Sevoflurane activates the IL-6/HO-1 pathway to promote macrophage M2 polarization and prostate cancer lung metastasis

Yu, Fang; Bai, Tong

doi:10.1016/j.intimp.2022.109380

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Isoflurane could promote the survival and migration of human glioblastoma stem cells and bladder cancer cells [ 81 , 82 ]. Sevoflurane increased invasion and migration in glioblastoma, cervical, and prostate cancer cells [ [83] , [84] , [85] ], but not in colorectal cancer, ovarian cancer, colon cancer, breast cancer, and lung cancer cells [ [86] , [87] , [88] , [89] , [90] ]. Analogously, desflurane also showed conflicting results.…”

Section: Discussionmentioning

confidence: 99%

Effects of anesthesia on long-term survival in cancer surgery: A systematic review and meta-analysis

Tang,

Yao

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Effects of anesthesia on long-term survival in cancer surgery: A systematic review and meta-analysis

Tang,

Yao

et al. 2024

Heliyon

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Lidocaine combined with general anesthetics impedes metastasis of breast cancer cells via inhibition of TGF-β/Smad-mediated EMT signaling by reprogramming tumor-associated macrophages

Seok Han,

Ko,

Seok Park

et al. 2024

International Immunopharmacology

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Inhalation Anesthetics Play a Janus-Faced Role in Self-Renewal and Differentiation of Stem Cells

Hao,

Li,

Gao

et al. 2024

Biomolecules

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Inhalation anesthesia stands as a pivotal modality within clinical anesthesia practices. Beyond its primary anesthetic effects, inhaled anesthetics have non-anesthetic effects, exerting bidirectional influences on the physiological state of the body and disease progression. These effects encompass impaired cognitive function, inhibition of embryonic development, influence on tumor progression, and so forth. For many years, inhaled anesthetics were viewed as inhibitors of stem cell fate regulation. However, there is now a growing appreciation that inhaled anesthetics promote stem cell biological functions and thus are now regarded as a double-edged sword affecting stem cell fate. In this review, the effects of inhaled anesthetics on self-renewal and differentiation of neural stem cells (NSCs), embryonic stem cells (ESCs), and cancer stem cells (CSCs) were summarized. The mechanisms of inhaled anesthetics involving cell cycle, metabolism, stemness, and niche of stem cells were also discussed. A comprehensive understanding of these effects will enhance our comprehension of how inhaled anesthetics impact the human body, thus promising breakthroughs in the development of novel strategies for innovative stem cell therapy approaches.

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Sevoflurane activates the IL-6/HO-1 pathway to promote macrophage M2 polarization and prostate cancer lung metastasis

Cited by 3 publications

References 36 publications

Effects of anesthesia on long-term survival in cancer surgery: A systematic review and meta-analysis

Effects of anesthesia on long-term survival in cancer surgery: A systematic review and meta-analysis

Lidocaine combined with general anesthetics impedes metastasis of breast cancer cells via inhibition of TGF-β/Smad-mediated EMT signaling by reprogramming tumor-associated macrophages

Inhalation Anesthetics Play a Janus-Faced Role in Self-Renewal and Differentiation of Stem Cells

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