Sex and ABO Blood Differences in SARS-CoV-2 Infection Susceptibility

Ergoren, Mahmut Cerkez; Akan, Gökçe; Güler, Emrah; Tuncel, Gülten; Akovalı, Damla; Evren, Emine Ünal; Evren, Hakan; Süer, Hüseyin Kaya; Şanlıdağ, Tamer

doi:10.1055/s-0043-1761202

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…Additionally, our results show an increase in seroprevalence in males compared to the female population. In numerous studies, greater susceptibility to SARS-CoV-2 of males compared to females has been observed and the male sex is considered a risk factor for both morbidity and mortality in COVID-19 [ 55 – 57 ].…”

Section: Discussionmentioning

confidence: 99%

Association between ABO blood groups and SARS-CoV-2 infection in blood donors of Puglia region

Sticchi Damiani,

Zizza,

Banchelli

et al. 2023

Ann Hematol

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This is an observational multicentric cross-sectional study aiming at assessing the association between ABO blood groups and SARS-CoV-2 seroprevalence among the blood donors in Puglia region. Data on ABO and Rh blood groups and demographic characteristics were obtained from Blood Bank Information System. All donors were screened for SARS-CoV-2 IgG antibodies. Comparison of seroprevalence among blood groups and the association between the recorded variables and seroprevalence were evaluated. A total of 35,709 donors from 22 centers were included, with a seroprevalence of 6.8%. The distribution of ABO phenotypes was blood type O (46.8%), A (34.0%), B (14.7%), and AB (4.5%). Among the 2416 donors reactive for SARS-CoV-2 IgG, the prevalent phenotype was blood type O (43.1%), followed by A (37.7%), B (14.2%), and AB (5%). The seroprevalence of phenotype A and AB was 7.5%, followed by B (6.5%) and O (6.2%). According to the adjusted analysis, there was an increase in seroprevalence in groups A and AB, compared to group O, and an increase in males compared to females. A possible effect modification was observed after stratifying for sex (p = 0.0515). A significantly lower prevalence of blood type O was found compared to A and AB, whereas no association was observed between Rh factor and seroprevalence. We hypothesized that the A antigen present in blood type A and AB can play a role in the binding of SARS-CoV-2 to ACE2 receptors, resulting in an increased risk of infection. Furthermore, natural anti-A/anti-B antibodies produced in group O could block viral adhesion to cells and explain a lower risk of infection.

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Section: Discussionmentioning

confidence: 99%

Association between ABO blood groups and SARS-CoV-2 infection in blood donors of Puglia region

Sticchi Damiani,

Zizza,

Banchelli

et al. 2023

Ann Hematol

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“…These antigens produce certain antibodies to help fight off a pathogen (Svensson et al, 2013). COVID-19 SARS coronavirus (SARS-CoV), anti-A antibodies helped to inhibit the virus; that could be the same mechanism with SARS-CoV-2, helping blood group O individuals to keep out the virus (Ergoren et al, 2023;Guillon et al, 2008;Cheng et al, 2005).…”

Section: Blood Typementioning

confidence: 99%

COVID-19 prevention and health promotion for the whole community

Mohammed,

Umar

2023

J. Public Health Dis.

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As our understanding of Covid-19 has grown, numerous techniques for preventing its spread have emerged. Scholars and practitioners in public health have focused on four important Covid-19 prevention strategies: behavioural, technical, biomedical, and structural/community-level interventions. Recent material in these areas provides an overview of current Covid-19 preventive breakthroughs. Current COVID-19 prevention models, which build on traditional techniques, use intimate partners, families, social media, emerging technology, prescription therapy, immunization, and regulatory changes to influence change. Despite significant success, more action is required to meet the national goal of stopping the COVID-19 epidemic. Government and non-governmental organizations are uniquely positioned to promote prevention science in collaboration with cross-disciplinary professionals from other domains.

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“…Glycoconjugate structures on RBCs serve various functions [ 7 ], including serving as receptors for bacteria and parasites [ 8 , 9 ], foreign ligands, viruses, transporters, channels, structural proteins, adhesion molecules, enzymes, and structural proteins. ABO blood groups are statistically or physiologically associated with a variety of non-infectious diseases – such as acute kidney injury (AKI) [ 10 ], acute respiratory distress syndrome (ARDS) [ 11 ], myocardial disease [ 12 ], pancreatic cancer [ 13 ], embolism [ 14 ] – and infectious diseases [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

ABO blood groups and nosocomial infection

Zhong¹,

Wang²,

Xiao³

et al. 2023

Epidemiol. Infect.

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Nosocomial infection (NI) harms patients' health. Timely identifying the high-risk groups of NIs plays a vital role in preventing and control of NIs. Therefore, it is crucial to investigate whether the ABO blood group is a risk factor for NI to identify and protect high-risk populations. In this study, the patients of NI and non-infection from January 2016 to July 2022 were matched by the propensity score matching (PSM) method and analysed stratified by NI pathogens and NI sites. Finally, a logistic regression model was used to analyse the matched datasets. The study found that: Patients with the B&AB blood group were susceptible to Escherichia coli (OR=1.783, P=0.039), patients with the A blood group were susceptible to Staphylococcus aureus (OR=2.539, P=0.019), and Pseudomonas aeruginosa (OR=5.724, P=0.003). Patients with the A&AB blood group were susceptible to Pseudomonas aeruginosa (OR=4.061, P=0.008). Patients with the AB blood group were vulnerable to urinary tract infection (OR=13.672, P=0.019), patients with the B blood group were susceptible to skin and soft tissue infection (OR=2.418, P=0.016), and patients with the B&AB blood group were vulnerable to deep incision infection (OR=4.243, P=0.043). Summarily, The patient's blood group is a susceptibility factor for common NI pathogens and NI sites, which is vital for identifying high-risk groups for NIs and developing targeted prevention and control measures for NIs.

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Sex and ABO Blood Differences in SARS-CoV-2 Infection Susceptibility

Cited by 3 publications

References 30 publications

Association between ABO blood groups and SARS-CoV-2 infection in blood donors of Puglia region

Association between ABO blood groups and SARS-CoV-2 infection in blood donors of Puglia region

COVID-19 prevention and health promotion for the whole community

ABO blood groups and nosocomial infection

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