Sevoflurane anaesthesia for one-lung ventilation with PEEP to the dependent lung in sheep: effects on right ventricular function and oxygenation

Fujita, Yoshihisa; Yamasaki, Takashi; Takaori, M; Sekioka, Kiyotsugu

doi:10.1007/bf03009609

Cited by 25 publications

(14 citation statements)

References 21 publications

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“…Minimally invasive surgery techniques, including thoracoscopy, are quickly gaining ground in human and veterinary medicine. Until recently, few studies were available about the applicable ventilation techniques for anaesthesia of dogs, pigs, sheep and horses during thoracoscopy (Fujita et al., 1993; Jones et al., 1993; Faunt et al., 1998; Vachon and Fischer, 1998; Peroni et al., 2000). Thoracoscopy requires general anaesthesia in dogs, sheep and pigs, whereas the technique can be performed in sedated standing horses.…”

Section: Discussionmentioning

confidence: 99%

“…During OLV selective ventilation of one lung is applied for which specific intubation, including double‐lumen tubes, endobronchial intubation, or bronchial blockers, is necessary. Positioning is technically difficult in dogs and sheep (Muneyuki et al., 1983; Fujita et al., 1993; Cantwell et al., 2000). Due to malpositioning (up to 30%) in men routine bronchoscopy after double‐lumen tube or bronchial blocker placement is certainly recommended.…”

Section: Discussionmentioning

confidence: 99%

“…2000). General anaesthesia is necessary to perform thoracoscopy in these smaller animals (Fujita et al., 1993; Jones et al., 1993; Faunt et al., 1998).…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Intrathoracic Pressure During Continuous Two‐Lung Ventilation for Thoracoscopy on the Cardiorespiratory Parameters in Sevoflurane Anaesthetized Dogs

Polis

Gasthuys

Gielen

et al. 2002

Journal of Veterinary Medicine Series A

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The cardiopulmonary effects of different levels of carbon dioxide insufflation (3, 5 and 2 mm Hg) under two-lung ventilation were studied in six sevoflurane (1.5 minimum alveolar concentration; MAC) anaesthetized dogs during left-sided thoracoscopy. An arterial catheter, Swan-Ganz catheter and multianaesthetic gas analyser were used to monitor the cardiopulmonary parameters during the experiment. Baseline data were obtained before intrathoracic pressure elevation and the measurements were repeated at intervals after left lung collapse induced by insufflation with carbon dioxide gas. The intrapleural pressure levels used were 3, 5 and 2 mm Hg. Arterial blood pressures, cardiac index, stroke index, left and right ventricular stroke work index, arterial haemoglobin saturation, arterial oxygen tension and systemic vascular resistance decreased significantly during hemithorax insufflation, whereas heart rate, right atrial pressure, mean, systolic and diastolic pulmonary arterial pressure, pulmonary capillary wedge pressure, pulmonary vascular resistance and arterial carbon dioxide tension significantly increased during intrapleural pressure elevation. Although carbon dioxide insufflation into the left hemithorax with an intrapleural pressure of 2-5 mm Hg compromises cardiac functioning in 1.5 MAC sevoflurane anaesthetized dogs, it can be an efficacious adjunct for thoracoscopic procedures. Intrathoracic view was satisfactory with an intrapleural pressure of 2 mm Hg. Therefore, the intrathoracic pressure rise during thoracoscopy with two-lung ventilation should be kept as low as possible. Additional insufflation periods should be avoided, since a more rapid and more severe cardiopulmonary depression can occur.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Effects of Intrathoracic Pressure During Continuous Two‐Lung Ventilation for Thoracoscopy on the Cardiorespiratory Parameters in Sevoflurane Anaesthetized Dogs

Polis

Gasthuys

Gielen

et al. 2002

Journal of Veterinary Medicine Series A

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“…No differences between isoflurane and sevoflurane were detected. 15 They concluded that, although sevoflurane caused a dose-dependent depression of right ventricular function, it can be safely used during OLV. We compared the effects on oxygenation of isoflurane or sevoflurane in humans.…”

Section: Discussionmentioning

confidence: 99%

Arterial oxygenation during one lung ventilation

et al. 1997

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Purpose: To compare the effects of isoflurane and sevoflurane on arterial oxygenation and middle cerebral artery blood flow velocity during one lung ventilation. Methods: This was a randomized, crossover study in 20 patients undergoing thoracotomy for oesophageal cancer and scheduled for long term one lung ventilation (OLV). They were randomized to one of two groups: group A, firstly isoflurane was administered followed by sevoflurane, and then isoflurane was resumed; group 13, the order of the administration was reversed, Arterial blood gas samples were drawn at the start of OLV, 30 and 60 min after the initiation of OLV and the end of OLV (the change of volatile anesthetics was done 30 and 60 min after the start of OLV). Middle cerebral artery (MCA) was monitored continuously with the probe positioned over the temporal bone window. This probe transmitted 2 MHZ wave Doppler signals. Time-averaged MCA blood flow velocity was calculated from the signals. Results: The PaO2 values decreased 30 min after the start of OLV (364.4 +_ 33.4 mmHg vs 179.0 +_ 19.5. and 338,7 _+ 24.8 mmHg vs 139.7 ___ 19.9 in groups A and 13 respectively), but there was no difference between the groups, Blood flow velocity of MCA did not change after the start of OLV (53. I ___ 3.2, 55.9 _+ 3.0, 56.4 ___ 2,4, and 54. I _+_ 1.9 vs 50.8 _+ 2, I, 50.7 +--2.4, 53.7 • 1.5, 50.8 -+ 2.2 cm'sec-' in groups A and 13 respectively): there was no difference between the groups. (P < 0.05). Conclusion: In clinical practice, the selection of either isoflurane and sevoflurane for OLV was of no difference in terms of the artenal blood oxygenation. With both agents MCA blood flow velocity was maintained dudng OLV.

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“…(19)(20)(21) Sevoflurane causes a dose-dependent depression of right ventricular function. (22) Propofol is believed to cause a reduction in systolic and diastolic arterial pressures by lowering SVRI and afterload. (23) Some studies on people and animals showed that it had no influence on CI, (23)(24)(25) while in others it caused a reduction in CI.…”

Section: Discussionmentioning

confidence: 99%

Haemodynamic changes after induction of anaesthesia with sevoflurane vs. propofol

Potočnik

Jankovič

Štupnik

et al. 2011

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Inhalation induction with sevoflurane would appear to offer several objective advantages compared to induction with propofol. In our study, the hemodynamic results of sevoflurane vs. propofol induction in patients undergoing thoracotomy were studied. In a prospective, randomized, blinded study 24 patients were randomly allocated to one of 2 groups: sevoflurane (S) and propofol (P) (n=12 each). For hemodynamic monitoring the LIDCO plus system was used. Patients in group S were induced into anaesthesia with sevofluran, remifentanil and vecuronium, whereas patients in group P with propofol, remifentanil and vecuronium. The anaesthesia was maintained with the same agents. Hemodynamic stability was guided using a special algorithm. The goal was oxygen delivery index (DO2I) > 500 mL min-1 m-2. According to the algorithm, patients received colloids or vasoactive drugs. Hemodynamic parameters were recorded before induction, 3 minutes after induction and 3 minutes after intubation and commencement of one lung ventilation. The consumption of vasoactive drugs and colloids and the time from the beginning of induction to intubation were documented.No statistically significant differences in measured hemodynamic parameters, remifentanil and colloid consumption between the S and P group were found. In group P, statistically more ephedrine was used (S: 4.2, P:20.8, p<0.05). Patients undergoing thoracotomy induced with sevoflurane are circulatory more stable than those induced with propofol. IZTOK POTOëNIK ( ) •

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Sevoflurane anaesthesia for one-lung ventilation with PEEP to the dependent lung in sheep: effects on right ventricular function and oxygenation

Abstract: This study was undertaken to examine the effect of sevoflurane on right ventricular function, the safety of sevoflurane for onelung ventilation and the effects of PEEP (positive end-expiratory pressure) to the dependent lung in this model [1195][1196][1197][1198][1199][1200]

Cited by 25 publications

References 21 publications

The Effects of Intrathoracic Pressure During Continuous Two‐Lung Ventilation for Thoracoscopy on the Cardiorespiratory Parameters in Sevoflurane Anaesthetized Dogs

The Effects of Intrathoracic Pressure During Continuous Two‐Lung Ventilation for Thoracoscopy on the Cardiorespiratory Parameters in Sevoflurane Anaesthetized Dogs

Arterial oxygenation during one lung ventilation

Haemodynamic changes after induction of anaesthesia with sevoflurane vs. propofol

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