Sex dependent effects of silver nanoparticles on the zebrafish gut microbiota

Ma, Yanbo; Song, Liyan; Lei, Yu; Jia, Pan‐Pan; Lu, Chihua; Wu, Jianfeng; Xi, Chuanwu; Strauss, Phyllis R.; Pei, De‐Sheng

doi:10.1039/c7en00740j

Cited by 59 publications

(43 citation statements)

References 59 publications

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“…To take an example, male zebrafish were more susceptible to the NMs' exposure, compared to female zebrafish. [114] In addi tion, freshly prepared Ag NMs gave rise to more serious toxicity on gut microbiota due to the release of higher concentration of Ag + than that of stale Ag NMs. [112] In a recent work, to delin eate the antibacterial mechanism of silver nanomaterials, we compared the antibacterial activity of Ag NMs against two ben eficial lactobacilli (Lactobacillus delbrueckii subsp.…”

Section: Effects Of Nanomaterials On Gut Microbiotamentioning

confidence: 99%

The Nano–Intestine Interaction: Understanding the Location‐Oriented Effects of Engineered Nanomaterials in the Intestine

Cui

Bao

Wang

et al. 2020

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smll.201907665. Engineered nanomaterials (ENMs) are used in food additives, food packages, and therapeutic purposes owing to their useful properties, Therefore, human beings are orally exposed to exogenous nanomaterials frequently, which means the intestine is one of the primary targets of nanomaterials. Consequently, it is of great importance to understand the interaction between nanomaterials and the intestine. When nanomaterials enter into gut lumen, they inevitably interact with various components and thereby display different effects on the intestine based on their locations; these are known as location-oriented effects (LOE). The intestinal LOE confer a new biological-effect profile for nanomaterials, which is dependent on the involvement of the following biological processes: nanomucus interaction, nano-intestinal epithelial cells (IECs) interaction, nanoimmune interaction, and nano-microbiota interaction. A deep understanding ofNM-induced LOE will facilitate the design of safer NMs and the development of more efficient nanomedicine for intestine-related diseases. Herein, recent progress in this field is reviewed in order to better understand the LOE of nanomaterials. The distant effects of nanomaterials coupling with microbiota are also highlighted. Investigation of the interaction of nanomaterials with the intestine will stimulate other new research areas beyond intestinal nanotoxicity. www.advancedsciencenews.com

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Section: Effects Of Nanomaterials On Gut Microbiotamentioning

confidence: 99%

The Nano–Intestine Interaction: Understanding the Location‐Oriented Effects of Engineered Nanomaterials in the Intestine

Cui

Bao

Wang

et al. 2020

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“…Sex is documented to influence both gut microbiota composition (Bolnick et al 2014;Haro et al 2016), as well as the microbiome responses. Exposure to silver nanoparticles was for example shown to modify the gut microbiota structure of male but not female zebrafish (Ma et al 2018). Interestingly, sex-differentiated responses to compounds are also commonly reported in classical toxicology studies, for example in medaka fish exposed to cyanotoxins (Le Manach et al 2016).…”

Section: Correlation Versus Causality: Confounding Factors Should Notmentioning

confidence: 83%

Microbiome-aware Ecotoxicology: Relevance, Pitfalls and Challenges

Duperron¹,

Halary²,

Gallet³

et al. 2020

Preprint

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The diversity and significance of host-associated microbial communities has emerged over the last 15 years to the point when some may now assume that “Nothing in Biology makes sense except in the light of the microbiome”. The advent of high-throughput ‘omics’ techniques has revealed the multiple roles and interactions occurring among hosts, their microbial partners and their environment, and has radically changed our views of biology, evolution and individuality. Sit at the interface between a host and its environment, the microbiome is a dynamic interface that responds to both host and environmental factors, for better or worse. For this reason, the microbiome now appears as a relevant, yet understudied compartment for ecotoxicology research. Various examples show that the microbiome reacts to and interacts with contaminants, with consequences for hosts and the ecosystem, and great advances can be expected from studies in which microbiome research meets toxicology. Yet, for the encounter to be scientifically productive, caution is needed in study design, inferences and extrapolations. In this paper, we emphasize the relevance and challenges of microbiome research in environmental toxicology through documented examples, and draw readers attention to pitfalls that should not be overlooked when producing and analyzing their data. We advocate for the development of a “microbiome-aware ecotoxicology”.

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“…The result showed that the taxonomic information of total samples was 18 Phyla, 34 Classes, 87 Orders, 144 Families, 247 Genera, 324 Species, and 406 OTUs. According to our previous studies [23,37], the composition and functions of intestinal microbiota in female and male zebrafish were different, thus the following analysis of each group was departed by gender. The groups were marked by female and male in control (F-0 and M-0), female and male in 100 μg/L DEHP group (F-100 and M-100).…”

Section: Diversity and Richness Of Intestinal Microbiota In Adult Zebmentioning

confidence: 99%

“…The intestinal microbiota of male and female zebrafish was detected via the high-throughput sequencing, and the analysis methods were performed according to previous reports [23,37]. Briefly, the total genomic DNA of intestinal samples was extracted and purified with FastDNA ® SPIN Kit for Soil (Mpbio, USA).…”

Section: The Analysis Of Zebrafish Intestinal Microbiota By 16s Rrna mentioning

confidence: 99%

“…Thus, it usually applied as a credible animal model to evaluate the toxicity of various environmental pollutants including DEHP [22]. Moreover, the zebrafish model was recently used to study the functions and impacts of various pollutants on gut microbiota after acute or chronic exposure [23,24]. Moreover, zebrafish can be employed to study the relationship of microbes, stress response, and gut development [25,26].…”

Section: Introductionmentioning

confidence: 99%

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DEHP chronic exposure disturbs the gut microbial community and metabolic homeostasis: Gender-based differences in zebrafish

Pei

Jia

Xin

et al. 2020

Preprint

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Background: Di-(2-ethylhexyl) phthalate (DEHP), a predominant phthalate ester (PAE), exhibits various toxic potentials with environmental and human health risks. However, the chronic effects of DEHP exposure on gut microbiota and associated host’s health are still largely unexplored. Here, zebrafish were exposed to relative environmental levels (0-100 μg/L) of DEHP from embryos to adult (3.5 months), then the developmental indexes and microbiota as well as the related energy metabolites in gut tissues were checked to unveil the effects during the growth progress. Results: The results indicated that the composition of gut microbiota was different among male and female adult zebrafish, and DEHP disrupted the diversity and richness of the bacterial community. The histopathological analysis of intestinal tissues revealed the decrease of villus length and tunica muscularis thickness, especially the goblet cells per villi in male fish. Moreover, energy metabolites in gut tissues were actively increased at lower levels groups, which probably contribute to the condition factor of host. For immune-related genes, the expression levels of il-8 was increased both in female and male fish in the lowest concentration (10 μg/L), but the tlr-5 and il-1β genes were in the different response with significantly decreased in female fish. Conclusion: Taken all together, those results indicated that chronic exposure to DEHP led to zebrafish obesity with the disturbed bacterial community in the gut and related metabolism pathways. Those findings provided deep insights on the perturbation of gut microbiota, metabolic homeostasis, and gender-based differences by DEHP exposure.

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Sex dependent effects of silver nanoparticles on the zebrafish gut microbiota

Abstract: Silver nanoparticles (AgNPs), the most prevalent commercial nanomaterial products, are widely released into the environment.

Cited by 59 publications

References 59 publications

The Nano–Intestine Interaction: Understanding the Location‐Oriented Effects of Engineered Nanomaterials in the Intestine

The Nano–Intestine Interaction: Understanding the Location‐Oriented Effects of Engineered Nanomaterials in the Intestine

Microbiome-aware Ecotoxicology: Relevance, Pitfalls and Challenges

DEHP chronic exposure disturbs the gut microbial community and metabolic homeostasis: Gender-based differences in zebrafish

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