Sex Dependent Intergenerational Effects of Lead in Mouse Model
Nelly Banda,
Nyein Soe,
John Yabe
et al.
Abstract:Lead contaminated soils remains one of the major sources of lead (Pb) exposure with high impact on fertility in both males and females, pregnancy outcomes and child brain development. We investigated inhalation and ingestion as medium of Pb exposure via soil in male and female mice. Exposure was then withdrawn prior to mating thus we investigated the lingering effects of Pb on fertility in F0 generation and neurological development in F1 generation. Lead exposure reduced conception rates with a cumulative decr… Show more
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