Sex determines which section of the SLC6A4 gene is linked to obsessive–compulsive symptoms in normal Chinese college students

Lei, Xin; Chen, Chuansheng; He, Qinghua; Moyzis, Robert K.; Xue, Gui; Chen, Xiongying; Cao, Zhongyu; Li, Jin; He, Li; Zhu, Bi; Hsu, Anna Shan Chun; Li, Sufang; Li, Jun; Dong, Qi

doi:10.1016/j.jpsychires.2012.05.002

Cited by 16 publications

(9 citation statements)

References 78 publications

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“…In addition, carrying one or two doses of the L A allele for the 5-HTTLPR + rs25531 polymorphism in SLC6A4 was associated with a 47% decrease in the odds of belonging to the Higher Fatigue class. While rs2020942 was linked with obsessive-compulsive symptoms 123 and risk for nonsyndromic cleft lip with or without cleft palate, 124 no studies have reported on associations between SLC6A4 rs2020942 and energy level.…”

Section: Discussionmentioning

confidence: 99%

Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery

Eshragh

Dhruva

Paul

et al. 2017

Journal of Pain and Symptom Management

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Context Fatigue is a common problem in oncology patients. Less is known about decrements in energy levels and the mechanisms that underlie both fatigue and energy. Objectives In patients with breast cancer, variations in neurotransmitter genes between Lower and Higher Fatigue latent classes and between the Higher and Lower Energy latent classes were evaluated. Methods Patients completed assessments prior to and monthly for 6 months following surgery. Growth mixture modeling was used to identify distinct latent classes for fatigue severity and energy levels. Thirty candidate genes involved in various aspects of neurotransmission were evaluated. Results Eleven single nucleotide polymorphisms (SNPs) or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327 and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. Seven SNPs or haplotypes (i.e., NOS1 rs471871, SLC6A1 rs2675163, SLC6A1 Haplotype D01, SLC6A2 rs36027, SLC6A3 rs37022, SLC6A4 rs2020942, and TAC1 rs2072100) were associated with latent class membership for energy. Three of thirteen genes (i.e., NOS1, SLC6A2, SLC6A4) were associated with latent class membership for both fatigue and energy. Conclusions Molecular findings support the hypothesis that fatigue and energy are distinct, yet related symptoms. Results suggest that a large number of neurotransmitters play a role in the development and maintenance of fatigue and energy levels in breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery

Eshragh

Dhruva

Paul

et al. 2017

Journal of Pain and Symptom Management

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“…Another reason could be a gender difference in genetic modulation of depression by 5-HTTLPR. A gender-specific genetic effect has been reported for 5-HTTLPR in many psychiatric phenotypes, particularly in terms of the interaction with an environmental effect 28,29. It is possible that the genetic effect is moderated in a gender-specific way.…”

Section: Discussionmentioning

confidence: 99%

Genetic Role of BDNF Val66Met and 5-HTTLPR Polymorphisms on Depressive Disorder

Lee

Jeong

Kim

et al. 2014

Psychiatry Investig

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ObjectiveWe investigated possible association between depressive disorders and BDNF Val66Met and 5-HTTLPR. Brain derived neurotrophic factor (BDNF) gene and serotonin transporter (SLC6A4) gene are promising candidate genes for depressive disorders. It has been suggested that BDNF promotes the survival and differentiation of serotonergic neurons and that serotonergic transmission exerts powerful control over BDNF gene expression.MethodsFinal analyses were performed on 186 patients with depressive disorders and 1032 controls. Val66Met polymorphism of BDNF gene and 5-HTTLPR polymorphism of serotonin transporter gene were genotyped and allele and genotypic associations on the diagnosis of depression and age at onset of depression were analyzed.ResultsThe 5-HTTLPR was positively associated with depressive affected status in the total sample and in females (p=0.038 for allelewise, p=0.015 for genotype-wise associations), but, not in males. The BDNF Val66Met showed no association with depression. BDNF Val66Met and 5-HTTLPR alone were not associated with age at onset of depression. Additional analysis on the interaction between BDNF Val66Met and 5-HTTLPR found a significant association with age at onset of depression in the entire patient group. This association was also found in the female but not in the male patient group. None of the positive results survived Bonferroni correction for multiple testing.ConclusionThis result suggested that BDNF Val66Met and 5-HTTLPR may contribute to depressive disorders in a complex way and that the genetic effect could differ by gender. Further studies with large number of patients will be necessary.

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“…In genetic association studies, gender wise analysis has been recommended in several earlier reports [8][9][10]. In view of only two male patients in the cohort they were excluded to maintain uniformity of analysis.…”

Section: Subjectsmentioning

confidence: 99%

“…MBL2 gene is located at chromosome 10 (10q11. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] and comprises of four exons. Three functional SNPs in exon 1 at codons 52 (rs5030737; C > T; Arg > Cys), 54 (rs1800450; G > A; Gly > Asp), and 57 (rs1800451; G > A; Gly > Glu), are known as D, B, and C variants, respectively, whereas A is the common non-mutated allele.…”

Section: Introductionmentioning

confidence: 99%

Low producer MBL genotypes are associated with susceptibility to systemic lupus erythematosus in Odisha, India

Panda¹,

Parida²,

Tripathy³

et al. 2013

Human Immunology

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Sex determines which section of the SLC6A4 gene is linked to obsessive–compulsive symptoms in normal Chinese college students

Cited by 16 publications

References 78 publications

Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery

Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery

Genetic Role of BDNF Val66Met and 5-HTTLPR Polymorphisms on Depressive Disorder

Low producer MBL genotypes are associated with susceptibility to systemic lupus erythematosus in Odisha, India

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