Severity of presentation is associated with time to recovery in spinal epidural lipomatosis

Praver, Moshe; Kennedy, Benjamin C.; Ellis, Jason A.; D’Amico, Randy S.; Mandigo, Christopher E.

doi:10.1016/j.jocn.2015.03.005

Cited by 13 publications

(12 citation statements)

References 47 publications

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“…Our study added another potential factor, SEL, which was previously ignored. Excessive EF in the spinal canal may compress the spinal cord and cause mild or severe neurological symptoms [8, 30, 31]. In the present study, two CK patients and seven TK patients exhibited incomplete paraplegia, and all of these patients met the diagnostic criteria of SEL.…”

Section: Discussionmentioning

confidence: 47%

“…SEL is usually asymptomatic; however, if the adipose tissue compresses the spinal cord as the amount increases, it may cause a progressive neurological deficit [7, 8]. Abul-Kasim et al [6] reported an intriguing finding that epidural lipomatosis is a common comorbidity of Scheuermann disease, which is also known as Scheuermann kyphosis (SK) or juvenile kyphosis, and mainly affects the thoracic or thoracolumbar spine in juveniles [9].…”

Section: Introductionmentioning

confidence: 99%

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Spinal epidural lipomatosis – an easily ignored secondary intraspinal disorder in spinal kyphotic deformities

Zhang

Liu

Zhu

et al. 2017

BMC Musculoskelet Disord

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BackgroundA previous study reported a high prevalence of spinal epidural lipomatosis (SEL) in patients with Scheuermann kyphosis (SK) and suggested that it may play a role in the pathogenesis of this disease. According to our observation, however, SEL occurs in other spinal kyphotic deformities as well. The aim of this study was to test the hypothesis that SEL commonly occurs in patients with different types of kyphotic deformities as a secondary intraspinal disorder.MethodsMR images of 16 patients with congenital kyphosis (CK), 40 patients with SK, 13 patients with tuberculotic kyphosis (TK), and 69 age- and sex-matched controls were retrospectively evaluated. The body mass index (BMI), kyphosis Cobb angle, and sagittal diameters of spinal epidural fat (EF) and the dural sac (DS) in the apical region (EFA, DSA) and non-kyphotic region (EFN, DSN) were measured. The EF ratios at the apical vertebral level (EFRA) and in the non-kyphotic region (EFRN) were calculated as EF / (EF + DS).ResultsEFA and EFRA were significantly higher among patients with CK, SK, and TK than among controls (P < 0.05). Seven CK patients (43.8%), 8 SK patients (20.0%), and 11 TK patients (84.6%) fulfilled the diagnostic criteria for SEL, while only 6.3, 2.5, and 0% of patients in the control groups did (P = 0.019, 0.014, and < 0.001, respectively). Spearman’s correlation analysis showed statistically significant correlations between the kyphosis Cobb angle and the amount of EF in all three patient groups.ConclusionsSEL is a common secondary intraspinal disorder in different types of kyphotic deformities, and surgeons should pay increased attention to this intraspinal anomaly because excessive EF may compress the spinal cord and cause neurological deficits.

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Section: Discussionmentioning

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Spinal epidural lipomatosis – an easily ignored secondary intraspinal disorder in spinal kyphotic deformities

Zhang

Liu

Zhu

et al. 2017

BMC Musculoskelet Disord

View full text Add to dashboard Cite

show abstract

“…In previous case reports, SEL was induced in most patients by steroids, obesity, or idiopathic causes [10], [11].…”

Section: Discussionmentioning

confidence: 87%

“…Thereafter, several reports have attributed the development of SEL to the administration of epidural steroid injections [13], [14]. It has been reported that although the dose of steroid may be prescribed based on the time to onset of neurological symptoms, the mental acuity and neurological deterioration is not related to the rate or degree of recovery [10].…”

Section: Discussionmentioning

confidence: 99%

Epidural lipomatosis with cauda equina syndrome in chronic alcoholic patient: A case report

Kim

Lim

2017

International Journal of Surgery Case Reports

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“…However, some patients receive steroid therapy for chronic conditions and may not tolerate treatment cessation. In absence of exogenous steroid therapy, evaluation for possible endogenous corticosteroid overproduction requires investigation [9]. Following that, surgical intervention should be considered.…”

Section: Discussionmentioning

confidence: 99%

Symptomatic spinal epidural lipomatosis after combined hormonal and steroidal palliative therapy of prostate cancer

Awwad

Adam

Patel

et al. 2018

Spinal Cord Ser Cases

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Severity of presentation is associated with time to recovery in spinal epidural lipomatosis

Cited by 13 publications

References 47 publications

Spinal epidural lipomatosis – an easily ignored secondary intraspinal disorder in spinal kyphotic deformities

Spinal epidural lipomatosis – an easily ignored secondary intraspinal disorder in spinal kyphotic deformities

Epidural lipomatosis with cauda equina syndrome in chronic alcoholic patient: A case report

Symptomatic spinal epidural lipomatosis after combined hormonal and steroidal palliative therapy of prostate cancer

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