Sex and gender perspectives in colorectal cancer

Baraibar, Iosune; Ros, Javier; Saoudi, Nadia; Salvà, Francesc; Garcia, Ana Rita; Castells, Marta R; Tabernero, Josep; Élez, Elena

doi:10.1016/j.esmoop.2023.101204

Cited by 48 publications

(24 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While it is widely appreciated that biological sex can greatly affect cancer biology and treatment outcomes [ 30 , 31 ], proteomic analyses that describe such contributions, especially in CRLM, are rarely reported. In this study, we investigated if biological sex was associated with differences in the spatial proteome of CRLM.…”

Section: Discussionmentioning

confidence: 99%

Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases.

Li,

Briggs,

Lee

et al. 2024

Clin Exp Med

View full text Add to dashboard Cite

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. CRC liver metastases (CRLM) are often resistant to conventional treatments, with high rates of recurrence. Therefore, it is crucial to identify biomarkers for CRLM patients that predict cancer progression. This study utilised matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to spatially map the CRLM tumour proteome. CRLM tissue microarrays (TMAs) of 84 patients were analysed using tryptic peptide MALDI-MSI to spatially monitor peptide abundances across CRLM tissues. Abundance of peptides was compared between tumour vs stroma, male vs female and across three groups of patients based on overall survival (0-3 years, 4-6 years, and 7+ years). Peptides were then characterised and matched using LC-MS/MS. A total of 471 potential peptides were identified by MALDI-MSI. Our results show that two unidentified m/z values (1589.876 and 1092.727) had significantly higher intensities in tumours compared to stroma. Ten m/z values were identified to have correlation with biological sex. Survival analysis identified three peptides (Histone H4, Haemoglobin subunit alpha, and Inosine-5’-monophosphate dehydrogenase 2) and two unidentified m/z values (1305.840 and 1661.060) that were significantly higher in patients with shorter survival (0-3 years relative to 4-6 years and 7+ years). This is the first study using MALDI-MSI, combined with LC-MS/MS, on a large cohort of CRLM patients to identify the spatial proteome in this malignancy. Further, we identify several protein candidates that may be suitable for drug targeting or for future prognostic biomarker development.

show abstract

Section: Discussionmentioning

confidence: 99%

Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases.

Li,

Briggs,

Lee

et al. 2024

Clin Exp Med

View full text Add to dashboard Cite

show abstract

“…Since 1990, the increase ASIR and ASMR has been more pronounced in males compared to females. CRC is more prevalent in males, with studies revealing that colorectal adenomas are more common in males, while females exhibit a higher occurrence of right-sided proximal CRC, and males tend to have left-sided distal colon cancer [19][20][21]. In comparison to females, the association between obesity and overall CRC risk is more significant in males.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, the frequency of STK11 mutations is higher in males, and gender dimorphism in the proteomic profile of CRC cells may contribute to biological differences between genders in these tumors [26,27]. The proportion of patients with right-sided tumors is higher in females due to the prevalence of BRAF mutation tumors [21]. Hormones may also explain the higher incidence of right-sided CRC in females.…”

Section: Discussionmentioning

confidence: 99%

Disease Burden of Colorectal Cancer in China from 1990 to 2019: Age- and Sex-Specific Time Trends and 10-Year Forecast

Zhai,

Wang

2023

Oncol Res Treat

View full text Add to dashboard Cite

Introduction: Colorectal cancer (CRC) is the third most prevalent malignant tumor worldwide and the second leading cause of cancer-related death.Aimed to report the disease burden of CRC in China from 1990 to 2019 and predict the trend of mortality burden over the next 10 years. Methods: The age-period-cohort (APC) model was implemented to analyze the trends of mortality from CRC in China from 1990 to 2019, and the autoregressive integrated moving average (ARIMA) model was used to predict the trends of CRC incidence and mortality from 2020 to 2029. Results: From 1990 to 2019, the incidence of CRC in China increased from 105,911 cases (95% uncertainty interval (UI): 93,808-119,021) to 607,900 cases (95% UI: 521,805-708,420). The age-standardized incidence rate (ASIR) increased from 12.52 per 100,000 (95% UI: 11.15-14.03) to 30.55 per 100,000 (95% UI: 26.37-35.5), with an estimated annual percentage change (EAPC) of 3.66 (95% confidence interval (CI): 3.37-3.95), showing an upward trend. The age-standardized mortality rate (ASMR) increased from 10.18 per 100,000 (95% UI: 9.03-11.37) to 13.86 per 100,000 (95% UI: 11.92-16.01), with an EAPC of 1.39 (95% CI: 1.14-1.63), also showing an upward trend. The age group with the highest incidence and mortality in 2019 was 65-69 years old for both sexes, and the age group with the highest mortality was 70-74 years old. Males had higher relative risks of incidence and mortality than females. Low-calcium diet was the risk factor for both sexes and females alone in 1990, while low-milk diet was the risk factor in 2019; however, smoking remained the risk factor for males. The ARIMA model predicted an increase in both disease and mortality burden of CRC over the next 10 years. Conclusion: The disease and mortality burden of CRC in China showed an overall upward trend from 1990 to 2019, with higher burden in males than females, and the situation remains extremely severe in the next decade.

show abstract

“…Interestingly, there are no significant prognosis difference amongst AI-recognized ARG subgroups in the female cohort ( Figure 6F ). To our knowledge, the tumoral biology of CRC is significantly different between female and males [ 28 ]. For example, significant differences in progression-free survival (PFS) are observed in the male cohort with combining treatment of capecitabine and bevacizumab, while it’s no significant difference in the female cohort [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Anoikis regulator GLI2 promotes NC cell immunity escape by TGF-β-mediated non-classic hedgehog signaling in colorectal cancer: based on artificial intelligence and big data analysis

Shanshan,

Fanfei,

Xuan

et al. 2023

Aging

View full text Add to dashboard Cite

Background: Anoikis is a speed-limited procedure to inhibit tumor metastasis during epithelial-mesenchymal transition (EMT). Previous studies have explored anoikis-related genes (ARG) in predicting prognosis and distinguishing tumoral immunity in many types of cancer. However, the role of ARGs in regulating NK cell exhaustion (NKE) and in predicting chemotherapy sensitivity is not clear. Therefore, it is necessary to work on it. Methods: Gene expression profiles and clinical features are collected from TCGA and GEO, and data analysis is performed in R4.2.0. Results: The ARGs-based no-supervised learning algorithm identifies three ARG subgroups, amongst which the prognosis is different. WCGNA and Artificial intelligence (AI) are applied to construct an NKE-related drug sensitivity stratification and prognosis identification model in digestive system cancer. Pathways association analysis screens out GLI2 is a key gene in regulating NKE by non-classic Hedgehog signaling (GLI2/TGF-β/IL6). In vitro experiments show that down-regulation of GLI2 enhances the CAPE-mediated cell toxicity and accompanies with down-regulation of PD-L1, tumor-derive IL6, and snial1 whereas the expression of cleaved caspas3, cleaved caspase4, cleaved PARP, and E-cadherin are up-regulated in colorectal cancer. Co-culture experiments show that GLI2- decreased colorectal tumor cells lead to down-regulation of TIM-3 and PD1 in NK cells, which are restored by TGF-bate active protein powder. Besides, the Elisa assay shows that GLI2-decreased colorectal tumor cells lead to up-regulation of IFN-gamma in NK cells.

show abstract

Sex and gender perspectives in colorectal cancer

Cited by 48 publications

References 97 publications

Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases.

Use of tryptic peptide MALDI mass spectrometry imaging to identify the spatial proteomic landscape of colorectal cancer liver metastases.

Disease Burden of Colorectal Cancer in China from 1990 to 2019: Age- and Sex-Specific Time Trends and 10-Year Forecast

Anoikis regulator GLI2 promotes NC cell immunity escape by TGF-β-mediated non-classic hedgehog signaling in colorectal cancer: based on artificial intelligence and big data analysis

Contact Info

Product

Resources

About