Sex- and strain-related differences in first-pass alcohol metabolism in mice

D, Desroches; Orevillo, Chad; Verina, D.

doi:10.1016/0741-8329(94)00098-x

Cited by 30 publications

(12 citation statements)

References 26 publications

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“…A substantial amount of ethanol was consumed within the first 20 min of the drinking session and dialysate ethanol levels peaked 40–60 min later, an effect consistent with oral absorption of ethanol (Desroches et al 1995; Griffin et al 2007). Consistent with the greater amount of ethanol intake during the microdialysis session, EtOH mice evidenced higher peak brain ethanol levels that were sustained (relative to the CTL group) during the later time points of the drinking session as well as at least one hour following termination of ethanol access.…”

Section: Discussionmentioning

confidence: 77%

Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens

Griffin

López²,

Yanke³

et al. 2008

Psychopharmacology

126

148

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Rationale This study examined the relationship between voluntary ethanol consumption and ethanol concentrations measured in the nucleus accumbens of ethanol dependent and non-dependent C57BL/6J mice. Method Mice were offered ethanol in a 2-bottle choice, limited access paradigm and consummatory behavior was monitored with lickometers. After baseline intake stabilized, mice received chronic intermittent ethanol (EtOH group) or air (CTL group) exposure by inhalation (16 hr/day for 4 days) and then resumed drinking. Brain ethanol levels during voluntary drinking were measured by microdialysis procedures and compared to brain ethanol concentrations produced during chronic intermittent ethanol vapor exposure. Results Voluntary ethanol consumption progressively increased over repeated cycles of chronic intermittent ethanol exposure but remained unchanged in CTL mice. Analysis of lick patterns indicated EtOH mice consumed ethanol at a faster rate compared to CTL mice. The greater and faster rate of ethanol intake in EtOH mice produced higher peak brain ethanol concentrations compared to CTL mice and these levels were similar to levels produced during chronic intermittent ethanol exposure. Conclusions These results show that in this model of dependence and relapse drinking, dependent mice exhibit enhanced voluntary ethanol consumption relative to non-dependent controls, which consequently produces blood and brain ethanol concentrations similar to those experienced during chronic intermittent ethanol exposure.

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Section: Discussionmentioning

confidence: 77%

Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens

Griffin

López²,

Yanke³

et al. 2008

Psychopharmacology

126

148

View full text Add to dashboard Cite

show abstract

“…Balak et al re ported that developmental expressions of ADH in high (C57BL/6) arid low (C3H) ADH activity mice have also been investigated (17). It is generally accepted that rat liver ADH activity is known to be significantly lower in males than in females (18), but the activity of gastric ADH involved in the "first-pass alcohol metabolism" was higher in male mice than in female mice (19). The hepatic cytosolic ADH of rats were regulated by sex hor mones (18).…”

Section: Discussionmentioning

confidence: 92%

Gender-Related Differences in Mouse Hepatic Ethanol Metabolism.

Kishimoto

Ogishi

Ueda

et al. 2002

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Collins et al, 1975). In C57 and DBA mice, female mice show lower blood ethanol concentrations 30 min after intraperitoneal injection of ethanol (Desroches et al, 1995), a pattern of results important for consideration of the observed sex differences in ethanol-induced hyperglycemia.…”

Section: Discussionmentioning

confidence: 92%