Sex difference in age of onset of schizophrenia: findings from a community‐based study in India

Venkatesh, Basappa K.; Thirthalli, Jagadisha; Naveen, Magadi N.; Kishorekumar, Kengeri V.; Arunachala, Udupi; Venkatasubramanian, Ganesan; Subbakrishna, D. K.; Gangadhar, Bangalore N.

doi:10.1002/j.2051-5545.2008.tb00191.x

Cited by 44 publications

(31 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this gender difference was evident only among individuals, who became affected after the age of 25 years. The present results with a significant earlier mean onset among men only after a certain age is thus consistent with the Indian report [Venkatesh et al, 2008]. Given the association between the MTHFR 677T allele and elevated homocysteine concentrations, in this context it is of interest that several studies have reported elevated homocysteine blood levels among primarily young men diagnosed with schizophrenia [Levine et al, 2002; Applebaum et al, 2004; Adler Nevo et al, 2006].…”

Section: Discussionsupporting

confidence: 91%

“…The inability to replicate the European findings has been discussed in terms of different mortality rates among infants and less drug abuse, which may affect the genders differently. Interestingly, a recent community‐based rural Indian study reported an earlier age of onset in women than men before 30, whereas this relationship was reversed after the age of 30 [Venkatesh et al, 2008]. In our Scandinavian sample, onset of schizophrenia appeared approximately 1.5 years earlier in men than women.…”

Section: Discussionmentioning

confidence: 48%

See 1 more Smart Citation

Association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age of onset in schizophrenia

Vares

Saetre

Deng

et al. 2010

American J of Med Genetics Pt B

View full text Add to dashboard Cite

Different lines of evidence indicate that methylenetetrahydrofolate reductase (MTHFR) functional gene polymorphisms, causative in aberrant folate-homocysteine metabolism, are associated with increased vulnerability to several heritable developmental disorders. Opposing views are expressed considering the possible association between MTHFR and susceptibility for schizophrenia. In order to evaluate if age of onset could explain some of this discrepancy we investigated the relationship between two functional MTHFR gene polymorphisms and age at onset in this disorder. Scandinavian patients (n = 820) diagnosed with schizophrenia, schizoaffective disorder, and schizophreniform disorder were investigated. Two functional MTHFR single nucleotide polymorphisms (SNPs; rs1801131 and rs1801133) were genotyped and the effect of MTHFR polymorphisms on the age of onset was examined with survival analysis. In an attempt to replicate the findings from the Scandinavian sample, the association between rs1801133 and age at onset was also analyzed in Chinese high-risk families, with two or more affected siblings (n = 243). Among the Scandinavian patients the functional MTHFR SNP rs1801133 (C677T) significantly affected age at onset of schizophrenia in a dose-dependent manner (P = 0.0015), with lower age of onset with increasing numbers of the mutant T-allele. There was no evidence of rs1801131 (A1298C) affecting age of onset in schizophrenia. Within the Chinese high-risk families carriers of the MTHFR 677T allele showed earlier age at onset than siblings being homozygous for the wild-type allele (P = 0.008). The MTHFR C677T polymorphism may play a role as a modifying factor for age of onset in schizophrenia.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 48%

Association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age of onset in schizophrenia

Vares

Saetre

Deng

et al. 2010

American J of Med Genetics Pt B

View full text Add to dashboard Cite

show abstract

“…Four studies have addressed the situation of persons who suffer from schizophrenia and live in the community, and the effectiveness of community-level interventions. [32][33][34][35][36][37][38][39] These studies show the benefits of regular treatment in decreasing the patient's disability, the burden on the family and the costs incurred by the family. These studies also emphasize the need for community involvement in the care programmes.…”

Section: Limited Development Of the Dmhp In Its Operational Aspectsmentioning

confidence: 85%

“…The duration of illness at contact was more than 2 years in 90% of subjects and over 5 years in 70%, and in over 25% the duration was over 10 years. 31 This finding is important in view of the positive benefits of improvement in the clinical condition and decrease in the burden on the family, [32][33][34][35][36][37][38][39] and poorer clinical outcome with longer duration of illness. 38,39 'Psychological distress' requires medical intervention: Lack of awareness and stigma There are two aspects to the current lack of knowledge of the population about mental health.…”

Section: A Large 'Unmet Need' For Mental Healthcare In the Communitymentioning

confidence: 97%

Mental Health Initiatives in India (1947–2010)*

Murthy

2014

Social Work in Mental Health: Contexts and Theories for Practice

View full text Add to dashboard Cite

A network of decentralized mental health services for ameliorating the more common categories of disorders is envisaged. The programme outline for such a disease would involve the diagnosis of common disorders, and the prescription of common therapeutic drugs, by general duty medical staff. In regard to mental health institutions for indoor treatment of patients, the Policy envisages the upgrading of the physical infrastructure of such institutions at Central Government expense so as to secure the human rights of this vulnerable segment of society.' 1

show abstract

“…Several studies have reported gender difference in association with AAO in SCZ: for example, EGF gene [Lee et al, 2006] and PLA2G4A [Nadalin et al, 2008]. However, gender differences in AAO of SCZ are not consistent across all subgroups of schizophrenics [Leboyer et al, 1992b;Albus and Maier, 1995;Kendler and Walsh, 1995;Naqvi et al, 2005;Venkatesh et al, 2008].…”

Section: Neuropsychiatric Geneticsmentioning

confidence: 97%

Genome‐wide association analysis of age at onset in schizophrenia in a European‐American sample

Wang

Zhang³

et al. 2011

American J of Med Genetics Pt B

View full text Add to dashboard Cite

We performed a genome-wide association analysis to identify genetic variants influencing age at onset (AAO) and examine gene × gender interactions for AAO in schizophrenia (SCZ) using a European-American sample (1,162 cases). Linear regression model in PLINK was used to test for associations with AAO while the GxE option was chosen to test for the influence of gene × gender interactions. The most significant association with AAO was observed with SNP rs7819815 (P = 3.10×10(-7)) at 8q24.22. The next best signal was at 4q25 in COL25A1 gene (rs17039583, P = 4.30×10(-6)) and the third region was at 4p16.1 (rs17407555, P = 4.56×10(-6) , near RAF1P1, and rs4697924, P = 1.23×10(-5) within WDR1 gene). Conditional analysis on chromosome 4 indicated that 4p16.1 and 4q25 loci were independent. Furthermore, 2 SNPs (rs16834822 and rs16834824) at 1q43 in RYR2 showed strong associations in the female sample (P = 2.10×10(-6) and 2.33×10(-6) , respectively) and strong gene × gender interactions in influencing AAO (P = 9.23×10(-7) and 1.15×10(-6) , respectively) while the second best region showing gene × gender interaction was at 7q22.3 (rs179863, P = 2.33×10(-6) ). Using an independent sample of 1,068 cases, we could not replicate the associations for above top SNPs; however, we found nominal significance associations for their flanking SNPs (P < 0.05). These findings provide evidence of several genetic variants influencing AAO of SCZ.

show abstract

Sex difference in age of onset of schizophrenia: findings from a community‐based study in India

Cited by 44 publications

References 14 publications

Association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age of onset in schizophrenia

Association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age of onset in schizophrenia

Mental Health Initiatives in India (1947–2010)*

Genome‐wide association analysis of age at onset in schizophrenia in a European‐American sample

Contact Info

Product

Resources

About