Sex‐Based Differences in Revascularization Outcomes: Is It Time for a Dedicated Randomized Trial in Women?

Malick, Waqas; Soriano, Kevin; Stone, Gregg W.

doi:10.1161/jaha.121.024281

Cited by 1 publication

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Malick et al recently discussed the need for a dedicated randomized trial in women to further study the use of drug-eluting stents compared to surgery to address left main disease in this population [9]. They reviewed the EXCEL (Evaluation of XIENCE versus Coronary Artery Bypass Graft Surgery for Effectiveness of Left Main Revascularization), NOBLE (Nordic-Baltic-British Left Main Revascularization) and SYNTAX (TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries) trials and found that studies suggested a worse outcome in women compared to men undergoing percutaneous coronary interventions (PCI), although surprisingly no mortality difference when compared to CABG [9,14]. The issue still stands that several studies have shown increased mortality in women undergoing routine procedures.…”

Section: Discussionmentioning

confidence: 99%

“…Zwichenberger et al reported “female sex was associated with 14–22% lower odds of undergoing guideline concordant revascularization including use of left internal thoracic artery, multiarterial grafting, and complete revascularization in a large Society of Thoracic Surgery database study” [7 ▪ ]. Malick et al recently discussed the need for a dedicated randomized trial in women to further study the use of drug-eluting stents compared to surgery to address left main disease in this population [9]. They reviewed the EXCEL (Evaluation of XIENCE versus Coronary Artery Bypass Graft Surgery for Effectiveness of Left Main Revascularization), NOBLE (Nordic-Baltic-British Left Main Revascularization) and SYNTAX (TAXUS Drug-Eluting Stent Versus Coronary Artery Bypass Surgery for the Treatment of Narrowed Arteries) trials and found that studies suggested a worse outcome in women compared to men undergoing percutaneous coronary interventions (PCI), although surprisingly no mortality difference when compared to CABG [9,14].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cardiovascular disease, surgery and outcomes in women: are they any different

Klein¹

2022

Current Opinion in Anaesthesiology

View full text Add to dashboard Cite

Purpose of reviewCardiovascular disease is a leading cause of death for women worldwide and continues to be a major determinant of significant morbidity. Several studies have investigated the marked differences in diagnosis, treatment and etiology in cardiovascular disease and how it relates to gender. In this review, several key studies highlight the stark differences and bring light to the disparity and potential opportunities for further research. Recent findingsOne noted area of gender disparity is ischemic cardiac disease as it relates to surgical management. Women have historically had delays in diagnosis, inferior surgical revascularization techniques, and inadequate postoperative care when compared to men. SummaryBy highlighting the disparities in cardiovascular ischemic care, the hope is to bring attention and future research to a population group that is currently undertreated for their ischemic disease and suffering high mortality rates.

show abstract

Section: Discussionmentioning

confidence: 99%