Sex and Stress Steroid Crosstalk Reviewed: Give Us More

Kroon, Jan; Meijer, Onno C.

doi:10.1210/jendso/bvaa113

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Nonetheless, in this study we only focused on CECs, not taking into account other cell types that may be affected in CSC, such as the RPE or in the sclera. Although we did not observe AR expression in CECs, the high male preponderance in CSC may still be explained by crosstalk between corticosteroids and androgens in other cell types outside the choroid, a mechanism that has been linked to a sexual dimorphic response to corticosteroids ( 57 , 58 ).…”

Section: Discussioncontrasting

confidence: 68%

The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy

Brinks

Dijk

Kiełbasa

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context Central serous chorioretinopathy (CSC) is a severe ocular disease characterized by fluid accumulation under the retina and abnormalities in the underlying vascular layer, the choroid. CSC has a striking prevalence in males of 80-90% of total patients. Corticosteroids are the most pronounced extrinsic risk factor for CSC. Choroidal endothelial cells (CECs) are important for the vascular integrity of the choroid, but the effects of corticosteroid effects in these cells are unknown. Design and Objective We aimed to reveal the potential steroidal contribution to CSC. We characterized the expression of the glucocorticoid-, mineralocorticoid-, and androgen receptor in the human choroid, using immunohistochemistry. Using RNA-sequencing, we describe the cortisol response in human CECs derived from 5 male and 5 female postmortem donors. Results The glucocorticoid receptor was highly expressed in the human choroid, whereas no to minimal expression of the mineralocorticoid- and androgen receptors was observed. The extensive transcriptional response to cortisol in human primary cultured CECs showed interindividual differences, but very few sex differences. Several highly regulated genes such as ZBTB16 (log2 fold change males 7.9; females 6.2) provide strong links to choroidal vascular regulation. Conclusions The glucocorticoid receptor predominantly mediates the response to cortisol in human CECs. Interindividual differences are an important determinant regarding the cortisol response in human cultured CECs, whereas intrinsic sex differences appear less pronounced. The marked response of particular target genes in endothelial cells to cortisol, such as ZBTB16, warrants further investigation into their potential role in the pathophysiology of CSC and other vascular conditions.

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Section: Discussioncontrasting

confidence: 68%

The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy

Brinks

Dijk

Kiełbasa

et al. 2021

The Journal of Clinical Endocrinology &Amp; Metabolism

Self Cite

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“…For example, chronic psychologic stress contributes to sex-specific health effects via cross-talk between glucocorticoids and sex steroids. 5 Overlapping research links many of these exposures to respiratory health and related comorbidities (obesity) in a sex-specific manner.…”

mentioning

confidence: 99%

Hormones and women’s respiratory health across the lifespan: Windows of opportunity for advancing research

Wright¹

2021

Journal of Allergy and Clinical Immunology

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The development of novel glucocorticoid receptor antagonists: From rational chemical design to therapeutic efficacy in metabolic disease models

Kroon

Viho

Gentenaar

et al. 2021

Pharmacological Research

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Sex and Stress Steroid Crosstalk Reviewed: Give Us More

Cited by 3 publications

References 8 publications

The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy

The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy

Hormones and women’s respiratory health across the lifespan: Windows of opportunity for advancing research

The development of novel glucocorticoid receptor antagonists: From rational chemical design to therapeutic efficacy in metabolic disease models

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