Sex-age-specific handgrip strength and mortality in an incident hemodialysis cohort: The risk explained by nutrition and comorbidities

Lopes, Marcelo Barreto; Silva, Luciana F.; Dantas, Marina A; Matos, Cácia Mendes; Lopes, Gildete Barreto; Lopes, Antônio Alberto

doi:10.1177/0391398818793088

Cited by 22 publications

(14 citation statements)

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“…21 In an incident hemodialysis cohort, HGS was found to be associated with mortality in a sex-, and age-specific manner. 22 The discrepancies in the association between HGS and MCI may be owing to sex and/or age effects; however, such detailed patient information is not currently available.…”

Section: Introductionmentioning

confidence: 99%

Sex- and age-specific mild cognitive impairment is associated with low hand grip strength in an older Chinese cohort

et al. 2020

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Background Few studies have demonstrated the impact of characteristics like age and sex on the association between hand grip strength (HGS) and mild cognitive impairment (MCI). In this cross-sectional study, we aimed to examine the effects of sex and age on the relationship between HGS and MCI. Methods We enrolled older adults age ≥60 years (n = 1009) and measured HGS and MCI in all participants. We analyzed the differences in MCI prevalence among the different variables. The role of sex and age in the association between MCI and HGS was analyzed using binary logistic regression. Results Women had significantly higher prevalence of MCI than men, as did the older group (age ≥70 years) compared with the younger group (age 60–70 years). In men, the low and middle HGS tertiles were significantly associated with MCI. In contrast, only the low tertile of HGS was associated with MCI in women. In the older group, the low tertile of HGS was significantly associated with MCI, which was not observed in the younger group. Conclusions HGS was associated with MCI in older adults, and this association was stronger in men. HGS may be useful for evaluating MCI in older adults.

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Section: Introductionmentioning

confidence: 99%

Sex- and age-specific mild cognitive impairment is associated with low hand grip strength in an older Chinese cohort

et al. 2020

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“…In summary, the difference of muscle strength between the sexes is already well known. Moreover, recent studies have proved that different races and ages are associated with different cut-off values [3,12,22,24,25].…”

Section: Discussionmentioning

confidence: 99%

Association of Handgrip Strength With Mortality in Hemodialysis Patients in Taiwan: A Prospective Cohort Study

Chu¹,

Hsu²,

Liu³

et al. 2021

Preprint

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Background:Poor muscle quality has been associated with mortality in patients undergoing hemodialysis (HD). Handgrip strength (HGS) has gained considerable attention as a marker of nutritional status and muscle function. The aim of this study was to verify the association between HGS and mortality in patients undergoing maintenance HD in Taiwan.Methods: A total of 188 stable HD patients from January to December 2009 were enrolled in the study. We used a standard handgrip dynamometer to measure the HGS. HGS was measured on enrolment at the beginning of the study. Each measurement was repeated three times for each patient, and the average value was recorded for analysis.Results: During a mean follow-up period of 47 ± 11 months, 34 of the 188 patients died. The all-cause mortality rate was 18%. Higher HGS (hazard ratio [HR] 0.891, 95% confidence interval [CI] 0.838–0.948; p < 0.001) and Kt/V (HR 0.086, 95% CI 0.018–0.421; p = 0.002) were independent factors associated with survival in HD patients. For female patients, an HGS < 17 kg had a positive predictive value (PPV) of 39% and a negative predictive value (NPV) of 96% for predicting mortality. For male patients, an HGS < 26 kg had a PPV of 29% and an NPV of 84% for predicting mortality.Conclusion: HGS provides a good marker for survival in HD patients. Our results indicate that HGS can identify male and female patients undergoing maintenance HD with an increased risk of all-cause mortality, with different cut-off values for each sex.

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“…This study showed an independent association between HGS and all-cause mortality in both men and women, even after adjustment for both CRP and albumin. Other similar studies did not correct for these two indicators at the same time (12)(13)(14)(15)(16)(17)(18). In addition, compared to other studies with non-Asian MHD patients, we analyzed the association between all-cause mortality and HGS with both categories and continuous values of HGS.…”

Section: Discussionmentioning

confidence: 99%

“…It seems to not be influenced by hydration status like other methods for lean body mass evaluation (7,(9)(10)(11). So far, several studies have reported a negative relationship between HGS and mortality risk mainly in non-Asian hemodialysis patients (12)(13)(14)(15)(16). However, some studies failed to show a statistically significant association between HGS and all-cause mortality (17, Copyright © 2019, Author(s).…”

Section: Introductionmentioning

confidence: 99%

Handgrip Strength and Mortality in Maintenance Hemodialysis Patients

Tian¹,

Zha²,

Li³

et al. 2019

Iran Red Crescent Med J

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Background: Muscle strength assessment is a convenient clinical test that has shown to correlate with the nutritional status of dialysis patients. Articles written in English to investigate the association between Handgrip Strength (HGS) and mortality in Maintenance Hemodialysis (MHD) patients are mainly from Brazil and several other non-Asian countries. Objectives: This study aimed to examine the association of HGS with all-cause mortality in Chinese MHD patients. Methods: The current multicenter observational longitudinal study enrolled MHD patients from June 2015 to June 2016. The study setting was seven dialysis centers of tertiary general hospitals in Guizhou province, China. Patients were followed up until June 2018. The ROC curves were plotted to seek the best cutoffs for HGS to predict mortality in men and women. Survival analysis was done using the Kaplan-Meier survival curve and the Cox proportional hazard model. Results: We enrolled 857 MHD patients and followed up for 24.9 ± 10.2 months. During the follow-up, 204 (23.8%) patients died, 39 (4.6%) received renal transplantation, 18 (2.1%) switched to peritoneal dialysis, and 118 (11.7%) were transferred to nonparticipating dialysis units. The cutoff value of HGS to predict all-cause mortality was 12.4 kg for women and 25 kg for men. Utilizing the cutoffs to fit the survival curve of Kaplan-Meier, the correlation of HGS with mortality was verified for both genders. After adjustment for demographic and biochemical variables, HGS remained an independent predictor of all-cause mortality. Conclusions: Handgrip strength was strongly associated with all-cause mortality in patients receiving MHD. The cutoff values to predict all-cause mortality were 12.4 kg for women and 25 kg for men. Handgrip strength may be incorporated into clinical practice for assessing functional status and predicting prognosis in MHD patients.

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Sex-age-specific handgrip strength and mortality in an incident hemodialysis cohort: The risk explained by nutrition and comorbidities

Abstract: These results provide support for the assessment of handgrip strength in all maintenance hemodialysis patients for early identification of those who may require special care to improve nutritional status and survival.

Cited by 22 publications

References 33 publications

Sex- and age-specific mild cognitive impairment is associated with low hand grip strength in an older Chinese cohort

Sex- and age-specific mild cognitive impairment is associated with low hand grip strength in an older Chinese cohort

Association of Handgrip Strength With Mortality in Hemodialysis Patients in Taiwan: A Prospective Cohort Study

Handgrip Strength and Mortality in Maintenance Hemodialysis Patients

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