Severity of subjective forgetfulness is associated with high dietary intake of copper in Japanese senior women: A cross‐sectional study

Odai, Tamami; Terauchi, Masakazu; Suzuki, Risa; Kato, Kiyoko; Hirose, Asuka; Matsuda, Naoyuki

doi:10.1002/fsn3.1740

Cited by 4 publications

(4 citation statements)

References 65 publications

(75 reference statements)

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“…After CQ treatment, deposition of Cu + in the cell was markedly decreased ( Figure 2 ). In an epidemiological study, high dietary intake of copper in elderly Japanese women was associated with the severity of subjective forgetfulness [ 40 ]. PHF-1, CP13, AT180, and AT270-positive phosphorylated tau decreased, suggesting that phosphorylation of tau was suppressed at Ser394/404, Thr231, Thr181, Thr205, and Ser202.…”

Section: Discussionmentioning

confidence: 99%

Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein

Lin

Zhu

Kanaan

et al. 2021

IJMS

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The neuropathological hallmarks of Alzheimer’s disease (AD) are senile plaques (SPs), which are composed of amyloid β protein (Aβ), and neurofibrillary tangles (NFTs), which consist of highly phosphorylated tau protein. As bio-metal imbalance may be involved in the formation of NFT and SPs, metal regulation may be a direction for AD treatment. Clioquinol (CQ) is a metal-protein attenuating compound with mild chelating effects for Zn2+ and Cu2+, and CQ can not only detach metals from SPs, but also decrease amyloid aggregation in the brain. Previous studies suggested that Cu2+ induces the hyperphosphorylation of tau. However, the effects of CQ on tau were not fully explored. To examine the effects of CQ on tau metabolism, we used a human neuroblastoma cell line, M1C cells, which express wild-type tau protein (4R0N) via tetracycline-off (TetOff) induction. In a morphological study and ATP assay, up to 10 μM CQ had no effect on cell viability; however, 100 μM CQ had cytotoxic effects. CQ decreased accumulation of Cu+ in the M1C cells (39.4% of the control), and both total and phosphorylated tau protein. It also decreased the activity of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) (37.3% and 60.7% levels of the control, respectively), which are tau kinases. Of note, activation of protein phosphatase 2A (PP2A), which is a tau phosphatase, was also observed after CQ treatment. Fractionation experiments demonstrated a reduction of oligomeric tau in the tris insoluble, sarkosyl soluble fraction by CQ treatment. CQ also decreased caspase-cleaved tau, which accelerated the aggregation of tau protein. CQ activated autophagy and proteasome pathways, which are considered important for the degradation of tau protein. Although further studies are needed to elucidate the mechanisms responsible for the effects of CQ on tau, CQ may shed light on possible AD therapeutics.

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Section: Discussionmentioning

confidence: 99%

Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein

Lin

Zhu

Kanaan

et al. 2021

IJMS

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“…All participants in the program visited or were referred to our clinic for the treatment of menopausal symptoms. Of these, 494 responded to the Menopausal Health-Related Quality of Life Questionnaire (MHR-QOL) [ 7 ] and the brief-type self-administered dietary history questionnaire (BDHQ) [ 8 , 9 ]. The 46 patients treated with hormone replacement therapy, 35 patients younger than 40 years or older than 59 years, and 4 patients with unknown menopausal status were excluded, leaving 409 patient records included for analysis.…”

Section: Methodsmentioning

confidence: 99%

“…The MHR-QOL, developed and validated in our clinic [ 7 ], is a modification of the Women’s Health Questionnaire and other questionnaires [ 10 , 11 , 12 ]. Physical and psychological symptoms were scored on a 4-point Likert scale based on the frequency of symptoms.…”

Section: Methodsmentioning

confidence: 99%

The Inverse Correlation of Isoflavone Dietary Intake and Headache in Peri- and Post-Menopausal Women

et al. 2022

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This study investigated the relationship between headache and dietary consumption of a variety of nutrients in middle-aged women. This cross-sectional analysis used first-visit records of 405 women aged 40–59 years. The frequency of headaches was assessed using the Menopausal Health-Related Quality of Life Questionnaire. Of the 43 major nutrient intakes surveyed using the brief-type self-administered diet history questionnaire, those that were not shared between women with and without frequent headaches were selected. Multiple logistic regression analysis was used to identify nutrients independently associated with frequent headaches. After adjusting for background factors related to frequent headache (vasomotor, insomnia, anxiety, and depression symptoms), the estimated dietary intake of isoflavones (daidzein + genistein) (mg/1000 kcal/day) was negatively associated with frequent headaches (adjusted odds, 0.974; 95% confidence interval, 0.950–0.999). Moreover, the estimated isoflavone intake was not significantly associated with headache frequency in the premenopausal group, whereas it significantly correlated with that in the peri- and post-menopausal groups. Headache in peri- and post-menopausal women was inversely correlated with the dietary intake of isoflavones. Diets rich in isoflavones may improve headaches in middle-aged women.

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“…Li et al reported that excessive copper intake could increase ceruloplasmin and raise oxidative stress, which led to a lowering of cognitive performance [37]. It was reported that high dietary copper intake (10 mg/kJ) would increase forgetfulness by 1.25-fold in elderly women [38]. A previous prospective study showed that a high calcium and vitamin D intake (1200 mg/day and 800 IU/day) resulted in better cognitive performance than the low-dosage group (600 mg/day and 400 IU/day) [39].…”

Section: Nutrients and Cognitive Impairmentmentioning

confidence: 99%

Evaluation of Dietary Intake in Individuals with Mild Cognitive Impairment

Nien,

Lin,

et al. 2023

Nutrients

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The phase of mild cognitive impairment (MCI) holds significant importance for postponing the onset of dementia. Therefore, MCI has become a central focus in research related to dementia prevention. The purpose of this study was to investigate the dietary intake and dietary patterns of MCI patients in Taiwan. In total, 40 subjects were enrolled in this cross-sectional study that was conducted from July 2019 to September 2021 at the Linkou Chang Gung Memorial Hospital. The results of the clinical dementia rating (CDR) and mini-mental state examination (MMSE) were obtained from medical records. Participants were divided into two groups: a healthy group (MMSE ≥ 26 points, CDR = 0) and an MCI group (MMSE ≥ 26 points, CDR = 0.5). Results indicated that the MCI group had significantly higher copper and lower low-fat meat intake compared to the healthy group. Furthermore, the high MIND (Mediterranean dietary approaches to stop hypertension intervention for neurodegenerative delay) diet score represented a lower risk of MCI. After adjusting for age, gender, diabetes mellitus, hypertension, and calorie intake in the multivariate regression analysis, calcium and fruit intake levels were positively associated with the MMSE, whereas low-fat meat intake was negatively associated with the CDR. In conclusion, the prevalence of MCI demonstrated a close correlation with nutrient intake, including copper and calcium. Furthermore, a MIND diet, particularly one high in n-3 polyunsaturated fatty acids, might be useful for preventing MCI. However, more extensive research with larger populations is needed to confirm this potential.

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Severity of subjective forgetfulness is associated with high dietary intake of copper in Japanese senior women: A cross‐sectional study

Cited by 4 publications

References 65 publications

Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein

Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein

The Inverse Correlation of Isoflavone Dietary Intake and Headache in Peri- and Post-Menopausal Women

Evaluation of Dietary Intake in Individuals with Mild Cognitive Impairment

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