Sex and modulatory menstrual cycle effects on sleep related memory consolidation

Genzel, Lisa; Kiefer, T; Renner, Lisa; Wehrle, R.; Kluge, Michael; Grözinger, Michael; Steiger, Axel; Dresler, Martin

doi:10.1016/j.psyneuen.2011.11.006

Cited by 111 publications

(121 citation statements)

References 67 publications

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“…non-perimenses). Regarding Stage 2 sleep features (i.e., spindles, slow oscillations and spindle/SO events), unlike prior reports (Ishizuka et al, 1994;Genzel et al, 2012), we did not find differences in spindle events based on sex and hormone phase, which may be due in part to the use of different menstrual cycle categories in this study. Additionally, we did not observe differences in SO events or spindle/SO coincidences between men and women, and no differences due to menstrual phase.…”

Section: Discussioncontrasting

confidence: 99%

“…One prior study examined sleep-dependent learning in a non-declarative visual learning task in men and women (McDevitt et al, 2014), without considering menstrual cycle effects in the female subjects. In addition, the only two published studies that investigated the interaction between sex steroid levels and sleep-related memory consolidation in women, only focused on spindle activity (Genzel et al, 2012;Genzel et al, 2015). Unlike the present study, prior results report increased spindles in females compared with males (Huupponen et al, 2002, Carrier et al, 2001.…”

Section: Discussioncontrasting

confidence: 82%

“…third week of the cycle) and men performed better compared to women during menses, on a declarative and procedural motor memory task after a nap. Estrogen correlated with declarative and progesterone correlated with motor performance improvement (Genzel et al, 2012). In addition, sleep spindles were related to memory enhancement, but only for women during their luteal phase and men, suggesting that sex hormones and phase in menstrual cycle in women may mediate the relation between sleep features and sleep-dependent memory consolidation.…”

Section: Introductionmentioning

confidence: 90%

“…These findings suggest that female cognition may be dynamically modulated by sex hormone levels. Although sex hormones could directly impact cognitive processing, it is also possible that hormones interact with other brain functions that mediate the relation between sex hormones and cognition, especially the interaction between sleep and memory consolidation (Genzel et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of sex and menstrual phase on memory formation during a nap

Sattari

McDevitt

Panas

et al. 2017

Neurobiology of Learning and Memory

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Memory formation can be influenced by sleep and sex hormones in both men and women, and by the menstrual cycle in women. Though many studies have shown that sleep benefits the consolidation of memories, it is not clear whether this effect differs between men and women in general or according to menstrual phase in women. The present study investigated the effect of sex and menstrual cycle on memory consolidation of face-name associations (FNA) following a daytime nap. Recognition memory was tested using a face-name paired associates task with a polysomnographic nap between morning and evening testing. Seventeen healthy women (age: 20.75 (1.98) years) were studied at two time points of their menstrual cycles, defined from self-report and separated by 2 weeks (perimenses: -5 days to + 6 days from the start of menses, and non-perimenses: outside of the perimenses phase) and compared with eighteen healthy men (age: 22.01 (2.91) years). Regardless of menstrual phase, women had better pre-nap performance than men. Further, menstrual phase affected post-nap memory consolidation, with women showing greater forgetting in their perimenses phase compared with their nonperimenses phase, and men. Interestingly, post-nap performance correlated with electrophysiological events during sleep (slow oscillations, spindles, and temporal coupling between the two), however, these correlations differed according to menstrual phase and sex.Men's performance improvement was associated with the temporal coupling of spindles and slow oscillations (i.e., spindle/SO coincidence) as well as spindles. Women, however, showed an association with slow oscillations during non-perimenses, whereas when they were in their perimenses phase of their cycle, women appeared to show an association only with sleep spindle events for consolidation. These findings add to the growing literature demonstrating sex and menstrual phase effects on memory formation during sleep. THE EFFECT OF SEX AND MENSTRUAL CYCLE ON MEMORY 3

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 82%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of sex and menstrual phase on memory formation during a nap

Sattari

McDevitt

Panas

et al. 2017

Neurobiology of Learning and Memory

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show abstract

“…Sex differences were reported for the number of sleep spindles, spindle density, and EEG power (Gaillard and Blois, 1981;Carrier et al, 2001;Huupponen et al, 2002;Genzel et al, 2012) as well as functional correlates of spindles, namely, learning-related increases in spindle activity, which was only present in males and females in their mid-luteal menstrual phase (Genzel et al, 2012). Sex differences were also repeatedly shown for brain structures and neural correlates of cognitive performance (Cahill, 2006;Jazin and Cahill, 2010).…”

Section: Introductionmentioning

confidence: 99%

Sleep Spindles and Intelligence: Evidence for a Sexual Dimorphism

et al. 2014

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Sleep spindles are thalamocortical oscillations in nonrapid eye movement sleep, which play an important role in sleep-related neuroplasticity and offline information processing. Sleep spindle features are stable within and vary between individuals, with, for example, females having a higher number of spindles and higher spindle density than males. Sleep spindles have been associated with learning potential and intelligence; however, the details of this relationship have not been fully clarified yet. In a sample of 160 adult human subjects with a broad IQ range, we investigated the relationship between sleep spindle parameters and intelligence. In females, we found a positive age-corrected association between intelligence and fast sleep spindle amplitude in central and frontal derivations and a positive association between intelligence and slow sleep spindle duration in all except one derivation. In males, a negative association between intelligence and fast spindle density in posterior regions was found. Effects were continuous over the entire IQ range. Our results demonstrate that, although there is an association between sleep spindle parameters and intellectual performance, these effects are more modest than previously reported and mainly present in females. This supports the view that intelligence does not rely on a single neural framework, and stronger neural connectivity manifesting in increased thalamocortical oscillations in sleep is one particular mechanism typical for females but not males.

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Spindle–slow oscillation coupling correlates with memory performance and connectivity changes in a hippocampal network after sleep

Bastian

Samanta

Paula

et al. 2022

Human Brain Mapping

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After experiences are encoded, post‐encoding reactivations during sleep have been proposed to mediate long‐term memory consolidation. Spindle–slow oscillation coupling during NREM sleep is a candidate mechanism through which a hippocampal‐cortical dialogue may strengthen a newly formed memory engram. Here, we investigated the role of fast spindle‐ and slow spindle–slow oscillation coupling in the consolidation of spatial memory in humans with a virtual watermaze task involving allocentric and egocentric learning strategies. Furthermore, we analyzed how resting‐state functional connectivity evolved across learning, consolidation, and retrieval of this task using a data‐driven approach. Our results show task‐related connectivity changes in the executive control network, the default mode network, and the hippocampal network at post‐task rest. The hippocampal network could further be divided into two subnetworks of which only one showed modulation by sleep. Decreased functional connectivity in this subnetwork was associated with higher spindle–slow oscillation coupling power, which was also related to better memory performance at test. Overall, this study contributes to a more holistic understanding of the functional resting‐state networks and the mechanisms during sleep associated to spatial memory consolidation.

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Sex and modulatory menstrual cycle effects on sleep related memory consolidation

Cited by 111 publications

References 67 publications

The effect of sex and menstrual phase on memory formation during a nap

The effect of sex and menstrual phase on memory formation during a nap

Sleep Spindles and Intelligence: Evidence for a Sexual Dimorphism

Spindle–slow oscillation coupling correlates with memory performance and connectivity changes in a hippocampal network after sleep

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