Sex based pharmacological treatment in patients with metabolic syndrome: Findings from the Isfahan healthy heart program

Abstract

Pharmacological therapy is a critical step in the management of individuals with the metabolic syndrome (MetS) when lifestyle modifications cannot achieve the therapeutic goals. However, it has been well-documented that there is no single best therapy other than weight loss, and that treatment should be targeted at individual components of the MetS. The objective of this study was to investigate the treatment of individual components of the MetS in a population-based sample of individuals with clustering MetS components. In a cross-sectional population-based survey, we studied a randomly collected sample of men and women who had participated in the baseline survey of a community-based program in three Central Iranian counties in 2000 to 2001. Demographic data, medical status, and drug history were obtained by questionnaire. We evaluated the association between clustering of the MetS components and pharmacological treatment of cardiovascular risk factors. The most common pharmacologic agents prescribed for individuals with the MetS were beta-blockers (72.8%), followed by lipid-lowering agents (36%) with no significant gender difference. A high level of compliance with drug treatment was noted. Further research is warranted to understand the compliance behavior of patients with the MetS.

Role of gender in explaining metabolic syndrome risk factors in an Iranian rural population using structural equation modelling

“…Higher level of income can lead to an increase in quality of life and prevent the prevalence of MetS risk factors. This contrary relationship between social status and the prevalence of MetS among the Iranian population has also been reported in previous studies 90 , 91 . Another finding from this study was that females with lower social status are more susceptible to increase prevalence of MetS compared with males, which was consistent with previous studies 92 , 93 .…”

Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies

“…Epigenetic modifications, such as DNA methylation and histone acetylation, can modulate the expression of key genes involved in glycemic regulation, potentially predisposing individuals to metabolic disorders later in life [ 52 , 53 ]. Importantly, these epigenetic changes may exhibit sex-specific patterns due to differences in sex chromosome composition and hormonal regulation of epigenetic machinery [ 54 – 56 ].…”