Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients

Nøland, Sara Tellefsen; Badian, Reza A.; Utheim, Tor Paaske; Utheim, Øygunn Aass; Stojanović, Aleksandar; Tashbayev, Behzod; Ræder, Sten; Dartt, Darlene A.; Chen, Xiangjun

doi:10.1016/j.jtos.2020.11.009

Cited by 21 publications

(13 citation statements)

References 47 publications

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“…User profile showed that women were the main searchers, which was consistent with previous research that women are at greater risk of DED ( 36 ). However, several studies reported the age was the important risk of DED, while we found the teenagers search more about DED than middle-aged and older in this study ( 37 – 39 ). This may be due to differences in the study population, with adolescents likely to be more adept at accessing information from the internet.…”

Section: Discussioncontrasting

confidence: 47%

Utilizing Baidu Index to Investigate Seasonality, Spatial Distribution and Public Attention of Dry Eye Diseases in Chinese Mainland

Zeng

Zhang

et al. 2022

Front. Public Health

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PurposeTo explore the characteristics of spatial-temporal prevalence and public attention of dry eye diseases (DED) through Baidu Index (BI) based on infodemiology method.MethodsThe data about BI of DED were collected from Baidu search engine using “Dry eye diseases” as keyword. The spatial and temporal distribution of DED were analyzed through timeseries data decomposition as well as spatial autocorrelation and hotspot detection of BI about DED. The most popular related words and demographic characteristics were recorded to determine the public attention of DED.ResultsThe trends of BI about DED in Chinese mainland had gradually increased over time with a rapid increase from 2012 to 2014 and in 2018. The results of timeseries decomposition indicated that there was seasonality in the distribution of BI about DED with the peak in winter, especially in northern regions. The geographic distribution demonstrated the search activities of DED was highest in the east of Chinese mainland while lowest in the west. The vast majority of people searching for DED were teenagers (20–29 years), with a predominance of females. Glaucoma, keratitis and conjunctivitis were the diseases most often confused with DED, and the artificial tears were the most common treatment for DED in Chinese mainland according to the BI about DED.ConclusionsThe analysis revealed the seasonality, geographic hotspots and public concern of DED through BI in Chinese mainland, which provided new insights into the epidemiology of DED.

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Section: Discussioncontrasting

confidence: 47%

Utilizing Baidu Index to Investigate Seasonality, Spatial Distribution and Public Attention of Dry Eye Diseases in Chinese Mainland

Zeng

Zhang

et al. 2022

Front. Public Health

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“…According to a study by Tellefsen Nøland et al, women had significant increased osmolarity, shorter tear break-up time (TBUT), decreased meibum quality, reduced meibum expressibility and decreased corneal sensitivity than men. 35 Increased age was associated with significantly worse Ocular Surface Disease Index (OSDI) score, shorter TBUT, lower Schirmer I test score and Open access reduced meibum expressibility. Postmenopausal women were found to have higher scores related to ocular symptoms, vision-related functions and environmental triggers than perimenopausal women, and OSDI score increased with age.…”

Section: Discussionmentioning

confidence: 98%

Economic burden and loss of quality of life from dry eye disease in Canada

Chan

Ziai

Myageri³

et al. 2021

BMJ Open Ophth

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ObjectiveTo describe the direct and indirect cost estimates of dry eye disease (DED), stratified by disease severity, and the impact of DED on quality of life (QoL) in Canadian patients.Methods and analysisA prospective, multicentre, observational, cross-sectional study was conducted at six sites across Canada. Eligible patients completed a 20 min survey on demography, general health, disease severity, QoL and direct (resource utilisation and out-of-pocket expenses for the past 3–24 months) and indirect costs (absenteeism and presenteeism based on Work Productivity and Activity Impairment questionnaire responses). Subgroup analyses were performed according to DED severity and presence of Sjögren’s syndrome.ResultsResponses from 146 of 151 participants were included in the analysis. DED was rated as moderate or severe by 19.2% and 69.2% of patients, respectively. Total mean annual costs of DED were $C24 331 (Canadian dollars) per patient and increased with patient-reported disease severity. Mean (standard deviation [SD]) indirect costs for mild, moderate and severe disease were $C5961 ($C6275), $C16 525 ($C11 607), and $C25 485 ($C22,879), respectively. Mean (SD) direct costs were $C958 ($C1216), $C1303 ($C1574) and $C2766 ($C7161), respectively. QoL scores were lowest in patients with Sjögren’s syndrome (8.2% of cohort) and those with severe DED.ConclusionThis study provides important insights into the negative impact of DED in a Canadian setting. Severe DED was associated with higher direct and indirect costs and lower QoL compared with those with mild or moderate disease. Increased costs and poorer QoL were also evident for patients with DED plus Sjögren’s syndrome versus DED alone.

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“…Our data demonstrate that FUT1 and its fucosylated products are expressed in the eyelid and MG, and FUT1 deficiency impedes the eyelid MG development and function in mice. Since the disruption of MGs in Fut1 KO mice did not progress until 44 weeks of age, it is likely that FUT1 deficiency affects the development of MG but does not contribute to age-dependent MG dropout and meibum loss, common findings in age-related DED in old patients [ 21 , 22 , 23 ]. Given, however, that mice between 34 and 44 weeks of age are considered middle-aged, not old-aged, from an aging perspective, it would be necessary to confirm these results in older mice.…”

Section: Discussionmentioning

confidence: 99%

The Eyelid Meibomian Gland Deficiency in Fucosyltransferase 1 Knockout Mice

Yoon

Ryu

et al. 2022

IJMS

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To investigate the effect of fucosyltransferase (FUT) 1-mediated fucosylation on meibomian glands (MG), we first confirmed that FUT1 and its fucosylated products were expressed in the eyelid, conjunctiva and skin in wild-type (WT) mice, whereas their mRNA and protein levels were downregulated in Fut1 knock-out (KO) mice. We then evaluated age-dependent changes in the total and acinar areas of MG, meibocyte differentiation, lipid synthesis, and eyelid inflammation and oxidative stress in Fut1 KO and WT mice. Results show that both the total and acinar areas of MG were smaller in Fut1 KO mice than in WT mice in all evaluated age groups. Meibocyte differentiation, lipid-producing capacities and the enzyme levels responsible for lipid synthesis were reduced in Fut1 KO mice, compared to WT controls. The levels of pro-inflammatory cytokines and oxidative-stress-related markers were elevated in the eyelids and MG of FUT1 KO mice. These findings demonstrate the physiologic function of FUT1-mediated fucosylation in MG development and function, and indicate its potential role in ocular surface homeostasis.

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Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients

Cited by 21 publications

References 47 publications

Utilizing Baidu Index to Investigate Seasonality, Spatial Distribution and Public Attention of Dry Eye Diseases in Chinese Mainland

Utilizing Baidu Index to Investigate Seasonality, Spatial Distribution and Public Attention of Dry Eye Diseases in Chinese Mainland

Economic burden and loss of quality of life from dry eye disease in Canada

The Eyelid Meibomian Gland Deficiency in Fucosyltransferase 1 Knockout Mice

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