Sevoflurane pretreatment prevents lipopolysaccharide (LPS)-induced acute lung injury in rats through up-regulated heme oxygenase-1 (HO-1) expression

Ping, Zhaoshuang; Wu, Jiao; Zhong, Zhang

doi:10.5897/ajpp11.311

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Analgesia may reduce postoperative complications and speed recovery when well done (Montané et al, 2010;Parhizkar et al, 2011;Canbek et al, 2011;Ping et al, 2011). It allows for early ambulation and motion and facilitates the exchange of dressings and bowel motility, *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Comparison between S-ketamine and clonidine in caudal analgesia

Ribeiro¹

2011

Afr. J. Pharm. Pharmacol.

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We aimed to compare the analgesic efficacy of the caudal administration of a combination of preservative free S-ketamine or clonidine with bupivacaine in children. The study included 51 children aged between 3 and 8 years old and physical status between I and II according to: American Society of Anesthesiologist. They were randomly divided into three groups: Group B -bupivacaine 0.25%, 0.75 ml/kg without adrenaline; Group C -bupivacaine 0.25%, 0.75 ml/kg without adrenaline and clonidine 1 µg/kg and; Group K -bupivacaine 0.25%, 0.75 ml/kg without adrenaline and S-ketamine 0.5 mg/kg without conservative. In this study, medication was not used before anesthesia. The evaluation of postoperative analgesia was accomplished through the pain scale of Ouch, the motor blockade assessed by modified Bromage scale and the level of sedation through the three-point scale. The combination of caudal S-ketamine and clonidine with bupivacaine prolonged the duration of postoperative analgesia (p < 0.05) compared to bupivacaine alone. Regarding hemodynamic parameters, bupivacaine associated with clonidine (C) and bupivacaine associated with S-ketamine (K) groups presented diastolic blood pressure changes in the postoperative period. Respiratory rate, regardless of group, showed significant differences over time (p <0.05). The studied groups showed non significant changes in the degree of motor blockade and sedation score and we observed no clinical significant side effects. S-ketamine and clonidine associated with bupivacaine prolongs postoperative analgesia without clinically significant side effects.

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Section: Introductionmentioning

confidence: 99%

Comparison between S-ketamine and clonidine in caudal analgesia

Ribeiro¹

2011

Afr. J. Pharm. Pharmacol.

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“…Sevoflurane was found to be associated with many side effects on other body regions (Ping et al, 2011;Xie et al, 2012). However, whether sevoflurane administration can cause specific loss of cognitive functions is yet unknown.…”

Section: Introductionmentioning

confidence: 99%

The effects of sevoflurane on short memory impairment in mice

Zhang¹

2012

Afr. J. Pharm. Pharmacol.

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This study was aimed at investigating the effects of sevoflurane on short memory impairment and the relative synaptic mechanism. To achieve this, at 12, 24 and 72 h after the mice were exposed to 1.5% sevoflurane for 1 h, the spontaneous alternation and locomotor activity was assessed by Y maze and the short term potentiation (STP) were measured with extracellular recording technique in hippocampal slices. Results indicated that at 12 h after administration with sevoflurane in vivo, the spontaneous alternation and locomotor activity decreased significantly compared with that of control group, and the population spike amplitude after induction of STP decreased significantly in hippocampal slices. However, there was no difference at 24 and 72 h. After administration with sevoflurane in vitro, the basic or titanic population spike amplitude decreased significantly in hippocampal slices, but the amplitude could be recovered after wash-out. Therefore, sevoflurane impaired the short memory by suppressing synaptic transmission in the near future but not the long future.

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Sevoflurane pretreatment prevents lipopolysaccharide (LPS)-induced acute lung injury in rats through up-regulated heme oxygenase-1 (HO-1) expression

Cited by 2 publications

References 21 publications

Comparison between S-ketamine and clonidine in caudal analgesia

Comparison between S-ketamine and clonidine in caudal analgesia

The effects of sevoflurane on short memory impairment in mice

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