Sevoflurane-induced oxidative stress and cellular injury in human peripheral polymorphonuclear neutrophils

Wong, Chung Hang; Liu, Tsan‐Zon; Chye, Soi-Moi; Lu, Fung‐Jou; Liu, Yachen; Lin, Zhao-Cen; Chen, Ching‐Hsein

doi:10.1016/j.fct.2006.03.004

Cited by 51 publications

(45 citation statements)

References 43 publications

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“…Sevoflurane metabolism is also associated with the formation of reactive products, which could directly trigger the generation of peroxynitrite and increase peroxides and nitric oxide (3). Its genotoxicity has been previously related to the generation of reactive oxygen species (28). Another important fact, which has to be mentioned, is that compound A may be an alkylating agent (4,17).…”

Section: Discussionmentioning

confidence: 99%

Sevoflurane and isoflurane genotoxicity in kidney cells of mice

Brozović

Oršolić

Rozgaj

et al. 2017

Archives of Industrial Hygiene and Toxicology

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The aim of this study was to evaluate the DNA damage and repair in kidney cells of Swiss albino mice after repeated exposure to sevoflurane and isoflurane and compare their detrimental effects. We used the alkaline comet assay to establish the genetic damage and measured three parameters: tail length, tail moment, and tail intensity of comets. These parameters were measured immediately after exposure to the above mentioned inhalation anaesthetics, two hours, six hours, and 24 hours later and were compared with the control group. Mean values of all three parameters were significantly higher in experimental groups compared to the control group. DNA damage in kidney cells of mice exposed to sevoflurane increased continuously before it reached its peak 24 hours after exposure. Isoflurane induced the highest DNA damage two hours after exposure. Levels of DNA damage recorded 24 h after cessation of exposure to both tested compounds suggest that sevoflurane was slightly more genotoxic than isoflurane to kidney cells of mice. According to these results, the currently used volatile anaesthetics sevoflurane and isoflurane are able to damage DNA in kidney cells of mice. Such findings suggest a possibility for similar outcomes in humans and that fact must be taken into account in everyday clinical practice.

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Section: Discussionmentioning

confidence: 99%

Sevoflurane and isoflurane genotoxicity in kidney cells of mice

Brozović

Oršolić

Rozgaj

et al. 2017

Archives of Industrial Hygiene and Toxicology

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“…Sevoflurane is biotransformed by enzyme CYP 2 E 1 which also produces ROS, including superoxide anions (O 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radical (OH − ), which are highly reactive [22]. In this context, Wong et al described apoptosis in neutrophils produced by exposure to sevoflurane in a dose-dependent manner, related to a ROS intracellular increase [23]. In contrast, Lee et al stated that volatile anesthetic agents, in patients who underwent minor surgeries, did not affect neither oxidative stress nor inflammation [24].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Stress Response and Apoptosis on Leucocytes in TIVA versus Balanced Anesthesia

Soto¹,

Pignolo²,

Calero³

et al. 2017

OJApo

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Background: The aim of this study was to assess the stress response and apoptosis on leucocytes, in patients under two different anesthetics techniques. Methods: Thirty patients ASA I-II were prospectively randomized into two groups to receive either total intravenous anesthesia with propofolremifentanil (TIVA Group, n = 15) or balanced inhalation anesthesia with sevoflurane-remifentanil (BAL Group, n = 15). The hemodynamic response: systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) at different time points: baseline, after intubation, after skin incision and at the end of surgery, was measured along with plasma levels of lactate, glucose, cortisol and leucocytes count. The biomarkers of apoptosis (Annexin V and Propidium Iodide) in neutrophils, monocytes and lymphocytes were evaluated at baseline, intraoperatively and two hours after surgery. Results: The study groups were comparable with respect to anthropometric data. No significant intergroup differences in SBP and DBP were revealed. The HR in the BAL group was lower after intubation (p = 0.007). In both groups, lactate, plasma glucose, cortisol and leucocytes count remained stable during surgery and two hours post-operatively. In the BAL group there were significant differences in Annexin V in neutrophils, baseline moment (p = 0.010). No significant differences were found in apoptosis markers (Annexin V and Propidium Iodide) in neutrophils, monocytes and lymphocytes, at different time points. Conclusion: Both TIVA and BAL were effective in suppressing the surgical stress, without inducing apoptosis in immune cells, in patients undergoing VCL.

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“…Se vof lu ra ne, at a cli ni cally at ta i nab le con cen tra ti on, has be en repor ted to sig ni fi cantly in cre a se in tra cel lu lar fre e ra di als and NO re le a se from hu man poly morp honuc le ar (PMN) le u kocy tes. 32 Ho we ver, fen tanyl do es not ha ve the abi lity to inf lu en ce NO re le a se from hu man en dot he li al cells and has no inf lu ence on ne ut rop hil func ti on. 33,34 As a re sult, it al so lacks the abi lity to dow nre gu la te the inf lam matory res pon se as so ci a ted with sur gery.…”

Section: Anesthesiology and Reanimationmentioning

confidence: 99%

Effects of Preoperatively or Postoperatively Initiated Thoracic Epidural Analgesia in Patients Undergoing Elective Lung Surgery

Çöçelli¹,

Sarimehmetoğlu²,

Demiryürek³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: :The go al of this study was to in ves ti ga te the ef fects of pre o pe ra ti vely and pos tope ra ti vely ini ti a ted tho ra cic epi du ral anal ge si a (TE A) on oxi da ti ve stress, res pi ra tory func ti ons and pos to pe ra ti ve pa in in pa ti ents un der go ing elec ti ve lung sur gery. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : A tho ra cic epi du ral cat he ter was in ser ted in to all the pa ti ents be fo re sur gery. In Pre op-TE A Gro up (n= 15), bo lus do se of 0.175% bu pi va ca i ne and 15 µg ml -1 fen tanyl (0.1 ml kg -1 ) were ad mi nis te red pre o pe ra ti vely, fol lo wed by a con ti nu o us in fu si on of 0.125% bu pi va ca i ne and 10 µg ml -1 fen tanyl com bi na ti on (0.1 ml kg -1 h -1 ) in trao pe ra ti vely. In Pos top-TE A Gro up (n= 15), no me di ca ti on was ad mi nis te red vi a the epi du ral cat he ter pre o pe ra ti vely. Pos to pe ra ti ve anal ge si a was ma in ta i ned with pa ti ent-con trol led epi du ral anal ge si a (PCA) in both gro ups for 48 h. We as ses sed pe ro pe ra ti ve IV anal ge sic re qu irt ment and pos to pe ra ti ve pa in and anal ge sic con sump ti on, oxi da ti ve stress, he art ra te, blo od pres su re, res pi ra tory func ti ons and si de ef fects. The pos to pe ra ti ve in ten si ve ca re unit and hos pi tal stay du ra ti ons we re re cor ded. Stu dent's t-test, χ 2 -test, Mann-Whit ney U test, and Wil co xon's sig ned rank test we re used for gro up com pa ri sons and sta tis ti cal conc lu si ons. R Re e s su ul lt ts s: : Vi su al ana lo gu e sco res we re al ways hig her du ring co ug hing and at rest, pe ri o pe rati ve he art ra te was increased in Pos top-TE A Gro up (p< 0.05). To tal pe ro pe ra ti ve fen tanyl re qu i re ment and pos to pe ra ti ve anal ge sic con sump ti on vi a PCA we re lo wer in Pre op-TE A Gro up (p< 0.05). Res pi ra tory func ti on tests we re dec re a sed in both gro ups when com pa red to the pre o pe ra ti ve va lu es (p< 0.05), but the dif fe ren ces we re small in Preop-TEA group (p< 0.05). No mar ked ef fect on oxi da ti ve stress was determined and shor ter length of stay in ICU and hos pi tal shorter in Pre op-TE A Gro up (p< 0.05). C Co on nc c l lu u s si i o on n: : The se re sults sug gest that pre o pe ra ti vely ini ti a ted TE A pro vi des bet ter pos to pe ra ti ve pa in re li ef with impro ving the out co me and shor te ning in ten si ve ca re and hos pi tal stay in pa ti ents un der go ing elec ti ve lung sur gery. Ho we ver, TE A had no mar ked ef fect on oxi da ti ve stress in our study. K Ke ey y W Wo or rd ds s: : Anal ge si a, epi du ral; tho ra co tomy; pa in, pos to pe ra ti ve; oxi da ti ve stress Ö ÖZ ZE ET T A Am ma aç ç: : Bu ça lış ma nın ama cı elek tif ak ci ğer cer ra hi si olan has ta lar da ok si datif stress, so lu num fonksi yon la rı ve pos to pe ra tif ağ rı üze ri ne pre o pe ra tif ve pos to pe ra tif baş la tı lan to ra sik epi du ral anal je zi nin (TE A) et ki le ri ni araş tır mak tı. G Ge er re eç...

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Sevoflurane-induced oxidative stress and cellular injury in human peripheral polymorphonuclear neutrophils

Cited by 51 publications

References 43 publications

Sevoflurane and isoflurane genotoxicity in kidney cells of mice

Sevoflurane and isoflurane genotoxicity in kidney cells of mice

Evaluation of Stress Response and Apoptosis on Leucocytes in TIVA versus Balanced Anesthesia

Effects of Preoperatively or Postoperatively Initiated Thoracic Epidural Analgesia in Patients Undergoing Elective Lung Surgery

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