Sex-Based Disparities in Outcomes With Abdominal Aortic Aneurysms

Sciria, Christopher; Osorio, Benedict; Wang, Joseph; Lu, Daniel Y.; Amin, Nivee; Vohra, Adam; Yeo, Ilhwan; Feldman, Dmitriy N.; Cheung, Jim W.; Narula, Nupoor; Wong, Sandy; Kim, Luke K.

doi:10.1016/j.amjcard.2021.06.023

Cited by 8 publications

(3 citation statements)

References 26 publications

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“… 37 Within the United States, there are discrepancies among the professional society guidelines for abdominal aortic aneurysm (AAA) screening for women compared with men. 38 Moreover, female sex has previously been reported as an independent predictor of mortality among both ruptured and elective AAA repair groups. 38 …”

Section: Discussionmentioning

confidence: 98%

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Demographic and Regional Trends of Mortality in Patients With Aortic Dissection in the United States, 1999 to 2019

Nazir

Ariss

Minhas

et al. 2022

JAHA

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Background Aortic dissection (AoD) is associated with high morbidity and mortality. However, the burden of AoD mortality is not well characterized, and contemporary data and mortality trends in different demographic and geographic subgroups have not been described. Methods and Results Trends in AoD mortality were assessed using a cross‐sectional analysis of the Centers for Disease Control and Prevention Wide‐Ranging Online Data for Epidemiologic Research database. Crude and age‐adjusted mortality rates (AAMR) per 1 million people with associated annual percent changes were determined. Joinpoint regression was used to assess trends in the overall sample and different demographic (sex, race and ethnicity, age) and geographic subgroups. Between 1999 and 2019, a total of 86 855 AoD deaths occurred within the United States. In the overall population, AAMR was 21.1 per 1 million in 1999 and 21.3 in 2019. After an initial decline in mortality, AAMR increased from 2012 to 2019, with an associated annual change of 2.5% (95% CI, 1.8–3.3). Men, older adults (aged ≥85 years), and non‐Hispanic Black or African American individuals had higher mortality rates than women, younger individuals, and other racial and ethnic individuals, respectively. Despite lower AAMRs throughout the study period, women experienced greater increases in AAMR from 2012 to 2019 compared with men. Similarly, non‐Hispanic Black or African American individuals had a pronounced increase in AAMR from 2012 to 2019. Conclusions Despite an initial decline in AoD mortality, the mortality rate has been increasing from 2012 to 2019, with pronounced increases among women and non‐Hispanic Black or African American individuals.

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Section: Discussionmentioning

confidence: 98%

“… 38 Moreover, female sex has previously been reported as an independent predictor of mortality among both ruptured and elective AAA repair groups. 38 …”

Section: Discussionmentioning

confidence: 98%

Demographic and Regional Trends of Mortality in Patients With Aortic Dissection in the United States, 1999 to 2019

Nazir

Ariss

Minhas

et al. 2022

JAHA

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show abstract

“…58 Others have found inferior outcomes for both open and endovascular approaches among women undergoing elective AAA repair. 59,60 Further work will be critical to understand whether these disparities are driven by technical factors making aneurysm repair more complicated in women or physiological factors, such as the later age at presentation.…”

Section: Abdominal Aortic Diseasementioning

confidence: 99%

Sex and Gender Differences in Aortic Disease

Huckaby,

Leshnower

2023

US Cardiol

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Dilatation of the thoracic or abdominal aorta can progress to dissection or rupture with significant associated morbidity and mortality. Aortic disease remains a treatable contributor to mortality in the US and its burden is likely underestimated. Recent clinical studies have uncovered sex and gender distinctions in the epidemiology, pathophysiology, and outcomes of aortic disease. Despite this, there has been little progress in the application of these findings to clinical practice. Improved understanding of the sex-specific mechanisms of aortic disease may inform personalized indications for elective repair and thus reduce the morbidity of aortic catastrophe. The objective of this review is to summarize known clinical and biological sex differences in both thoracic and abdominal aortic disease and highlight promising areas for future investigation.

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Abdominal Aortic Aneurysms (Etiology, Epidemiology, and Natural History)

Calgi

McNeil

2022

Anesthesiology Clinics

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Sex-Based Disparities in Outcomes With Abdominal Aortic Aneurysms

Cited by 8 publications

References 26 publications

Demographic and Regional Trends of Mortality in Patients With Aortic Dissection in the United States, 1999 to 2019

Demographic and Regional Trends of Mortality in Patients With Aortic Dissection in the United States, 1999 to 2019

Sex and Gender Differences in Aortic Disease

Abdominal Aortic Aneurysms (Etiology, Epidemiology, and Natural History)

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