Sevoflurane and Isoflurane Protect against Bronchospasm in Dogs

Mitsuhata, H; Saitoh, Jin; Shimizu, R; Takeuchi, Haruhiko; Hasome, Naoki; Horiguchi, Yuji

doi:10.1097/00000542-199411000-00017

Cited by 60 publications

(26 citation statements)

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“…These changes in hemodynamic variables and peak airway pressure are compatible to those Barsen et al (7) and Mitsuhata et al (18)(19)(20)(21)(22)(23)(24) reported in their studies using the similar experimental models. Their studies, however, focused on functional changes of respiratory and hemodynamic parameters associated with anaphylactic shock, and detailed descriptions of blood flow distribution are lacking.…”

Section: Discussionsupporting

confidence: 91%

“…This is probably due to its effects in inhibiting histamine and reducing the blood levels of granulocyte elastase as an indicator of airway inflammation and thromboxane B 2 (8) as an indicator of airway contraction mediator. Isoflurane, the anesthetic used in this experiment, is effective at 1 MAC in treating bronchospasm during anaphylactic shock (23). However, the concentration of the agent used in this study ranged from 0.3 to 0.5 MAC, so its effect should have been minimal.…”

Section: Discussionmentioning

confidence: 95%

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Urinary Trypsin Inhibitor Improves Peripheral Microcirculation and Bronchospasm Associated with Systemic Anaphylaxis in Rabbits In Vivo

Komori¹,

Takada²,

Tomizawa

et al. 2003

Shock

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Using intravital microscopy of the rabbit ear for quantitative studies of microvascular dynamics, we examined the impact of urinary trypsin inhibitor (UTI), a proteolytic enzyme inhibitor, on microvascular changes during immune complex-mediated anaphylaxis. A total of 50 rabbits, previously sensitized with horse serum, were anesthetized and mechanically ventilated with pentobarbital and isoflurane for the intravital microscopy. Rabbits were then challenged with intravenous injection of horse serum to induce systemic anaphylaxis. One minute after the challenge, each rabbit was randomly assigned to receive saline (group C), 50,000 units x kg(-1) of UTI (group U1), or 150,000 units x kg(-1) (group U2). There were no statistical differences between hemodynamic variables, including heart rate (HR), mean arterial pressure (MAP), and central venous pressure (CVP), among the survivors in each treatment group. Peak inspiratory pressure rose in all three groups but at a much higher rate in group C (P < 0.05). In contrast with the moderate effects of UTI on the above parameters, microscopic evaluation revealed a substantial difference among treatment groups: upon the initiation of anaphylaxis, the arteriole started to reduce in diameter, but UTI prevented vasoconstriction in the arteriole in a dose-dependent manner. Similar results were observed with blood flow velocity. Because flow rate was calculated as the product of blood flow velocity and vascular cross-sectional area proportional to the square of the vessel diameter, these results indicate that UTI preserves microvascular flow rate during anaphylaxis. Rabbit ear microcirculation is highly preserved in the UTI-treated groups during systemic anaphylactic shock.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 95%

Urinary Trypsin Inhibitor Improves Peripheral Microcirculation and Bronchospasm Associated with Systemic Anaphylaxis in Rabbits In Vivo

Komori¹,

Takada²,

Tomizawa

et al. 2003

Shock

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“…The adverse effects of halogenated volatile anaesthetics associated with mask induction, as experienced clinically in animals, are characterised by apnoea, breath-holding, laryngospasm, bronchoconstriction or body movements [7,9,10]. Some of these induction-related complications (e.g., struggling) also accompany mask induction in rabbits [2,4] and dogs [8].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the arterial blood gas, arterial oxyhaemoglobin saturation and end-tidal carbon dioxide tension during sevoflurane or isoflurane anaesthesia in rabbits

Topal

Gül

2006

Ir Vet J

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The effects of sevoflurane or isoflurane on arterial blood gas, arterial oxyhaemoglobin saturation and end-tidal CO2 tension were monitored during induction and maintenance of anaesthesia in 10 premedicated New Zealand White (NZW) rabbits.For induction, the anaesthetic agents were delivered via a face-mask. After induction was completed, an endotracheal tube was introduced for maintenance of anaesthesia for a period of 90 minutes. Changes in heart rate, respiratory rate, arterial blood gas, arterial oxyhaemoglobin saturation, blood pH and end-tidal CO2 tension were recorded. Although sevoflurane and isoflurane produce similar cardiopulmonary effects in premedicated rabbits, sevoflurane provides a smoother and faster induction because of its lower blood/gas partition coefficient. Thus sevoflurane is probably a more suitable agent than isoflurane for mask induction and maintenance. Its lower blood solubility also makes sevoflurane more satisfactory than isoflurane for maintenance of anaesthesia because it allows the anaesthetist to change the depth of anaesthesia more rapidly.

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“…Sevoflurane has a direct bronchodilating effect. It can suppress histamine-induced bronchospasm [71,72]. Interestingly, sevoflurane has a non-pungent odour and does not irritate the airways [11].…”

Section: Respiratory Effectsmentioning

confidence: 99%

Sevoflurane inside and outside the operating room

Michel

Constantin

2009

Expert Opinion on Pharmacotherapy

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Background: Sevoflurane is often presented as a near-perfect anaesthetic. After 10 years in the operating room, new uses are emerging outside. Objective: To remind readers of the principal characteristics of sevoflurane, to affirm its usefulness for day-case anaesthesia and to consider the recent new uses. Methods: The discussion of the physical properties, pharmacokinetics, metabolism, mechanisms of action and clinical effects is based on classic, essential papers. Recent literature concerning emerging utilizations of sevoflurane was analysed. Results: Sevoflurane presents many benefits with minimum inconvenience. It allows rapid inhalation induction, maintenance and rapid recovery. It has little toxicity and its haemodynamic and respiratory depressive effects are moderate and well tolerated. It is already widely use for sedation for magnetic resonance imaging in children. Its use in paediatric or adult intensive care could improve the management of pain and sedation.

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Sevoflurane and Isoflurane Protect against Bronchospasm in Dogs

Cited by 60 publications

References 0 publications

Urinary Trypsin Inhibitor Improves Peripheral Microcirculation and Bronchospasm Associated with Systemic Anaphylaxis in Rabbits In Vivo

Urinary Trypsin Inhibitor Improves Peripheral Microcirculation and Bronchospasm Associated with Systemic Anaphylaxis in Rabbits In Vivo

Comparison of the arterial blood gas, arterial oxyhaemoglobin saturation and end-tidal carbon dioxide tension during sevoflurane or isoflurane anaesthesia in rabbits

Sevoflurane inside and outside the operating room

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