Sex and estrous cycle dependent changes in locomotor activity, anxiety and memory performance in aged mice after exposure of light at night

Datta, Siddhartha A.K.; Samanta, Diptaman; Tiwary, Basant K.; Chaudhuri, Alok Ghosh; Chakrabarti, N.B.

doi:10.1016/j.bbr.2019.03.015

Cited by 21 publications

(11 citation statements)

References 89 publications

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“…It was necessary, because previous experimental studies have shown that sex hormones affect the behavioral outcomes of rodents across life (e.g. locomotor activity, anxiety, cognitive function) (Mitra et al 2016, Onaolapo et al 2016, Domonkos et al 2017, Domonkos et al 2018, Jardi et al 2018 and, in females, behavioral changes occur according to the variation in phases of the estrous cycle (Datta et al 2016, Datta et al 2019. Besides, we have resigned to record more animals simultaneously to prevent the effect of the presence of another animal on the behavioral outcomes.…”

Section: Discussionmentioning

confidence: 99%

Sex-Related Differences in Locomotion and Climbing of C57Bl/6NTac Mice in a Novel Environment

et al. 2019

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Laboratory mice in standard laboratory cages, besides horizontal and vertical locomotor activity, spontaneously display cage-bar related activities such as cage-grid climbing. Although, grid-climbing activity is one of the major components of spontaneous home-cage behavior of mice, its exact role is not fully understood. This study aimed to describe the sex-differences in coping with novelty and in spontaneous behavior of laboratory mice concerning the cage-climbing activity in an observer-independent open field test. Adult mice of both sexes (C57Bl/6NTac) underwent behavioral testing in LABORAS system. Female mice travelled significantly longer distance (by 30 %, p<0.05) and showed higher grid-climbing activity (by 50 %, p<0.05) than males. Based on our results, the grid-climbing is a sex-dependent activity of mice, however, its exact role remains to be elucidated.

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Section: Discussionmentioning

confidence: 99%

Sex-Related Differences in Locomotion and Climbing of C57Bl/6NTac Mice in a Novel Environment

et al. 2019

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“…We also investigated if there is a daytime commonly used for OF tests in pigs. Rodents are nocturnal animals and most of the OF tests were performed during their inactive phase [97]. Most domestic animals are diurnal [25].…”

Section: Discussionmentioning

confidence: 99%

The Open Field test as a tool for behavior analysis in pigs - is a standardization of setup necessary? A systematic review

Schulz

Zieglowski

Kopaczka

et al. 2021

Preprint

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Background: The Open Field test is a common tool to measure anxiety and behavioral changes in rodents. However, scientific findings of rodent experiments may not translate adequately to humans and it has been shown that larger animal models might perform better in that regard. As a result, the number of published studies involving the Open Field test in domestic pig models is increasing. Objective: The aim of our review was to investigate the Open Field set-ups in published studies as well as similarity between performance and parameters published. Results: Following the PRISMA guidelines for reviews we selected 69 studies for data extraction in this systematic review. We were able to determine specific set-up conditions such as size, duration and daytime for most of the included studies and found a high variability within these test specifiers. Conclusion: Results indicate a non-uniform performance of set-up including size, timing, parameters and additional combined tests such as the novel object test. We would like to point out the need for standardization of Open Field test for pigs in order to improve result, comparability and reduce inconsistencies.

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“…The green light was reported to aggravate high-fat diet-induced obesity and metabolic disorders in male mice (Zhang et al, 2019). Light-at-night (LAN) altered locomotor activities, anxiety and memory for recognition in aged rats in a sex and hormonedependent manner (Datta et al, 2019). Exposure duration is also a determinant factor of the light biological effect.…”

Section: Discussionmentioning

confidence: 99%

“…Constant lighting is the extremity of prolonged light exposure. Constant or prolonged light exposure was reported to have a series of actions, such as brain development, psychosocial and emotional disorders, reproductive failure, biliary hyperplasia and liver fibrosis, increased oxidative stress and loss of circadian rhythms in locomotor activity, energy metabolism and insulin sensitivity (Tapia-Osorio et al, 2013;Alves-Simoes et al, 2016;Benedetto and Contin, 2019;Chen et al, 2019;Datta et al, 2019;Fobert et al, 2019;Haraguchi et al, 2019). The biological action of light on cardiovascular system is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats

Jing¹,

Wu²,

et al. 2020

Front. Neurosci.

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It has been documented that constant light exposure exerts complicated cardiovascular effects. However, a mounting collection of conflicting results did not make it any easier for researchers and physicians to consider the role of light on cardiovascular function. This study was designed to investigate how constant light exposure (24 h light/day) influences the cardiac function in normal and heart-failure (HF) rats. In normal rats, two groups of SD rats were accustomed in 12 h light/12 h dark (LD) or 24 h light (constant light, CL) for 4 weeks. In HF rats which was induced by myocardial infarction (MI) was let recover in LD for 4 weeks. Interestingly, compared with rats in LD environment (ejection fraction, EF%: 93.64 ± 2.02 in LD, 14.62 ± 1.53 in HF-LD), constant light (2 weeks) weakened the cardiac function in normal and HF rats (EF%: 79.42 ± 2.91 in CL, 11.50 ± 1.08 in HF-CL). The levels of renal sympathetic nerve activity and c-fos expression in the rostral ventrolateral medulla (RVLM), a key region controlling sympathetic outflow, were significantly increased in normal and HF rats after

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Sex and estrous cycle dependent changes in locomotor activity, anxiety and memory performance in aged mice after exposure of light at night

Cited by 21 publications

References 89 publications

Sex-Related Differences in Locomotion and Climbing of C57Bl/6NTac Mice in a Novel Environment

Sex-Related Differences in Locomotion and Climbing of C57Bl/6NTac Mice in a Novel Environment

The Open Field test as a tool for behavior analysis in pigs - is a standardization of setup necessary? A systematic review

Constant Light Exerted Detrimental Cardiovascular Effects Through Sympathetic Hyperactivity in Normal and Heart Failure Rats

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