Sex- and Age-Adjusted Population Analysis of Prevalence Estimates for Hidradenitis Suppurativa in the United States

Garg, Amit; Kirby, Joslyn S.; Lavian, Jonathan; Lin, Gloria; Strunk, Andrew

doi:10.1001/jamadermatol.2017.0201

Cited by 304 publications

(316 citation statements)

References 19 publications

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“…Previous studies revealed a female preponderance for HS . In 2017, the large population‐based study of 47 690 HS patients in the USA showed that the incidence of HS was twice as high among women than men . In our study, there was no significant difference of the sex ratio in the HS patients, with an overall female : male ratio of 1.06:1.0.…”

Section: Discussioncontrasting

confidence: 48%

Increased risk of cardiovascular comorbidities in hidradenitis suppurativa: A nationwide, population‐based, cohort study in Taiwan

Hung

Chiang

Chung

et al. 2019

The Journal of Dermatology

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Hidradenitis suppurativa (HS) has been reported to be associated with metabolic syndrome and coronary artery disease (CAD). Nevertheless, a nationwide study of this relationship in the Asian population has not been conducted. The aim of the present study was to clarify the cardiovascular disease risk factors, and the occurrence of CAD and cerebral infarction among patients with HS by using a nationwide database in Taiwan. We obtained data from the National Health Insurance Research Database of Taiwan. After adjusting for confounding factors, we used Cox proportional hazards analysis to reveal the risk of incident hypertension (HTN), diabetes mellitus (DM), dyslipidemia, CAD and cerebral infarction in HS patients. We identified 478 patients with newly diagnosed HS and 1912 patients in the control cohort during the 10‐year follow‐up period. Compared with the controls, HS patients had a higher risk of dyslipidemia (adjusted hazard ratio [aHR], 3.858; 95% confidence interval [CI], 2.785–5.346; P < 0.001), HTN (aHR, 1.910; 95% CI, 1.463–2.493; P < 0.001), DM (aHR, 1.709; 95% CI, 1.127–2.591; P = 0.012). Regarding comorbidities, our results also revealed a higher risk of CAD in HS patients (aHR, 2.722; 95% CI, 1.628–4.553; P < 0.001), but not cerebral infarction (aHR, 0.514; 95% CI, 0.119–2.231; P = 0.375). Our results indicate that there is a higher risk of dyslipidemia, HTN, DM and CAD in HS patients.

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Section: Discussioncontrasting

confidence: 48%

Increased risk of cardiovascular comorbidities in hidradenitis suppurativa: A nationwide, population‐based, cohort study in Taiwan

Hung

Chiang

Chung

et al. 2019

The Journal of Dermatology

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“…Also, most experts concur that the maximum duration of the active form of HS in a given patient is about 20 years [6]. With regard to the estimated prevalence of the disease in European countries and in the United States, available data differ by up to four orders of magnitude, ranging from 0.00033% to 4.1% [7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Situation In the Usa And Europementioning

confidence: 99%

“…Więk-szość ekspertów jest również zgodna, że czas trwania czynnej postaci HS wynosi u danego pacjenta maksymalnie ok. 20 lat [6]. Dane dotyczące częstości wystę-powania choroby w krajach europejskich i USA różnią się nawet o 4 rzędy wielkości i mieszczą się w przedziale od 0,00033% do 4,1% [7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Sytuacja W Usa I Europieunclassified

“…A recently published retrospective population-based study, also relying on a medical register of patients comprising 27 integrated healthcare organizations in the USA, was aimed at determining the prevalence of HS in a population of over 48 million patients [7]. The prevalence of HS in the study was estimated at 0.01%.…”

Section: Sytuacja W Usa I Europiementioning

confidence: 99%

“…W ostatnio opublikowanym badaniu populacyjnym o charakterze retrospektywnym, opartym na medycznym rejestrze pacjentów obejmującym 27 zintegrowanych organizacji ochrony zdrowia w USA, oceniono częstość występowania HS u ponad 48 milionów pacjentów [7]. W przypadku tej pracy częstość występowania HS wynosiła 0,01%.…”

Section: Sytuacja W Usa I Europieunclassified

See 2 more Smart Citations

Epidemiology of hidradenitis suppurativa in Poland in relation to international data

Matusiak¹,

Kaszuba²,

Krasowska³

et al. 2017

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Overall and Subgroup Prevalence of Crohn Disease Among Patients With Hidradenitis Suppurativa

2018

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idradenitis suppurativa (HS) is a debilitating disease of the pilosebaceous unit that results in painful nodules and abscesses commonly involving axillary, inguinal, perineal, and inframammary regions. The inherent unpredictability of the disease, both with respect to course and response to treatment, poses substantial challenges for patients. 1 Hidradenitis suppurativa shares several clinical features with Crohn disease (CD), and previous observational studies have suggested a link between the 2 conditions. However prevalence estimates for CD among patients with HS are highly variable. 2-7 Moreover, population-based prevalence estimates and strength of association analyses from outside of Europe are lacking. We sought to evaluate the prevalence of CD among patients with HS in the United States. Methods Patient Population This was a cross-sectional analysis using a multiple health system data analytics and research platform (Explorys) developed by IBM Corporation, Watson Health. 8 Clinical information from electronic medical records, laboratories, practice IMPORTANCE Limited evidence supports a link between hidradenitis suppurativa (HS) and Crohn disease (CD), and this relationship has not been established in the United States. OBJECTIVE To evaluate the prevalence of CD among patients with HS in the United States and to determine the strength of association between the 2 conditions. DESIGN, SETTING, AND PARTICIPANTS Cross-sectional analysis of data from 51 340 patients with HS identified using electronic health records data in the Explorys multiple health system data analytics and research platform, which includes data from more than 50 million unique patients across all US census regions. MAIN OUTCOMES AND MEASURES Primary outcome was diagnosis of CD. RESULTS Of the 18 455 660 total population considered, 51 340 had HS (35 000 women). Of these patients with HS, 29 010 (56.5%) were aged 18 to 44 years; 17 580 (34,2%), 45 to 64 years; and 4750 (9.3%), 65 years or older. Prevalence of CD among patients with HS was 2.0% (1025/51 340), compared with 0.6% (113 360/18 404 260) among those without HS (P < .001). Prevalence of CD was greatest among patients with HS who were white (2.3%), aged 45 to 64 years (2.4%), nonobese (2.8%), and tobacco smokers (2.3%). In univariable and multivariable analyses, patients with HS had 3.29 (95% CI, 3.09-3.50) and 3.05 (95% CI, 2.87-3.25) times the odds of having CD, respectively, compared with patients without HS. Crohn disease was associated with HS across all patient subgroups. The association was strongest for men (OR, 3.61; 95% CI, 3.24-4.03), patients aged 45 to 64 years (OR, 3.49; 95% CI, 3.16-3.85), nonobese patients (OR, 4.09; 95% CI, 3.69-4.54), and nonsmokers (OR, 3.44; 95% CI, 3.10-3.82). CONCLUSIONS AND RELEVANCE These data suggest that patients with HS are at risk for CD. Gastrointestinal symptoms or signs suggestive of CD warrant additional evaluation by a gastroenterologist.

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Sex- and Age-Adjusted Population Analysis of Prevalence Estimates for Hidradenitis Suppurativa in the United States

Cited by 304 publications

References 19 publications

Increased risk of cardiovascular comorbidities in hidradenitis suppurativa: A nationwide, population‐based, cohort study in Taiwan

Increased risk of cardiovascular comorbidities in hidradenitis suppurativa: A nationwide, population‐based, cohort study in Taiwan

Epidemiology of hidradenitis suppurativa in Poland in relation to international data

Overall and Subgroup Prevalence of Crohn Disease Among Patients With Hidradenitis Suppurativa

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