

Cited by 16 publications

References 43 publications

Pathophysiological, immunological, and inflammatory features of long COVID

Pathophysiological, immunological, and inflammatory features of long COVID

Coronavirus disease 2019 (COVID-19) pandemic and autoimmune rheumatic diseases: Outcomes and prospects

Long COVID: Molecular Mechanisms and Detection Techniques

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