Severity of Periodontitis and Metabolic Syndrome: Is There an Association?

Filho, Isaac Suzart Gomes; Mercês, Magno Conceição das; Passos‐Soares, Johelle de Santana; Cruz, Simone Seixas da; Ladeia, Ana Marice; Trindade, Soraya Castro; Cerqueira, Eneida de Moraes Marcílio; Coelho, Julita Maria Freitas; Monteiro, Fernanda Maria Marques; Barreto, Maurício Lima; Vianna, Maria Isabel Pereira; Costa, Maria da Conceição Nascimento; Seymour, G. J.; Scannapieco, Frank A.

doi:10.1902/jop.2015.150367

Cited by 40 publications

(44 citation statements)

References 32 publications

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“…We reported previously that LPS and palmitate, a major saturated fatty acid (SFA), synergistically stimulated proinflammatory cytokine expression by increasing ceramide production in macrophages . Since LPS plays an important role in the pathogenesis of periodontitis, a bacteria‐initiated and inflammation‐associated disease, and SFA is increased in patients with type 2 diabetes or metabolic syndrome (MetS), the findings from our study suggest that ceramide metabolism may play an important role in the increased prevalence and severity of periodontitis in patients with type 2 diabetes or MetS …”

Section: Introductionmentioning

confidence: 49%

“…MetS is a cluster of cardiovascular risk factors including central obesity, high triglycerides, low HDL, high blood pressure, and increased glucose . Clinical studies in recent years have well documented that, like type 2 diabetes, MetS also exacerbates periodontitis . In our studies to explore the underlying mechanisms involved in type 2 diabetes‐ or MetS‐exacerbated periodontitis, we noticed that one of the common features of dyslipidemia for type 2 diabetes and MetS is the increased saturated fatty acid (SFA) that is accompanied with hypertriglyceridemia .…”

Section: Discussionmentioning

confidence: 88%

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LPS and palmitate synergistically stimulate sphingosine kinase 1 and increase sphingosine 1 phosphate in RAW264.7 macrophages

Jin

et al. 2018

Journal of Leukocyte Biology

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It has been well established that patients with diabetes or metabolic syndrome (MetS) have increased prevalence and severity of periodontitis, an oral infection initiated by bacteria and characterized by tissue inflammation and destruction. To understand the underlying mechanisms, we have shown that saturated fatty acid (SFA), which is increased in patients with type 2 diabetes or MetS, and LPS, an important pathogenic factor for periodontitis, synergistically stimulate expression of proinflammatory cytokines in macrophages by increasing ceramide production. However, the mechanisms by which increased ceramide enhances proinflammatory cytokine expression have not been well understood. Since sphingosine 1 phosphate (S1P) is a metabolite of ceramide and a bioactive lipid, we tested our hypothesis that stimulation of ceramide production by LPS and SFA facilitates S1P production, which contributes to proinflammatory cytokine expression. Results showed that LPS and palmitate, a major SFA, synergistically increased not only ceramide, but also S1P, and stimulated sphingosine kinase (SK) expression and membrane translocation in RAW264.7 macrophages. Results also showed that SK inhibition attenuated the stimulatory effect of LPS and palmitate on IL-6 secretion. Moreover, results showed that S1P enhanced the stimulatory effect of LPS and palmitate on IL-6 secretion. Finally, results showed that targeting S1P receptors using either S1P receptor antagonists or small interfering RNA attenuated IL-6 upregulation by LPS and palmitate. Taken together, this study demonstrated that LPS and palmitate synergistically stimulated S1P production and S1P in turn contributed to the upregulation of proinflammatory cytokine expression in macrophages by LPS and palmitate.

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Section: Introductionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 88%

LPS and palmitate synergistically stimulate sphingosine kinase 1 and increase sphingosine 1 phosphate in RAW264.7 macrophages

Jin

et al. 2018

Journal of Leukocyte Biology

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“…Pesquisas têm destacado o papel da atenção odontológica na melhoria direta das condições de saúde bucal, bem como seu efeito benéfico no controle glicêmico 15,34,35 . Além disso, a perda dos dentes pode prejudicar a adoção de práticas alimentares saudáveis, visto que aumenta o consumo de alimentos inadequados, menos consistentes e de alto valor calórico.…”

Section: Discussionunclassified

“…Na Bahia, em um estudo publicado em 2010, a prevalência foi de 23 a 30% na população geral 13,14 . Em 2015, no município de Feira de Santana, foi determinada uma prevalência de 60,8% a 67,0%, em um grupo de diabéticos 15 . Diante da referida escassez de estudos acerca da SM e/ ou seus componentes, faz-se necessário maior aprofundamento nessa temática.…”

Section: Introductionunclassified

Estilo De Vida E Condição Metabólica De Mulheres Diabéticas E/Ou Hipertensas De Uma Região Urbana

Silva

Santos

Almeida

et al. 2017

Rev. Saúde Col. UEFS

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A presente investigação objetivou relacionar o estilo de vida com a condição metabólica de mulheres atendidas no Centro de Atendimento ao Diabético e Hipertenso na cidade de Feira de Santana/BA. Realizou-se um estudo transversal com 259 mulheres adultas, no qual foi traçado o perfil sociodemográfico, de condição de saúde e estilo de vida das participantes a partir de um formulário e por meio de entrevista. O desfecho foi determinado conforme a presença da Síndrome Metabólica (SM). Foram obtidas frequências simples e relativas. A comparabilidade entre os grupos foi feita com o teste qui-quadrado de Pearson ou Exato de Fisher, com nível de significância de 5%. A SM estava presente em 71,81% das participantes. E a média da idade foi 59 ± 13,1 anos. Mulheres não brancas com renda ≥ 1 salário mínimo apresentaram indicadores mais elevados de SM. O consumo de álcool e fumo, a prática de atividade física e o autocuidado bucal foram considerados baixos e todos os componentes da SM mostraram diferenças significantes entre os grupos, exceto a glicemia de jejum. Observaram frequências altas de SM. No entanto a amostra não teve poder suficiente para detectar a real influência de características de estilo de vida na sua ocorrência.

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“…Insulin resistance and inflammation have been studied as causal mechanisms leading to the association between diabetes and periodontitis, but dyslipidaemia may also play a role. Hyperglycaemia negatively influences the regulation of the host's inflammatory response via the deposition of intrinsic glucose products in the tissues, including the periodontium, and thus stimulates pro-inflammatory cytokines [23].…”

Section: Effects Of Periodontitis On Dmmentioning

confidence: 99%

Periodontal Disease And Its Impact on Health, From Cardiovascular Diseases to Metabolic Syndrome

Deschamps¹,

González²,

Durán³

et al. 2017

IOSR JDMS

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Severity of Periodontitis and Metabolic Syndrome: Is There an Association?

Abstract: The results suggest that periodontitis is associated with MetS, and that MetS prevalence is related to severe periodontitis.

Cited by 40 publications

References 32 publications

LPS and palmitate synergistically stimulate sphingosine kinase 1 and increase sphingosine 1 phosphate in RAW264.7 macrophages

LPS and palmitate synergistically stimulate sphingosine kinase 1 and increase sphingosine 1 phosphate in RAW264.7 macrophages

Estilo De Vida E Condição Metabólica De Mulheres Diabéticas E/Ou Hipertensas De Uma Região Urbana

Periodontal Disease And Its Impact on Health, From Cardiovascular Diseases to Metabolic Syndrome

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