Sex and the Risk of Restless Legs Syndrome in the General Population

Berger, Klaus; Luedemann, Jan; Trenkwalder, Claudia; John, Ulrich; Kessler, Christof

doi:10.1001/archinte.164.2.196

Cited by 679 publications

(501 citation statements)

References 28 publications

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“…This is interesting since the previous studies (Chervin et al 2002;Walters et al 2004) suggested an increased risk of having another of these disorders when one of them is present. Our fi ndings showed that RLS was quite frequent in subjects with ADHD (almost 34%) when compared with the prevalence rates obtained from epidemiological studies, which reported the prevalence of RLS as almost 11% (Berger et al 2004;Hogl et al 2005). Although we did not have a control group, consistent with previous studies (Cortese et al 2005), our results suggest that RLS is more common in subjects with ADHD than in normal population.…”

Section: Discussionsupporting

confidence: 55%

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Association between Low Serum Ferritin and Restless Legs Syndrome in Patients with Attention Deficit Hyperactivity Disorder

Öner¹,

Dirik²,

Taner

et al. 2007

Tohoku J. Exp. Med.

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Attention defi cit hyperactivity disorder (ADHD) is a neurobehavioral disorder characterized by pervasive inattention and/or hyperactivity-impulsivity. It has been suggested that ADHD symptoms are associated with restless legs syndrome (RLS), which is a neurological condition that is defi ned by an irresistible urge to move the legs. Increasing evidence suggests iron deficiency may underlie common pathophysiological mechanisms in subjects with ADHD and with RLS. To further defi ne the relationship between iron defi ciency and RLS in children and adolescents with ADHD, we evaluated 87 ADHD subjects: 79 boys and 8 girls with age 9.3 ± 2.5 years (6-16 years). Various psychopathologies and the severity of the ADHD symptoms and serum ferritin levels were assessed. Diagnosis of RLS was made according to the International RLS Group criteria. The patients were evaluated for the iron defi ciency (ferritin < 12 ng/ml). RLS was found in 29 (33.3%) of the 87 ADHD subjects. Parentand teacher-rated behavioral and emotional problems and the severity of ADHD symptoms were not signifi cantly different between ADHD subjects with RLS and those without RLS (n = 58). The rate of iron defi ciency was signifi cantly higher in ADHD subjects with RLS (n = 6, 20.7%) when compared with ADHD subjects without RLS (n = 1, 1.7%, p = 0.005). Our results showed that depleted iron stores might increase the risk of having RLS in ADHD subjects. Iron defi ciency, which is associated with both ADHD and RLS, seems to be an important modifying factor in the relationship between these two conditions. restless legs syndrome; attention defi cit hyperactivity disorder; iron defi ciency; ferritin; dopamine

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Section: Discussionsupporting

confidence: 55%

“…= 9.3 ± 2.5). All subjects were recruited from the general outpatient clinic of a is a common condition with a prevalence of almost 11% (Berger et al 2004;Hogl et al 2005). There are two types of RLS: idiopathic and symptomatic (secondary).…”

Section: Population and Samplingmentioning

confidence: 99%

Association between Low Serum Ferritin and Restless Legs Syndrome in Patients with Attention Deficit Hyperactivity Disorder

Öner¹,

Dirik²,

Taner

et al. 2007

Tohoku J. Exp. Med.

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“…In the group of patients with RLS, 25% of individuals had quitted smoking, but none reported active smoking. These correlations were not yet substantially proven by the studies evaluated, but it is recommended do not smoke at night because smoking can worse the RLS symptoms 16,17 .…”

Section: Resultsmentioning

confidence: 96%

“…Thus, there is no need for polysomnography except when there is suspicion of co-morbidities. Berger et al have used successfully this method 16 .…”

Section: Resultsmentioning

confidence: 99%

“…Berger et al demonstrated higher prevalence in women, but their results showed that nulliparous women had similar prevalence compared to males and that the number of pregnancies was associated with increased risk of being the bearer of RLS. The reason for this deterioration is related to the changes in the secretion of sex hormones during pregnancy (16). Regarding the male population, the prevalence of RLS was 5.76%.…”

Section: Resultsmentioning

confidence: 99%

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086 Restless Legs Syndrome – A Study of Prevalence Among Medical School Faculty Members

Haggstrãm¹,

Bigolin²,

Assoni³

et al. 2009

Sleep Medicine

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-The aim of this study was to assess the prevalence of idiopathic restless legs syndrome (RLS) and its correlations in a sample of Medical School faculty members. A transversal study was conducted at a Medical School in the south of Brazil included 78 faculty members. The subjects answered to a structured questionnaire specific to RLS diagnosis and the Epworth and the Stanford scales to measure daytime sleepiness. Severity of the disease was also evaluated. The variables were analyzed to statistical significance. RLS was diagnosed in 10.25% of the subjects evaluated and most were women (62.5%). The prevalence of daytime sleepiness was significantly greater among the subjects suffering from RLS (p=0.04). RLS subjects were significantly younger than the group without the syndrome (p=0.02). RLS had a considerable prevalence in the sample studied. Daytime sleepiness and young age showed an important correlation to this syndrome, as other potential factors were not confirmed.KEy WoRDS: restless leg syndrome, prevalence, idiopathic, daytime sleepness. síndrome das pernas inquietas: estudo de prevalência entre professores do curso de medicina Resumo -o objetivo deste estudo foi analisar a prevalência da síndrome das pernas inquietas (SPI) e suas implicações clínicas em uma amostra envolvendo docentes de um curso de Medicina. Foi realizado um estudo transversal que envolveu 78 docentes do curso de Medicina de uma Universidade do Sul do Brasil. os indivíduos avaliados responderam um questionário com perguntas epidemiológicas e de diagnóstico para SPI, assim como escalas de sonolência de Epworth e Stanford. os portadores de SPI responderam questionário de gravidade. As variáveis foram analisadas quanto à significância estatística. obtivemos uma prevalência de indivíduos portadores de SPI de 10,25%, sendo 62,5% destes do sexo feminino. A existência de sonolência diurna excessiva foi significativamente maior em pacientes portadores da síndrome (p=0,04). os pacientes portadores de SPI possuíam idade significativamente inferior ao grupo não sindrômico (p=0,02). A SPI mostrou-se bastante prevalente em nossa amostra. A prevalência de sonolência diurna e menos idade mostrou importante relação com esta síndrome, enquanto outros fatores possivelmente relacionados não foram confirmados.PALAvRAS-ChAvE: síndrome das pernas inquietas, prevalência, idiopática, sonolência diurna.

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