2020
DOI: 10.1016/j.jece.2020.104306
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Sewage analysis as a tool for the COVID-19 pandemic response and management: the urgent need for optimised protocols for SARS-CoV-2 detection and quantification

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Cited by 184 publications
(193 citation statements)
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References 99 publications
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“…These findings are in agreement with reported observations from previous studies ( D'Aoust et al, 2021 ; Nemudryi et al, 2020 ; Peccia et al, 2020 ). This study, as opposed to an earlier study in the same region ( D'Aoust et al, 2021 ), demonstrates that strong correlations do in fact exist between viral RNA signal and the epidemiological metric of clinical daily new COVID-19 cases, as supported by several other studies ( Hart and Halden, 2020 ; Michael-Kordatou et al, 2020 ; Trottier et al, 2020 ; Wu et al, 2020 ). The moderate correlations between viral RNA signal and clinical daily new COVID-19 cases in previous work was largely attributed to inadequate resources to achieve a developed clinical testing framework early in the pandemic (lower daily # of tests).…”
Section: Results Discussion and Implicationssupporting
confidence: 75%
“…These findings are in agreement with reported observations from previous studies ( D'Aoust et al, 2021 ; Nemudryi et al, 2020 ; Peccia et al, 2020 ). This study, as opposed to an earlier study in the same region ( D'Aoust et al, 2021 ), demonstrates that strong correlations do in fact exist between viral RNA signal and the epidemiological metric of clinical daily new COVID-19 cases, as supported by several other studies ( Hart and Halden, 2020 ; Michael-Kordatou et al, 2020 ; Trottier et al, 2020 ; Wu et al, 2020 ). The moderate correlations between viral RNA signal and clinical daily new COVID-19 cases in previous work was largely attributed to inadequate resources to achieve a developed clinical testing framework early in the pandemic (lower daily # of tests).…”
Section: Results Discussion and Implicationssupporting
confidence: 75%
“…The confirmation of positive RT-qPCR signals by sequencing analysis or the use or more than one target region is highly recommended until assay specificities have been validated for environmental samples ( Kitajima et al., 2020 ; Michael-Kordatou et al., 2020 ). Despite no consensus on the best methodology to detect SARS-CoV-2, we used N2 primes and probe based on studies that described this target region as the most suitable to detect these viruses ( Nalla et al., 2020 ; Gonzalez et al., 2020 ).…”
Section: Discussionmentioning
confidence: 99%
“…Very limited data is available on the occurrence of the closely related SARS-CoV-1 in wastewater (Peiris et al 2003 ; Wang et al 2005a ; Gundy et al 2009 ; Wigginton et al 2015 ), but connections with wastewater were identified in a 2003 outbreak in Hong Kong linked to a faulty sewage system (Peiris et al 2003 ). Since the first report of SARS-CoV-2 in human waste (Holshue et al 2020 ), the presence of SARS-CoV-2 in wastewater has drawn substantial attention, and globally an increasing number of studies have detected SARS-CoV-2 in untreated and/or treated urban wastewater and wastewater treatment plants (WWTPs) to track the spatial and temporal dynamics of the virus and the removal of efficiency of wastewater treatment processes (Table 1 ) and the potential public health risks associated with SARS-CoV-2 in wastewater (Michael-Kordatou et al 2020 ). Prevalence rates ranging from 11 to 100% at a concentration up to 4.6 × 10 7 genome copies/L in untreated (raw influent), and 0 to 100% at a concentration up to 10 5 genome copies/L in treated (final effluent) wastewater have been reported (Table 1 ).…”
Section: Occurrence Of Sars-cov-2 In Wastewatermentioning
confidence: 99%