Sevoflurane Inhibits Phorbol-Myristate-Acetate-induced Activator Protein-1 Activation in Human T Lymphocytes in Vitro : Potential Role of the p38-Stress Kinase Pathway

Loop, Torsten; Scheiermann, Patrick; Dovi-Akue, David; Mußhoff, Frank; Humar, Matjaž; Roesslein, Martin; Hoetzel, Alexander; Schmidt, René; Madea, B; Geiger, K.; Pahl, Heike L.; Pannen, Benedikt H. J.

doi:10.1097/00000542-200409000-00020

Cited by 40 publications

(35 citation statements)

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“…Protocol of A549 cell exposure to sevoflurane A549 cells in the exponential growth phase were inoculated onto plates and cultured in a CO 2 incubator (ThermoFisher Scientific, Waltham, MA) for 24 h. In accordance with the experimental protocol previously described [14,15], cell culture plates were placed in an airtight glass chamber with inlet and outlet connectors. The inlet port of the chamber was connected to the anesthesia machine (Cicero-EM 8060; Dräger, Germany), and sevoflurane was supplied into the chamber by a sevoflurane vaporizer (Sevorane; Abbott, Abbot Park, IL) attached to the anesthesia machine.…”

Section: Cell Line and Cell Culturementioning

confidence: 99%

Sevoflurane inhibits invasion and migration of lung cancer cells by inactivating the p38 MAPK signaling pathway

Liu

Yang

et al. 2012

J Anesth

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Section: Cell Line and Cell Culturementioning

confidence: 99%

Sevoflurane inhibits invasion and migration of lung cancer cells by inactivating the p38 MAPK signaling pathway

Liu

Yang

et al. 2012

J Anesth

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“…3 IV anesthetics except propofol and volatile anesthetics are known to augment surgically induced immunosuppression. [7][8][9][10] Ketamine by its adrenergic stimulatory properties promote tumourmetastasis.Propofol has no effect on metastasis due to its weak beta adrenergic antagonist properties. The antitumoural protective effect of propofol has been suggested due to its inhibitory effect on cycloxygenase 2 and PGE2 in cancer cells as well as stimulation of immunity response.…”

Section: Discussionmentioning

confidence: 99%

“…The antitumoural protective effect of propofol has been suggested due to its inhibitory effect on cycloxygenase 2 and PGE2 in cancer cells as well as stimulation of immunity response. [7][8][9][10] Opioids by inhibiting cellular and humeral immunity and due to their proangiogenic effect by activation of Mu opioid receptors found in vascular endothelial cells may promote metastasis. 11,12 But the pain relief induced by them can attenuate the increased susceptibility for metastasis induced by surgery.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the effects of drugs and techniques used in anesthesia on tumour recurrence, metastasis and survival in ovarian serous adenocarcinoma

Sudha

Koshy

2016

Int Surg J

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INTRODUCTIONSurgical removal of the primary tumour is the best treatment option for solid tumours.Studies have shown that cancer related deaths occur mostly due to metastasis. 1 Perioperative period is very critical as a number of factors during this period promote development of metastasis.2 Compromised immune defense and tumour seeding leads to increased susceptibility to tumour metastasis during perioperative period. 3,4 In this context there is increasing interest on the effect of anesthesia and anesthesia techniques in tumour progression suggesting an increased role for the anesthetist in improving long term outcome after cancer surgery. ABSTRACTBackground: Numerous factors affect the risk of recurrence and metastasis after cancer surgery. Studies have observed that anaesthetic techniques have effects on tumour recurrence. Methods: Medical records of newly diagnosed ovarian serous adenocarcinoma patients who underwent radical hysterectomy with bilateral salpingoopherectomy from 1995-2008 were analysed for the effect of anaesthetic techniques and drugs on tumour recurrence & metastasis free survival rate and mortality rate. Univariate association between overall survival and anaesthesia technique was assessed using Kaplan-Meier survival estimates and Cox regression. Multivariate association was tested after adjusting potential confounding factors. Results: The overall survival rate (RR at 95% CI=3.16(1.79-5.60) was significantly better in patients who received regional anaesthesia for surgery than those who had general anaesthesia. Other factors significantly associated with overall survival rate in univariable analysis were,perioperative blood transfusion,preoperative Ca 125 level, FIGO stage, tumour size and lymphatic metastasis.Kaplan Meier survival curve showed that regional anesthesia group had higher overall survival rate.Recurrence rate did not show significant difference in univariable(Odds 95% CI 1.42 P = 0.273)and multivariable(Odds 95% CI = 0 P = 0.846) analysis.Al1the 18 patients who had metastasis underwent surgery under GA. Conclusions: This study showed marked increase in overall survival rate in patients who underwent surgery under regional anaesthesia when compared to those who had surgery under general anaesthesia. Prospective randomized control trials are needed for better evaluation.

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“…Thus, sevoflurane likely exerts anti-inflammatory activities on various types of cells. Notably, it has been suggested that sevoflurane exerts an anti-inflammatory action via the mechanisms involving the reduction of mRNA and protein levels of the proinflammatory transcription factors NF-κB and AP-1 (35,37).…”

Section: Discussionmentioning

confidence: 99%

Effects of nitrous oxide on the production of cytokines and chemokines by the airway epithelium during anesthesia with sevoflurane and propofol

Kumakura

Yamaguchi

Sugasawa

et al. 2013

Molecular Medicine Reports

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Abstract. The aim of this study was to evaluate the effects of nitrous oxide (a gaseous anesthetic) on the in vivo production of inflammatory cytokines and chemokines by the airway epithelium, when combined with sevoflurane or propofol. Subjects undergoing simple or segmental mastectomy were randomly assigned to the sevoflurane and nitrous oxide, sevoflurane and air, propofol and nitrous oxide, or propofol and air group (all n=13). Epithelial lining fluid (ELF) was obtained using the bronchoscopic microsampling method prior to and following the mastectomy to enable measurement of the pre-and post-operative levels of certain inflammatory cytokines and chemokines using a cytometric bead array system. Notably, the levels of interleukin (IL)-1β, IL-8 and monocyte chemotactic protein-1 (MCP-1) in the ELF were significantly increased following the operations which involved the inhalation of sevoflurane and nitrous oxide, although the levels of these molecules were not significantly changed by the inhalation of sevoflurane and air. Furthermore, the IL-12p70 levels were significantly reduced in the ELF following the operations that involved the inhalation of sevoflurane and air, although the IL-12p70 levels were not significantly changed by the inhalation of nitrous oxide and sevoflurane. These observations suggest that the combination of sevoflurane and nitrous oxide induces an inflammatory response (increased production of IL-1β, IL-8 and MCP-1) and suppresses the anti-inflammatory response (reduced production of IL-12p70) in the local milieu of the airway. Thus, the combination of these compounds should be carefully administered for anesthesia. IntroductionGlobally, >200 million major surgical procedures are undertaken annually (1), and nitrous oxide is widely used in anesthesia, often administered at an inspired concentration of ~60-70% (2-5). Nitrous oxide has achieved marked longevity as an anesthetic, having been used widely since 1844 (6). However, the low toxicity of modern anesthetic agents and the accumulating evidence on the adverse effects of nitrous oxide render the continued use of nitrous oxide in anesthesia controversial (7-10). A number of the adverse effects of nitrous oxide result from the irreversible inactivation of vitamin B 12 , which inhibits methionine synthase, folate metabolism and deoxyribonucleic acid synthesis (7,8). This mechanism explains the megaloblastic anemia and neurologic toxicity associated with prolonged nitrous oxide administration (11,12), and the possible risk of teratogenicity, immunodeficiency and impaired wound healing (7,13,14). In addition, the inhibition of methionine synthase is associated with increased plasma homocysteine concentrations (15,16) which may increase the risk of post-operative cardiovascular complications (15). Furthermore, nitrous oxide impairs cerebral blood flow-activity coupling (10), and worsens the air space conditions (such as pneumothorax and air embolism) and bowel distension (8,9). Nitrous oxide is also a risk factor for post-operative nausea an...

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Sevoflurane Inhibits Phorbol-Myristate-Acetate-induced Activator Protein-1 Activation in Human T Lymphocytes in Vitro : Potential Role of the p38-Stress Kinase Pathway

Abstract: The data demonstrate that sevoflurane is a specific inhibitor of AP-1 and may thus provide a molecular mechanism for the antiinflammatory effects associated with sevoflurane administration.

Cited by 40 publications

References 52 publications

Sevoflurane inhibits invasion and migration of lung cancer cells by inactivating the p38 MAPK signaling pathway

Sevoflurane inhibits invasion and migration of lung cancer cells by inactivating the p38 MAPK signaling pathway

Analysis of the effects of drugs and techniques used in anesthesia on tumour recurrence, metastasis and survival in ovarian serous adenocarcinoma

Effects of nitrous oxide on the production of cytokines and chemokines by the airway epithelium during anesthesia with sevoflurane and propofol

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