Sex and strain as factors in voluntary alcohol intake

Gene markers for alcohol‐metabolizing enzymes among recombinant inbred strains of mice with differential behavioural responses towards alcohol

“…Studies on inbred strains of mice have demonstrated that alcohol preference and other alcohol-related behaviour ,have strong genetic components (McClearn & Rogers, 1959;Russell & Stern, 1973;Rogers & McClearn, 1975;Church, Fuller & Dann, 1979). When presented with a choice between water and 10 % ethanol in water, large inbred strain differences have been observed, particularly between C57BL strains, which consume approximately three-quarters of their fluid as 10 % ethanol, and strains such as D B N 2 , BALB/c and A, which consume very little ethanol (see Rogers, 1972).…”