2021
DOI: 10.1038/s41598-021-83896-5
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Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice

Abstract: A growing body of evidence suggests a relationship between olfactory dysfunction and the pathogenesis of mental disorders. Our previous studies indicated that chronic nasal inflammation caused loss of olfactory sensory neurons and gross atrophy of the olfactory bulb, which may lead to olfactory dysfunction. Simultaneously, increasing numbers of reports have elucidated the importance of gut microbiota to maintain brain function and that dysbiosis may be associated with neuropsychiatric disorders. Here we examin… Show more

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Cited by 5 publications
(6 citation statements)
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“…However, we did not see a significant change in female rats. These sex-specific effects are in accordance with the earlier study in mice . We also found restoration of intestinal bacterial abundance and propionate and butyrate in fecal samples after Cognisol treatment in CUMS rats.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…However, we did not see a significant change in female rats. These sex-specific effects are in accordance with the earlier study in mice . We also found restoration of intestinal bacterial abundance and propionate and butyrate in fecal samples after Cognisol treatment in CUMS rats.…”
Section: Discussionsupporting
confidence: 92%
“…These sex-specific effects are in accordance with the earlier study in mice. 110 We also found restoration of intestinal bacterial abundance and propionate and butyrate in fecal samples after Cognisol treatment in CUMS rats. Noteworthily, butyrate and propionate were reported to cross the blood−brain barrier and produce antidepressantlike effects.…”
Section: Acssupporting
confidence: 58%
“…Based on a growing body of literature showing sex differences in gut/fecal microbiota composition (Mishima et al, 2021), α‐ and β‐diversity were further analyzed, as above, further stratifying by sex. For observed richness, a two‐way ANOVA identified a main effect of prenatal treatment [ F (1, 12) = 7.796, ω 2 = 0.30, p = 0.02] and a trend for an interaction between prenatal treatment and sex [ F (1, 12) = 3.322, ω 2 = 0.13, p = 0.09].…”
Section: Resultsmentioning
confidence: 99%
“…Our analysis of microbial diversity revealed elevations in α‐diversity following PAE, an effect that was specifically driven by males. Importantly, while the literature is sparse in this area, there is evidence for male‐driven increases in microbial diversity in other challenge models; for example, chronic nasal inflammation has been shown to increase fecal microbiota diversity specifically in males (Mishima et al, 2021). While further research in this area is clearly needed, the overall sensitivity of males in this context may suggest that the male microbiome may be more susceptible to environmental/experimental manipulations, including that of PAE.…”
Section: Discussionmentioning
confidence: 99%
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