Sex dependent alterations of resveratrol on social behaviors and nociceptive reactivity in VPA-induced autistic-like model in rats

Juybari, Kobra Bahrampour; Sepehri, Gholamreza; Meymandi, Manzumeh Shamsi; Shahrbabaki, Seyyed Sajjad Vakili; Moslemizadeh, Amirhossein; Saeedi, Nima; Aminzadeh, Azadeh; Nozari, Masoumeh; Khaksari, Mohammad; Haghpanah, Tahereh; Bashiri, Hamideh

doi:10.1016/j.ntt.2020.106905

Cited by 16 publications

(11 citation statements)

References 57 publications

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“…On the other hand, this study was focused on female sex since it is known that females show higher prevalence of chronic pain and higher vulnerability in the development of comorbid pain and emotional disorders 93 , 94 . However, considering evidence suggesting that the analgesic effects of plant extracts or solutions of polyphenols could be influenced by gender 95 , 96 , the effects of GSE and CE may be also studied in male in future experiments.…”

Section: Discussionmentioning

confidence: 99%

Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury-induced neuropathic pain development in ICR-CD1 female mice

Bagó-Mas

Korimová

Deulofeu

et al. 2022

Sci Rep

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More than half of spinal cord injury (SCI) patients develop central neuropathic pain (CNP), which is largely refractory to current treatments. Considering the preclinical evidence showing that polyphenolic compounds may exert antinociceptive effects, the present work aimed to study preventive effects on SCI-induced CNP development by repeated administration of two vegetal polyphenolic extracts: grape stalk extract (GSE) and coffee extract (CE). Thermal hyperalgesia and mechanical allodynia were evaluated at 7, 14 and 21 days postinjury. Then, gliosis, ERK phosphorylation and the expression of CCL2 and CX3CL1 chemokines and their receptors, CCR2 and CX3CR1, were analyzed in the spinal cord. Gliosis and CX3CL1/CX3CR1 expression were also analyzed in the anterior cingulate cortex (ACC) and periaqueductal gray matter (PAG) since they are supraspinal structures involved in pain perception and modulation. GSE and CE treatments modulated pain behaviors accompanied by reduced gliosis in the spinal cord and both treatments modulated neuron-glia crosstalk-related biomolecules expression. Moreover, both extracts attenuated astrogliosis in the ACC and PAG as well as microgliosis in the ACC with an increased M2 subpopulation of microglial cells in the PAG. Finally, GSE and CE prevented CX3CL1/CX3CR1 upregulation in the PAG, and modulated their expression in ACC. These findings suggest that repeated administrations of either GSE or CE after SCI may be suitable pharmacologic strategies to attenuate SCI-induced CNP development by means of spinal and supraspinal neuroinflammation modulation.

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Section: Discussionmentioning

confidence: 99%

Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury-induced neuropathic pain development in ICR-CD1 female mice

Bagó-Mas

Korimová

Deulofeu

et al. 2022

Sci Rep

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“…; different effects on VPA-induced autistic behaviors in six studies. On the one hand, four studies demonstrated that prenatal RSV treatment could reverse VPA-induced social deficits (31,36,38,43). Moreover, RSV also prevented sensory deficits triggered by VPA (34).…”

Section: Resveratrolmentioning

confidence: 99%

Nrf2 Activators as Dietary Phytochemicals Against Oxidative Stress, Inflammation, and Mitochondrial Dysfunction in Autism Spectrum Disorders: A Systematic Review

Yang

2020

Front. Psychiatry

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Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder with limited available treatments and diverse causes. In ASD patients, numerous researches demonstrated various alterations in inflammation/immune, oxidative stress, and mitochondrial dysfunction, and these alterations could be regulated by Nrf2. Hence, we aimed to systematically review the current evidence about the effects of Nrf2 activator supplementation on ASD objects from in vitro studies, animal studies, and clinical studies. Relevant articles were retrieved through searching for the Cochrane Library, PubMed, Web of Science, Scope, Embase, and CNKI databases (through September 23, 2020). Ultimately, we identified 22 preclinical studies, one cell culture study, and seven clinical studies, covering a total of five Nrf2 activators. For each Nrf2 activator, we focused on its definition, potential therapeutic mechanisms, latest research progress, research limitations, and future development directions. Our systematic review provided suggestive evidence that Nrf2 activators have a potentially beneficial role in improving autism-like behaviors and abnormal molecular alterations through oxidant stress, inflammation, and mitochondrial dysfunction. These dietary phytochemicals are considered to be relatively safer and effective for ASD treatment. However, there are few clinical studies to support the Nrf2 activators as dietary phytochemicals in ASD, even though several preclinical studies. Therefore, caution should be warranted in attempting to extrapolate their effects in human studies, and better design and more rigorous research are required before they can be determined as a therapeutic option.

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“…It was dissolved in distilled water (DW) (0.001–0.1 mg/kg in a constant volume of 10 mL/kg body weight). DW (10 mL/kg) was also utilized to gavage half of the pregnant rats (Fontes‐Dutra et al, 2018; Freitas et al, 2014; Juybari et al, 2020). The following groups were specified to randomly assign pup rats with or without VPA injection: Non‐VPA‐DW group: At GD 12.5, the pregnant rats received saline, and from GD 6.5 to GD 18.5, they were gavaged with DW. (II‐IV) Non‐VPA‐AG groups: At GD 12.5, the pregnant rats received saline, and from GD 6.5 to GD 18.5, AG was used to gavage the animals at dosages of 0.001, 0.01, and 0.1 mg/kg.…”

Section: Methodsmentioning

confidence: 99%

Agmatine ameliorates valproic acid‐induced depletion of parvalbumin‐positive neuron

Khoram‐Abadi,

Basiri,

Nemati

et al. 2024

Intl J of Devlp Neuroscience

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Autism spectrum disorder (ASD) is a widespread neurodevelopmental disorder with unknown etiology. Dysfunction of several brain areas including the prefrontal cortex (PFC), hippocampus, and cerebellum is involved in cognitive and behavioral deficits associated with ASD. Several studies have reported a reduction in the number of parvalbumin‐immunoreactive (PV+) neurons in brain areas of ASD patients and animal models such as a shank mutant mouse model and rodents receiving fetal valproic acid (VPA) administration. Developing therapeutic interventions that restore PV interneurons can be the future therapeutic approach to ASD. The present study examined the possible effect of agmatine (AG), an endogenous NMDA antagonist, on the number of PV+ neurons in a VPA animal model of autism. The therapeutic effects of AG in ameliorating ASD‐like behaviors were previously reported in VPA rats. AG was gavaged at dosages of 0.001, 0.01, and 0.1 mg/kg from gestational day (GD) 6.5 to 18.5, and the number of PV interneurons was analyzed by immunohistochemistry in the 1‐month‐old rats. Prenatal VPA (GD 12.5) or AG led to a decrease of PV neurons in the PFC, Cornu ammonia (CA1), and molecular layers (MLs) of the cerebellum. However, exposure to AG restored the PV population induced by VPA. AG may modify underlying neuronal mechanisms resulting in the increased survival or restoration of the PV population.

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Sex dependent alterations of resveratrol on social behaviors and nociceptive reactivity in VPA-induced autistic-like model in rats

Cited by 16 publications

References 57 publications

Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury-induced neuropathic pain development in ICR-CD1 female mice

Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury-induced neuropathic pain development in ICR-CD1 female mice

Nrf2 Activators as Dietary Phytochemicals Against Oxidative Stress, Inflammation, and Mitochondrial Dysfunction in Autism Spectrum Disorders: A Systematic Review

Agmatine ameliorates valproic acid‐induced depletion of parvalbumin‐positive neuron

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