2023
DOI: 10.1101/2023.02.02.526857
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Sex and interferon gamma signaling regulate microglia migration in adult mouse cortexin vivo

Abstract: Although microglia possess the unique ability to migrate, whether mobility is evident in all microglia, is sex dependent, and what molecular mechanisms drive this, is poorly understood in the adult brain. Using longitudinal in vivo imaging of sparsely labelled microglia, we find a relatively small population of microglia are mobile under normal conditions. Following injury (microbleed), the population of mobile microglia increased in a sex-dependent manner, with male microglia migrating significantly greater d… Show more

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