Sex and age-related differences in cerebral blood flow investigated using pseudo-continuous arterial spin labeling magnetic resonance imaging

Alisch, Joseph S R; Khattar, Nikkita; Kim, Richard W.; Cortina, Luis E.; Rejimon, Abinand C.; Qian, Wenshu; Ferrucci, Luigi; Resnick, Susan M.; Spencer, Richard G.; Bouhrara, Mustapha

doi:10.18632/aging.202673

Cited by 42 publications

(57 citation statements)

References 69 publications

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“…Alicioglu et al (2017) observed that women experience a steeper increase in MD after the age of 61 as compared to men. Further, several studies have shown that women exhibit higher CBF as compared to men (Devous et al, 1986;Rodriguez et al, 1988;Podreka et al, 1989;Gur and Gur, 1990;Esposito et al, 1996;Parkes et al, 2004;Liu et al, 2012Liu et al, , 2016Alisch et al, 2021). Sex differences in CP microstructure and function would be expected.…”

Section: Discussionmentioning

confidence: 95%

“…Several quantitative MRI techniques have been used to evaluate cerebral tissue microstructure in-vivo with aging and neuropathology (Grieve et al, 2007;Hasan et al, 2010;Alisch et al, 2021). Longitudinal and transverse relaxation times (T 1 and T 2 ) depend on water mobility as well as macromolecular tissue composition including iron content; therefore, changes in T 1 or T 2 are directly associated with cerebral microstructural tissue changes (Deoni, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Age-Related Differences in the Human Choroid Plexus Volume, Microstructural Integrity, and Blood Perfusion Using Multiparameter Magnetic Resonance Imaging

Alisch

Kiely

Triebswetter

et al. 2021

Front. Aging Neurosci.

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The choroid plexus (CP) is an important cerebral structure involved in cerebrospinal fluid production and transport of solutes into the brain. Recent studies have uncovered the involvement of the CP in neurological disorders such as Alzheimer’s disease and multiple sclerosis. However, our understanding of human age-related microstructural and functional changes in the CP with aging and neuropathology is limited. In this cross-sectional study, we investigated age and sex differences in the CP structure and function using advanced quantitative magnetic resonance imaging methodology in a large cohort (n = 155) of cognitively unimpaired individuals over a wide age range between 21 and 94 years. Our analysis included volumetric measurements, relaxometry measures (T1 and T2), diffusion tensor imaging (DTI) measures of fractional anisotropy (FA) and mean diffusivity (MD), as well as measures of cerebral blood flow (CBF). Our results revealed that CP volume was increasing with advancing age. We conjecture that this novel observation is likely attributed to alterations in the CP microstructure or function as well as to ventriculomegaly. Indeed, we also found that CBF was lower with advanced age, while, consistent with previous studies, T1, T2 and MD were higher, and FA was lower with advanced age. We attribute these functional and microstructural differences to a deteriorated CP structural integrity with aging. Furthermore, our relaxometry and DTI measures were found to be associated with differences in blood perfusion revealing lower microstructural integrity with lower CBF. Finally, in agreement with literature, sex-related differences in MD and CBF were statistically significant. This work lays the foundation for ongoing investigation of the involvement of CP in neurodegeneration.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Characterization of Age-Related Differences in the Human Choroid Plexus Volume, Microstructural Integrity, and Blood Perfusion Using Multiparameter Magnetic Resonance Imaging

Alisch

Kiely

Triebswetter

et al. 2021

Front. Aging Neurosci.

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“…Neurocognitive deficits have been attributed partly to cerebral hypoperfusion. Alisch et al (2021) found that CBF differs between men and women. Several human studies to date have demonstrated sex differences in CBF in multifocal brain regions and cognitive outcome in mTBI patients (Stephens et al, 2018;Bai et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Arterial-spin labeling (ASL), as a promising MRI approach, could provide reproducible and reliable quantitative measurements of cerebral perfusion non-invasively (Bai et al, 2019;Alisch et al, 2021). This technique has been implemented to detect CBF in mTBI individuals (Bai et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Cerebral blood flow network differences correlated with cognitive impairment in mild traumatic brain injury

Deng

Liu

et al. 2022

Front. Neurosci.

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PurposeTo examine whether the cerebral blood flow (CBF) and CBF connectivity differences are sex-specific and whether these differences are correlated with cognitive impairment in mTBI.MethodsResting-state perfusion magnetic resonance imaging was performed in 40 patients with acute mTBI and 40 healthy controls by using pseudocontinuous arterial spin labeling within 14 days following injury. The differences in normalized CBF were first compared and CBF connectivity of the brain regions with significant CBF differences were compared next. The association between the normalized CBF and CBF connectivity differences and cognitive function were further investigated.ResultsMen patients had lower normalized CBF in the frontal gyrus, temporal gyrus and hippocampus and decreased negative CBF connectivity between brain regions including the hippocampus, temporal gyrus, postcentral gyrus and lenticular nucleus, putamen, compared with men controls. Women patients had lower normalized CBF in the frontal gyrus, however had higher normalized CBF in the temporal gyrus and hippocampus, compared with women controls. Additionally, women patients showed increased positive CBF connectivity between the seed region of interest (ROI) of the right inferior temporal gyrus and temporal gyrus and frontal gyrus, and had increased positive CBF connectivity between the seed ROI of the right hippocampus and the temporal gyrus. Furthermore, men patients had higher CBF in the right middle temporal gyrus and left precentral gyrus than women patients.ConclusionThis study provides evidence of sex differences in both decreased and increased CBF and CBF connectivity and association with cognitive outcome in the acute stage after mTBI.

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“…The intricate etiology and pathogenesis of CSVD has been extensively studied in recent study. While age is the most robust determinant of severity and progression of WMHs ( 12 , 13 ), the complex interaction between hereditary and environmental exposures to hypertension, diabetes mellitus, smoking, and drinking also plays a significant role ( 14 ). The underlying mechanisms linked to WMHs include inflammation/oxidative stress ( 15 ), ischemia/hypoperfusion ( 2 ), barrier/endothelial dysfunction ( 16 ), glymphatic system dysfunction ( 17 ), and genetic factors.…”

Section: Introductionmentioning

confidence: 99%

Contribution of Inflammation and Hypoperfusion to White Matter Hyperintensities-Related Cognitive Impairment

et al. 2022

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White matter hyperintensities (WMHs) of presumed vascular origin are one of the most important neuroimaging markers of cerebral small vessel disease (CSVD), which are closely associated with cognitive impairment. The aim of this study was to elucidate the pathogenesis of WMHs from the perspective of inflammation and hypoperfusion mechanisms. A total of 65 patients with WMHs and 65 healthy controls were enrolled in this study. Inflammatory markers measurements [hypersensitive C-reactive protein (hsCRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2)], cognitive evaluation, and pseudocontinuous arterial spin labeling (PCASL) MRI scanning were performed in all the subjects. The multivariate logistic regression analysis showed that Lp-PLA2 was an independent risk factor for WMHs. Cerebral blood flow (CBF) in the whole brain, gray matter (GM), white matter (WM), left orbital medial frontal gyrus [MFG.L (orbital part)], left middle temporal gyrus (MTG.L), and right thalamus (Tha.R) in the patients was lower than those in the controls and CBF in the left triangular inferior frontal gyrus [IFG.L (triangular part)] was higher in the patients than in the controls. There was a significant correlation between Lp-PLA2 levels and CBF in the whole brain (R = −0.417, p < 0.001) and GM (R = −0.278, p = 0.025), but not in the WM in the patients. Moreover, CBF in the MFG.L (orbital part) and the Tha.R was, respectively, negatively associated with the trail making test (TMT) and the Stroop color word test (SCWT), suggesting the higher CBF, the better executive function. The CBF in the IFG.L (triangular part) was negatively correlated with attention scores in the Cambridge Cognitive Examination-Chinese Version (CAMCOG-C) subitems (R = −0.288, p = 0.020). Our results revealed the vascular inflammation roles in WMHs, which may through the regulation of CBF in the whole brain and GM. Additionally, CBF changes in different brain regions may imply a potential role in the modulation of cognitive function in different domains.

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Sex and age-related differences in cerebral blood flow investigated using pseudo-continuous arterial spin labeling magnetic resonance imaging

Cited by 42 publications

References 69 publications

Characterization of Age-Related Differences in the Human Choroid Plexus Volume, Microstructural Integrity, and Blood Perfusion Using Multiparameter Magnetic Resonance Imaging

Characterization of Age-Related Differences in the Human Choroid Plexus Volume, Microstructural Integrity, and Blood Perfusion Using Multiparameter Magnetic Resonance Imaging

Cerebral blood flow network differences correlated with cognitive impairment in mild traumatic brain injury

Contribution of Inflammation and Hypoperfusion to White Matter Hyperintensities-Related Cognitive Impairment

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