Sex and the Risk of Atheromatous and Nonatheromatous Cardiovascular Disease in CKD: Findings From the CKD-REIN Cohort Study

Faucon, Anne-Laure; Lambert, Oriane; Massy, Ziad; Drüeke, Tilman B.; Combe, Christian; Fouque, Denis; Frimat, Luc; Jacquelinet, Christian; Laville, Maurice; Liabeuf, Sophie; Pecoits-Filho, Roberto; Hauguel-Moreau, Marie; Mansencal, Nicolas; Alencar de Pinho, Natalia; Stengel, Bénédicte; Alencar de Pinho, Natalia; Cannet, Dorothée; Fouque, Denis; Frimat, Luc; Hamroun, Aghiles; Herpe, Yves-Edouard; Jacquelinet, Christian; Lambert, Oriane; Lange, Céline; Laville, Maurice; Liabeuf, Sophie; Massy, Ziad A.; Metzger, Marie; Morel, Pascal; Pascal, Christophe; Pecoits-Filho, Roberto; Stengel, Bénédicte; Azar, Raymond; Belenfant, Xavier; Besnier, Dominique; Bourdenx, Jean Philippe; Burtey, Stéphane; Chauveau, Dominique; Chazot, Charles; Choukroun, Gabriel; Combe, Christian; Delahousse, Michel; Deroure, Benjamin; Essig, Marie; Glowacki, François; Hannedouche, Thierry; Hoffmann, Maxime; Hourmant, Maryvonne; Jamali, Mohamed; Juillard, Laurent; Kamar, Nassim; Keller, Adrien; Klein, Alexandre; Kuentz, François; Lacraz, Adeline; Lambrey, Guy; Landru, Isabelle; Lang, Philippe; Lebrun, Gaetan; Lobbedez, Thierry; Magnant, Eric; Mailliez, Sébastien; Maisonneuve, Nathalie; Martin, Séverine; Moulin, Bruno; Noel, Christian; Panescu, Viktor; Sekhri, Hacène; Smati, Mustafa; Testa, Angelo; Thervet, Eric; Urena, Pablo; Vela, Carlos; Zaoui, Philippe

doi:10.1053/j.ajkd.2024.04.013

American Journal of Kidney Diseases

2024

DOI: 10.1053/j.ajkd.2024.04.013

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Sex and the Risk of Atheromatous and Nonatheromatous Cardiovascular Disease in CKD: Findings From the CKD-REIN Cohort Study

Anne-Laure Faucon,

Oriane Lambert,

Ziad Massy

et al.

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Cited by 3 publications

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Long-term Outcomes of Lupus Nephritis in Comparison to Other CKD Etiologies

Chrysostomou,

Faustini,

Gunnarsson

et al. 2025

Kidney International Reports

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Long-term Outcomes of Lupus Nephritis in Comparison to Other CKD Etiologies

Chrysostomou,

Faustini,

Gunnarsson

et al. 2025

Kidney International Reports

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Steps in the Right Direction: The Importance of High-Quality Sex- and Gender-Based Analyses in CKD and Cardiovascular Disease Research

Clemens,

Ahmed

2024

American Journal of Kidney Diseases

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Primary glomerular diseases and long‐term adverse health outcomes: A nationwide cohort study

Faucon,

Lando,

Chrysostomou

et al. 2024

J Intern Med

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BackgroundAlthough glomerular diseases are the third most frequent cause of end‐stage kidney disease worldwide, little is known about their long‐term outcomes.MethodsIn patients with chronic kidney disease (CKD) stage 3–5 enrolled in the Swedish Renal Registry, we compared risks of hospitalization, kidney replacement therapy (KRT), major cardiovascular events (MACE), and death of the four most frequent primary glomerular diseases (IgA nephropathy [IgAN], focal segmental glomerulosclerosis [FSGS], minimal change disease [MCD], and membranous nephropathy [MN]), and patients with CKD due to the most common non‐communicable diseases (control‐CKD).ResultsWe identified 2396 patients with glomerular disease (97% biopsy‐proven, 69% men, 57 years, eGFR 29 mL/min/1.73 m2, uACR 88 mg/mmol, 1524 with IgAN, 398 FSGS, 94 MCD, and 380 MN) and 37,697 controls (64% men, 74 years, eGFR 25 mL/min/1.73 m2, uACR 23 mg/mmol), mainly with diabetic nephropathy and nephroangiosclerosis. The median follow‐up was 6.3 (3.3; 9.9) years. Compared with control‐CKD, patients with primary glomerular diseases generally had a lower risk of hospitalization, MACE (adjusted hazard ratios [HRs] ranging from 0.44 to 0.88 depending on the etiology) and death (HRs ranging 0.45–0.76). Patients with IgAN and FSGS had a faster eGFR decline and a higher rate of KRT (HRs 1.26 [95%CI: 1.15–1.37] and 1.34 [1.15–1.57], respectively). Conversely, patients with MN and MCD had a lower KRT rate and slower eGFR decline.ConclusionDespite having a lower relative risk of hospitalization, cardiovascular events and mortality, patients with IgAN and FSGS are at higher risk of CKD progression than the most common etiologies of CKD, emphasizing the need for more stringent treatment strategies in these patients.

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Sex and the Risk of Atheromatous and Nonatheromatous Cardiovascular Disease in CKD: Findings From the CKD-REIN Cohort Study

Cited by 3 publications

References 56 publications

Long-term Outcomes of Lupus Nephritis in Comparison to Other CKD Etiologies

Long-term Outcomes of Lupus Nephritis in Comparison to Other CKD Etiologies

Steps in the Right Direction: The Importance of High-Quality Sex- and Gender-Based Analyses in CKD and Cardiovascular Disease Research

Primary glomerular diseases and long‐term adverse health outcomes: A nationwide cohort study

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