Sex-based differences in gallbladder cancer: An analysis of 257 patients.

Gupta, Vishal; Chandra, Abhijit; Kumar, Saket; Hatimi, Hunaid; Rahul, R; Gupta, V.

doi:10.1200/jco.2014.32.15_suppl.e15095

Cited by 4 publications

(4 citation statements)

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“…It is not well described why female patients have a higher rate of gallbladder cancer, but it is possibly due to risk factors such as gallstones, early menarche, late menopause, early first childbirth, and likely estrogen and progesterone receptors participating in the pathogenesis of GBC [ 22 ]. In our cohort, we found that 74% of patients were female, a number consistent with previous reports [ 21 , 22 ].…”

Section: Discussionsupporting

confidence: 92%

“…Gallbladder cancer affects women disproportionately, as noted by previous studies [ 21 , 22 ]. It is not well described why female patients have a higher rate of gallbladder cancer, but it is possibly due to risk factors such as gallstones, early menarche, late menopause, early first childbirth, and likely estrogen and progesterone receptors participating in the pathogenesis of GBC [ 22 ].…”

Section: Discussionmentioning

confidence: 73%

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Outcomes of patients with gallbladder cancer presenting with acute cholecystitis

Franco,

Lau,

Liu

et al. 2024

Langenbecks Arch Surg

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The main purpose of this study is to explore the outcomes of patients found to have gallbladder cancer during investigation and diagnosis of acute cholecystitis. The incidence of primary gallbladder cancer co-existing in acute cholecystitis is not well defined in the literature, with anecdotal reports suggesting that they experience worse outcomes than patients with gallbladder cancer found incidentally. Methods A retrospective review of all patients with gallbladder cancer managed at the Canberra Health Service between 1998 and May 2022 were identified and reviewed. Results A total of 65 patients were diagnosed with primary gallbladder cancer during the study period with a mean age of 70.4 years (SD 11.4, range 59–81.8 years) and a female preponderance (74% versus 26%) with a ratio of 2.8. Twenty (31%) patients presented with acute calculus cholecystitis and were found to have a primary gallbladder cancer. This group of patients were older and predominantly female, but the difference was not statistically significant. The overall 5-year survival in the cohort was 20% (stage 1 63%, stage 2 23%, stage 3 16%, and stage 4 0%). There was no statistically significant difference in survival between those who presented with acute cholecystitis vs other presentations. Conclusions A third of the patients with gallbladder cancer presented with acute cholecystitis. There was no statistically significant difference in survival in those with bile spillage during cholecystectomy as well those presenting with acute cholecystitis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 73%

Outcomes of patients with gallbladder cancer presenting with acute cholecystitis

Franco,

Lau,

Liu

et al. 2024

Langenbecks Arch Surg

View full text Add to dashboard Cite

show abstract

“…It is not well described why female patients have a higher rate of gallbladder cancer, but it is possibly due to risk factors such as gallstones, early menarche, late menopause, early rst childbirth and likely estrogen and progesterone receptors participating in the pathogenesis of GBC [20]. In our cohort, we found that 74% of patients were female, a number consistent with previous reports [19,20].…”

Section: Discussionsupporting

confidence: 90%

“…Gallbladder cancer affects women disproportionately, as noted by previous studies [19,20]. It is not well described why female patients have a higher rate of gallbladder cancer, but it is possibly due to risk factors such as gallstones, early menarche, late menopause, early rst childbirth and likely estrogen and progesterone receptors participating in the pathogenesis of GBC [20].…”

Section: Discussionmentioning

confidence: 91%

Outcomes of patients with gallbladder cancer presenting with acute cholecystitis

Franco

Lau

Liu

et al. 2023

Preprint

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The main purpose of this study is to explore the outcomes of patients with found to have gallbladder cancer after emergency cholecystectomy for acute cholecystitis versus those found incidentally. The true incidence of primary gallbladder cancer co-existing in acute cholecystitis is not defined especially in the Western population with high incidence of gallstone disease and a low incidence of gallbladder cancer. Methods A retrospective review of all patients with gallbladder cancer managed at the Canberra Health Service between 1998 and May 2022 were identified and reviewed. Results A total of 65 patients were diagnosed with primary gallbladder cancer during the study period with a mean age of 70.4 years (SD 11.4, range 59-81.8 years) and a female preponderance (74% versus 26%) with a ratio of 2.8. Twenty (31%) patients presented with acute calculus cholecystitis and were found to have a primary gallbladder cancer. This group of patients were older and predominantly female but the difference was not statistically significant. The overall 5-year survival in the cohort was 20% (stage 1-63%, stage 2- 23%, stage 3- 16% and stage 4- 0%). There was no statistically significant difference in survival between those who presented with acute cholecystitis vs other presentations. Conclusions A third of the patients with gallbladder cancer presented with acute cholecystitis. There was no statistically significant difference in survival in those with bile spillage during cholecystectomy as well those presenting with acute cholecystitis.

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Development of a nomogram to predict survival in advanced biliary tract cancer

Imaoka,

Ikeda,

Nomura

et al. 2023

Sci Rep

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The prognosis of advanced biliary tract cancer (BTC) patients remains poor due to limited efficacy of chemotherapy and difficulties in management. Thus, prediction of survival is crucial for the clinical management of advanced BTC. The aim was to develop and validate a nomogram to predict 6-month and 12-month survival in advanced BTC patients treated with chemotherapy. A multivariable Cox regression model was used to construct a nomogram in a training set (JCOG1113, a phase III trial comparing gemcitabine plus S-1 [GS] and gemcitabine plus cisplatin, n = 351). External validity of the nomogram was assessed using a test set (JCOG0805, a randomized, phase II trial comparing GS and S-1 alone, n = 100). Predictive performance was assessed in terms of discrimination and calibration. The constructed nomogram included lymph node metastasis, liver metastasis, carbohydrate antigen 19-9, carcinoembryonic antigen, albumin, and C-reactive protein. Uno’s concordance index was 0.661 (95% confidence interval [CI] 0.629–0.696) in the training set and 0.640 (95% CI 0.566–0.715) in the test set. The calibration plots for 6-month and 12-month survival showed good agreement in the two analysis sets. The present nomogram can facilitate prediction of the prognosis of advanced BTC patients treated with chemotherapy and help clinicians’ prognosis-based decision-making.

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Sex-based differences in gallbladder cancer: An analysis of 257 patients.

Cited by 4 publications

References 0 publications

Outcomes of patients with gallbladder cancer presenting with acute cholecystitis

Outcomes of patients with gallbladder cancer presenting with acute cholecystitis

Outcomes of patients with gallbladder cancer presenting with acute cholecystitis

Development of a nomogram to predict survival in advanced biliary tract cancer

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