Sex-dependent effects of amygdaloid lesions on the social play of prepubertal rats

Meaney, Michael J.; Dodge, Anthony M.; Beatty, William W.

doi:10.1016/0031-9384(81)90175-x

Cited by 116 publications

(51 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, it appears that the neocortex is not necessary for the initiation of play behaviour, as neonatal decortication does not affect its appearance or its vigour (Murphy, MacLean, &Hamilton, 1981;Panksepp, Normansell, Cox, & Siviy, 1994). On the other hand, there is extensive evidence of subcortical involvement, particularly of the amygdala (Meaney, Dodge, & Beatty, 1981;Panksepp et al, 1984), areas of the thalamus and brainstem (Siviy & Panksepp, 1985, 1987, as well as the tectum, periaqueductal gray and hypothalamus (Gordon, Kollack-Walker, Akil, & Panksepp, 2002).…”

Section: Domain Of ''Moderate'' Intensitymentioning

confidence: 99%

Variation and homogeneity in affective responses to physical activity of varying intensities: An alternative perspective on dose – response based on evolutionary considerations

Ekkekakis

Hall

Petruzzello

2005

Journal of Sports Sciences

309

325

View full text Add to dashboard Cite

A model for systematic changes in patterns of inter-individual variation in affective responses to physical activity of varying intensities is presented, as a conceptual alternative to the search for a global dose -response curve. It is theorized that trends towards universality will emerge in response to activities that are either generally adaptive, such as moderate walking, or generally maladaptive, such as strenuous running that requires anaerobic metabolism and precludes the maintenance of a physiological steady state. At the former intensity the dominant response will be pleasure, whereas at the latter intensity the dominant response will be displeasure. In contrast, affective responses will be highly variable, involving pleasure or displeasure, when the intensity of physical activity approximates the transition from aerobic to anaerobic metabolism, since activity performed at this intensity entails a trade-off between benefits and risks. Preliminary evidence in support of this model is presented, based on a reanalysis of data from a series of studies.

show abstract

Section: Domain Of ''Moderate'' Intensitymentioning

confidence: 99%

Variation and homogeneity in affective responses to physical activity of varying intensities: An alternative perspective on dose – response based on evolutionary considerations

Ekkekakis

Hall

Petruzzello

2005

Journal of Sports Sciences

309

325

View full text Add to dashboard Cite

show abstract

“…The goal of this investigation is to confirm and extend gender differences (Beatty, Dodge, Traylor, et al, 1982;Meaney, Dodge, & Beatty, 1981;Meaney & Stewart, 1981) and social isolation effects (panksepp & Beatty, 1980) in play solicitation of juveniles observed in pairs or larger groups. We anticipated comparable results with individual subjects exposed to nonplayful social stimuli.…”

Section: Methodsmentioning

confidence: 99%

Play-solicitation behavior in juvenile male and female rats

Thor¹,

Holloway²

1983

Animal Learning & Behavior

View full text Add to dashboard Cite

“…Castration in adulthood decreases MeApd volume in males, and androgen treatment increases MeApd volume in adult females (Cooke et al, 1999); however, studies on juvenile rough-and-tumble play suggest that the MeA may be sexually dimorphic before puberty. Testosterone implants in the MeA masculinize the frequency of juvenile play (Meaney and McEwen, 1986), whereas bilateral destruction of the amygdala feminizes play frequency (Meaney et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Sexually Dimorphic Synaptic Organization of the Medial Amygdala

2005

View full text Add to dashboard Cite

The medial amygdala is important in social behaviors, many of which differ between males and females. The posterodorsal subnucleus of the medial amygdala (MeApd) is particularly sensitive to gonadal steroid hormones and is a likely site for gonadal hormone regulation of sexually dimorphic social behavior. Here we show that the synaptic organization of the MeApd in the rat is sexually dimorphic and lateralized before puberty. With the use of whole-cell voltage-clamp recording and quantitative electron microscopy, we found that, specifically in the left hemisphere, prepubertal males have ϳ80% more excitatory synapses per MeApd neuron than females. In the left but not the right MeApd, miniature EPSC (mEPSC) frequency was significantly greater in males than in females; mEPSC amplitude was not sexually dimorphic. Paired-pulse facilitation of EPSCs, an index of release probability, also was not sexually dimorphic, suggesting that greater mEPSC frequency is caused by a difference in excitatory synapse number. Electron microscopy confirmed that the asymmetric synapse-to-neuron ratio and the total asymmetric synapse number were significantly greater in the left MeApd of males than of females. In contrast to results for excitatory synapses, we found no evidence of sexual dimorphism or laterality in inhibitory synapses. Neither the frequency nor the amplitude of mIPSCs was sexually dimorphic or lateralized. Likewise, the number of symmetric synapses measured with electron microscopy was not sexually dimorphic. These findings show that the excitatory synaptic organization of the left MeApd is sexually differentiated before puberty, which could provide a sexually dimorphic neural substrate for the effects of hormones on adult social behavior.

show abstract

Sex-dependent effects of amygdaloid lesions on the social play of prepubertal rats

Cited by 116 publications

References 15 publications

Variation and homogeneity in affective responses to physical activity of varying intensities: An alternative perspective on dose – response based on evolutionary considerations

Variation and homogeneity in affective responses to physical activity of varying intensities: An alternative perspective on dose – response based on evolutionary considerations

Play-solicitation behavior in juvenile male and female rats

Sexually Dimorphic Synaptic Organization of the Medial Amygdala

Contact Info

Product

Resources

About