2024
DOI: 10.1101/2024.11.18.24317491
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Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction

Yuefeng Huang,
Eduardo R. Butelman,
Ahmet O. Ceceli
et al.

Abstract: ObjectiveTo study the sex and hormonal effects on cortico-striatal engagement during drug cue-reactivity and its regulation focusing on drug reappraisal.MethodsForty-nine men (age=41.96±9.71) with heroin use disorder (HUD) and 32 age-matched women (age=38.85±9.84) with HUD (n=16) or cocaine use disorder (CUD; n=16) were scanned using functional MRI, with a subgroup of women scanned twice, during the late-follicular and mid-luteal phases, to examine sex and menstrual phase differences in cortico-striatal drug c… Show more

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